Atlas of Genetics and Cytogenetics in Oncology and Haematology


Home   Genes   Leukemias   Solid Tumors   Cancer-Prone   Deep Insight   Case Reports   Journals  Portal   Teaching   

X Y 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 NA

GOT2 (glutamic-oxaloacetic transaminase 2)

Identity

Alias_namesglutamic-oxaloacetic transaminase 2, mitochondrial (aspartate aminotransferase 2)
glutamic-oxaloacetic transaminase 2, mitochondrial
Alias_symbol (synonym)mitAAT
KATIV
KAT4
KYAT4
Other alias
HGNC (Hugo) GOT2
LocusID (NCBI) 2806
Atlas_Id 55965
Location 16q21  [Link to chromosome band 16q21]
Location_base_pair Starts at 58707131 and ends at 58734357 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2016)
EML2 (19q13.32) / GOT2 (16q21)GOT2 (16q21) / HTT (4p16.3)MIR548N (2q31.2) / GOT2 (16q21)
SLC38A7 (16q21) / GOT2 (16q21)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)GOT2   4433
Cards
Entrez_Gene (NCBI)GOT2  2806  glutamic-oxaloacetic transaminase 2
AliasesKAT4; KATIV; KYAT4; mitAAT
GeneCards (Weizmann)GOT2
Ensembl hg19 (Hinxton)ENSG00000125166 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000125166 [Gene_View]  chr16:58707131-58734357 [Contig_View]  GOT2 [Vega]
ICGC DataPortalENSG00000125166
TCGA cBioPortalGOT2
AceView (NCBI)GOT2
Genatlas (Paris)GOT2
WikiGenes2806
SOURCE (Princeton)GOT2
Genetics Home Reference (NIH)GOT2
Genomic and cartography
GoldenPath hg38 (UCSC)GOT2  -     chr16:58707131-58734357 -  16q21   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)GOT2  -     16q21   [Description]    (hg19-Feb_2009)
EnsemblGOT2 - 16q21 [CytoView hg19]  GOT2 - 16q21 [CytoView hg38]
Mapping of homologs : NCBIGOT2 [Mapview hg19]  GOT2 [Mapview hg38]
OMIM138150   
Gene and transcription
Genbank (Entrez)AK098313 AK223271 AK290847 AK295993 AK302249
RefSeq transcript (Entrez)NM_001286220 NM_002080
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)GOT2
Cluster EST : UnigeneHs.599470 [ NCBI ]
CGAP (NCI)Hs.599470
Alternative Splicing GalleryENSG00000125166
Gene ExpressionGOT2 [ NCBI-GEO ]   GOT2 [ EBI - ARRAY_EXPRESS ]   GOT2 [ SEEK ]   GOT2 [ MEM ]
Gene Expression Viewer (FireBrowse)GOT2 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)2806
GTEX Portal (Tissue expression)GOT2
Protein : pattern, domain, 3D structure
UniProt/SwissProtP00505   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtP00505  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProP00505
Splice isoforms : SwissVarP00505
Catalytic activity : Enzyme2.6.1.1 [ Enzyme-Expasy ]   2.6.1.12.6.1.1 [ IntEnz-EBI ]   2.6.1.1 [ BRENDA ]   2.6.1.1 [ KEGG ]   
PhosPhoSitePlusP00505
Domaine pattern : Prosite (Expaxy)AA_TRANSFER_CLASS_1 (PS00105)   
Domains : Interpro (EBI)Aminotransferase_I/II    Asp_trans    NHTrfase_class1_PyrdxlP-BS    PyrdxlP-dep_Trfase    PyrdxlP-dep_Trfase_major_sub1   
Domain families : Pfam (Sanger)Aminotran_1_2 (PF00155)   
Domain families : Pfam (NCBI)pfam00155   
Conserved Domain (NCBI)GOT2
DMDM Disease mutations2806
Blocks (Seattle)GOT2
PDB (SRS)5AX8   
PDB (PDBSum)5AX8   
PDB (IMB)5AX8   
PDB (RSDB)5AX8   
Structural Biology KnowledgeBase5AX8   
SCOP (Structural Classification of Proteins)5AX8   
CATH (Classification of proteins structures)5AX8   
SuperfamilyP00505
Human Protein AtlasENSG00000125166
Peptide AtlasP00505
HPRD00684
IPIIPI00018206   IPI00910267   IPI00908623   
Protein Interaction databases
DIP (DOE-UCLA)P00505
IntAct (EBI)P00505
FunCoupENSG00000125166
BioGRIDGOT2
STRING (EMBL)GOT2
ZODIACGOT2
Ontologies - Pathways
