Atlas of Genetics and Cytogenetics in Oncology and Haematology


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GNS (glucosamine (N-acetyl)-6-sulfatase)

Identity

Other namesG6S
HGNC (Hugo) GNS
LocusID (NCBI) 2799
Location 12q14.3
Location_base_pair Starts at 65107222 and ends at 65153226 bp from pter ( according to hg19-Feb_2009)
Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 

External links

Nomenclature
HGNC (Hugo)GNS   4422
Cards
Entrez_Gene (NCBI)GNS  2799  glucosamine (N-acetyl)-6-sulfatase
GeneCards (Weizmann)GNS
Ensembl hg19 (Hinxton)ENSG00000135677 [Gene_View]  chr12:65107222-65153226 [Contig_View]  GNS [Vega]
Ensembl hg38 (Hinxton)ENSG00000135677 [Gene_View]  chr12:65107222-65153226 [Contig_View]  GNS [Vega]
ICGC DataPortalENSG00000135677
cBioPortalGNS
AceView (NCBI)GNS
Genatlas (Paris)GNS
WikiGenes2799
SOURCE (Princeton)GNS
Genomic and cartography
GoldenPath hg19 (UCSC)GNS  -     chr12:65107222-65153226 -  12q14.3   [Description]    (hg19-Feb_2009)
GoldenPath hg38 (UCSC)GNS  -     12q14.3   [Description]    (hg38-Dec_2013)
EnsemblGNS - 12q14.3 [CytoView hg19]  GNS - 12q14.3 [CytoView hg38]
Mapping of homologs : NCBIGNS [Mapview hg19]  GNS [Mapview hg38]
OMIM252940   607664   
Gene and transcription
Genbank (Entrez)AA725727 AK054660 AK223484 AK291771 AK296759
RefSeq transcript (Entrez)NM_002076
RefSeq genomic (Entrez)AC_000144 NC_000012 NC_018923 NG_008955 NT_029419 NW_001838060 NW_004929384
Consensus coding sequences : CCDS (NCBI)GNS
Cluster EST : UnigeneHs.334534 [ NCBI ]
CGAP (NCI)Hs.334534
Alternative Splicing : Fast-db (Paris)GSHG0007599
Alternative Splicing GalleryENSG00000135677
Gene ExpressionGNS [ NCBI-GEO ]     GNS [ SEEK ]   GNS [ MEM ]
SOURCE (Princeton)Expression in : [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
Protein : pattern, domain, 3D structure
UniProt/SwissProtP15586 (Uniprot)
NextProtP15586  [Medical]
With graphics : InterProP15586
Splice isoforms : SwissVarP15586 (Swissvar)
Catalytic activity : Enzyme3.1.6.14 [ Enzyme-Expasy ]   3.1.6.143.1.6.14 [ IntEnz-EBI ]   3.1.6.14 [ BRENDA ]   3.1.6.14 [ KEGG ]   
Domaine pattern : Prosite (Expaxy)SULFATASE_1 (PS00523)    SULFATASE_2 (PS00149)   
Domains : Interpro (EBI)Alkaline_Pase-like_a/b/a    Alkaline_phosphatase_core    GlcNAc_6-SO4ase    GlcNAc_6-SO4ase_euk    Sulfatase    Sulfatase_CS   
Related proteins : CluSTrP15586
Domain families : Pfam (Sanger)Sulfatase (PF00884)   
Domain families : Pfam (NCBI)pfam00884   
DMDM Disease mutations2799
Blocks (Seattle)P15586
Human Protein AtlasENSG00000135677
Peptide AtlasP15586
HPRD09637
IPIIPI00012102   IPI00909554   IPI00908404   IPI00979679   IPI01011079   IPI01010523   IPI01010051   IPI01015586   
Protein Interaction databases
DIP (DOE-UCLA)P15586
IntAct (EBI)P15586
FunCoupENSG00000135677
BioGRIDGNS
IntegromeDBGNS
STRING (EMBL)GNS
Ontologies - Pathways
QuickGOP15586
Ontology : AmiGOprotein binding  carbohydrate metabolic process  glycosaminoglycan catabolic process  N-acetylglucosamine-6-sulfatase activity  sulfuric ester hydrolase activity  glycosaminoglycan metabolic process  keratan sulfate metabolic process  keratan sulfate catabolic process  lysosomal lumen  small molecule metabolic process  metal ion binding  extracellular vesicular exosome  
Ontology : EGO-EBIprotein binding  carbohydrate metabolic process  glycosaminoglycan catabolic process  N-acetylglucosamine-6-sulfatase activity  sulfuric ester hydrolase activity  glycosaminoglycan metabolic process  keratan sulfate metabolic process  keratan sulfate catabolic process  lysosomal lumen  small molecule metabolic process  metal ion binding  extracellular vesicular exosome  
Pathways : KEGGGlycosaminoglycan degradation    Lysosome   
Protein Interaction DatabaseGNS
DoCM (Curated mutations)GNS
Wikipedia pathwaysGNS
Gene fusion - rearrangements
Polymorphisms : SNP, variants
NCBI Variation ViewerGNS [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)GNS
dbVarGNS
ClinVarGNS
1000_GenomesGNS 
Exome Variant ServerGNS
SNP (GeneSNP Utah)GNS
SNP : HGBaseGNS
Genetic variants : HAPMAPGNS
Genomic VariantsGNS  GNS [DGVbeta]
Mutations
ICGC Data PortalENSG00000135677 
Somatic Mutations in Cancer : COSMICGNS 
CONAN: Copy Number AnalysisGNS 
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] 
Diseases
DECIPHER (Syndromes)12:65107222-65153226
Mutations and Diseases : HGMDGNS
OMIM252940    607664   
MedgenGNS
NextProtP15586 [Medical]
GENETestsGNS
Disease Genetic AssociationGNS
Huge Navigator GNS [HugePedia]  GNS [HugeCancerGEM]
snp3D : Map Gene to Disease2799
DGIdb (Drug Gene Interaction db)GNS
General knowledge
Homologs : HomoloGeneGNS
Homology/Alignments : Family Browser (UCSC)GNS
Phylogenetic Trees/Animal Genes : TreeFamGNS
Chemical/Protein Interactions : CTD2799
Chemical/Pharm GKB GenePA28802
Clinical trialGNS
Cancer Resource (Charite)ENSG00000135677
Other databases
Probes
Litterature
PubMed25 Pubmed reference(s) in Entrez
CoreMineGNS
GoPubMedGNS
iHOPGNS
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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Contributor(s)

Written09-2002Dessen P, Le Minor S
Updated12-2014Dessen P

© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Sat Dec 20 21:49:02 CET 2014

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