GNRH2 (gonadotropin releasing hormone 2)

2007-02-01  

Identity

HGNC
LOCATION
20p13
LOCUSID
ALIAS
GnRH-II,LH-RHII

Other Information

Locus ID:

NCBI: 2797
MIM: 602352
HGNC: 4420
Ensembl: ENSG00000125787

Variants:

dbSNP: 2797
ClinVar: 2797
TCGA: ENSG00000125787
COSMIC: GNRH2

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000125787ENST00000245983O43555
ENSG00000125787ENST00000359100O43555
ENSG00000125787ENST00000380346O43555
ENSG00000125787ENST00000380347O43555

Expression (GTEx)

0
1
2
3
4

Pathways

PathwaySourceExternal ID
GnRH signaling pathwayKEGGko04912
GnRH signaling pathwayKEGGhsa04912
Signal TransductionREACTOMER-HSA-162582
Signaling by GPCRREACTOMER-HSA-372790
GPCR ligand bindingREACTOMER-HSA-500792
Class A/1 (Rhodopsin-like receptors)REACTOMER-HSA-373076
Hormone ligand-binding receptorsREACTOMER-HSA-375281
GPCR downstream signalingREACTOMER-HSA-388396
G alpha (q) signalling eventsREACTOMER-HSA-416476
Gastrin-CREB signalling pathway via PKC and MAPKREACTOMER-HSA-881907

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
203796142010Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.62
190860532009Identification of new putative susceptibility genes for several psychiatric disorders by association analysis of regulatory and non-synonymous SNPs of 306 genes involved in neurotransmission and neurodevelopment.34
124473562002The neuropeptides GnRH-II and GnRH-I are produced by human T cells and trigger laminin receptor gene expression, adhesion, chemotaxis and homing to specific organs.23
147262582003The biology of gonadotropin hormone-releasing hormone: role in the control of tumor growth and progression in humans.22
194532612009High-density association study of 383 candidate genes for volumetric BMD at the femoral neck and lumbar spine among older men.20
127707442003Multi-factorial role of GnRH-I and GnRH-II in the human ovary.12
150016482004Cellular localization of gonadotropin-releasing hormone (GnRH) I and GnRH II in first-trimester human placenta and decidua.10
184675262008Gonadotropin-releasing hormone analog structural determinants of selectivity for inhibition of cell growth: support for the concept of ligand-induced selective signaling.9
21193558201137-kDa laminin receptor precursor mediates GnRH-II-induced MMP-2 expression and invasiveness in ovarian cancer cells.9
129695782003Possible interactions between leptin, gonadotrophin-releasing hormone (GnRH-I and II) and human chorionic gonadotrophin (hCG).8

Citation

Dessen P

GNRH2 (gonadotropin releasing hormone 2)

Atlas Genet Cytogenet Oncol Haematol. 2007-02-01

Online version: http://atlasgeneticsoncology.org/gene/45598/gnrh2