GORASP1 (golgi reassembly stacking protein 1)

2016-12-01  

Identity

HGNC
GORASP1
LOCATION
3p22.2
LOCUSID
64689
ALIAS
GOLPH5,GRASP65,P65
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 64689
MIM: 606867
HGNC: 16769
Ensembl: ENSG00000114745

Variants:

dbSNP: 64689
ClinVar: 64689
TCGA: ENSG00000114745
COSMIC: GORASP1

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000114745ENST00000319283Q9BQQ3
ENSG00000114745ENST00000319283A0A024R2U5
ENSG00000114745ENST00000416741C9J5S6
ENSG00000114745ENST00000419156H7C0J2
ENSG00000114745ENST00000422110B3KPY8
ENSG00000114745ENST00000431601Q9BQQ3
ENSG00000114745ENST00000437458C9J0V5
ENSG00000114745ENST00000441081C9J9V9
ENSG00000114745ENST00000452389Q9BQQ3
ENSG00000114745ENST00000453680G3V0G1
ENSG00000114745ENST00000479927B4E1H8

Expression (GTEx)

0
5
10
15
20
25
30
35
40
45
50
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Metabolism of proteinsREACTOMER-HSA-392499
Post-translational protein modificationREACTOMER-HSA-597592
Asparagine N-linked glycosylationREACTOMER-HSA-446203
Transport to the Golgi and subsequent modificationREACTOMER-HSA-948021
ER to Golgi Anterograde TransportREACTOMER-HSA-199977
COPII (Coat Protein 2) Mediated Vesicle TransportREACTOMER-HSA-204005
Cell CycleREACTOMER-HSA-1640170
Cell Cycle, MitoticREACTOMER-HSA-69278
M PhaseREACTOMER-HSA-68886
Mitotic ProphaseREACTOMER-HSA-68875
Golgi Cisternae Pericentriolar Stack ReorganizationREACTOMER-HSA-162658
Vesicle-mediated transportREACTOMER-HSA-5653656
Membrane TraffickingREACTOMER-HSA-199991
COPI-mediated anterograde transportREACTOMER-HSA-6807878

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
93462421997GRASP65, a protein involved in the stacking of Golgi cisternae.152
164893442006GM130 and GRASP65-dependent lateral cisternal fusion allows uniform Golgi-enzyme distribution.151
199131212009Gene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip.85
96288631998Mapping the interaction between GRASP65 and GM130, components of a protein complex involved in the stacking of Golgi cisternae.84
200836032010GRASP55 and GRASP65 play complementary and essential roles in Golgi cisternal stacking.72
155763682005Mapping the functional domains of the Golgi stacking factor GRASP65.70
158885442005The Golgi-associated protein GRASP65 regulates spindle dynamics and is essential for cell division.67
235520742013Regulation of protein glycosylation and sorting by the Golgi matrix proteins GRASP55/65.56
195814112009Organelle tethering by a homotypic PDZ interaction underlies formation of the Golgi membrane network.41
158341322005Convergence of cell cycle regulation and growth factor signals on GRASP65.39

Citation

Dessen P

GORASP1 (golgi reassembly stacking protein 1)

Atlas Genet Cytogenet Oncol Haematol. 2016-12-01

Online version: http://atlasgeneticsoncology.org/gene/56688/gorasp1