QuickGOP00505
Ontology : AmiGORNA binding  L-aspartate:2-oxoglutarate aminotransferase activity  L-aspartate:2-oxoglutarate aminotransferase activity  L-aspartate:2-oxoglutarate aminotransferase activity  phospholipid binding  mitochondrion  mitochondrion  mitochondrial inner membrane  mitochondrial matrix  plasma membrane  gluconeogenesis  2-oxoglutarate metabolic process  oxaloacetate metabolic process  aspartate metabolic process  aspartate biosynthetic process  aspartate catabolic process  glutamate metabolic process  cellular amino acid biosynthetic process  cell surface  fatty acid transport  kynurenine-oxoglutarate transaminase activity  amino acid binding  4-hydroxyproline catabolic process  glutamate catabolic process to aspartate  glutamate catabolic process to 2-oxoglutarate  enzyme binding  pyridoxal phosphate binding  protein homodimerization activity  perikaryon  myelin sheath  protein complex  response to ethanol  extracellular exosome  L-phenylalanine:2-oxoglutarate aminotransferase activity  L-kynurenine metabolic process  
Ontology : EGO-EBIRNA binding  L-aspartate:2-oxoglutarate aminotransferase activity  L-aspartate:2-oxoglutarate aminotransferase activity  L-aspartate:2-oxoglutarate aminotransferase activity  phospholipid binding  mitochondrion  mitochondrion  mitochondrial inner membrane  mitochondrial matrix  plasma membrane  gluconeogenesis  2-oxoglutarate metabolic process  oxaloacetate metabolic process  aspartate metabolic process  aspartate biosynthetic process  aspartate catabolic process  glutamate metabolic process  cellular amino acid biosynthetic process  cell surface  fatty acid transport  kynurenine-oxoglutarate transaminase activity  amino acid binding  4-hydroxyproline catabolic process  glutamate catabolic process to aspartate  glutamate catabolic process to 2-oxoglutarate  enzyme binding  pyridoxal phosphate binding  protein homodimerization activity  perikaryon  myelin sheath  protein complex  response to ethanol  extracellular exosome  L-phenylalanine:2-oxoglutarate aminotransferase activity  L-kynurenine metabolic process  
Pathways : KEGG   
NDEx NetworkGOT2
Atlas of Cancer Signalling NetworkGOT2
Wikipedia pathwaysGOT2
Orthology - Evolution
OrthoDB2806
GeneTree (enSembl)ENSG00000125166
Phylogenetic Trees/Animal Genes : TreeFamGOT2
HOVERGENP00505
HOGENOMP00505
Homologs : HomoloGeneGOT2
Homology/Alignments : Family Browser (UCSC)GOT2
Gene fusions - Rearrangements
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerGOT2 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)GOT2
dbVarGOT2
ClinVarGOT2
1000_GenomesGOT2 
Exome Variant ServerGOT2
ExAC (Exome Aggregation Consortium)GOT2 (select the gene name)
Genetic variants : HAPMAP2806
Genomic Variants (DGV)GOT2 [DGVbeta]
DECIPHERGOT2 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisGOT2 
Mutations
ICGC Data PortalGOT2 
TCGA Data PortalGOT2 
Broad Tumor PortalGOT2
OASIS PortalGOT2 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICGOT2  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDGOT2
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
LOVD (Leiden Open Variation Database)MSeqDR-LSDB Mitochondrial Disease Locus Specific Database
BioMutasearch GOT2
DgiDB (Drug Gene Interaction Database)GOT2
DoCM (Curated mutations)GOT2 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)GOT2 (select a term)
intoGenGOT2
Cancer3DGOT2(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM138150   
Orphanet
MedgenGOT2
Genetic Testing Registry GOT2
NextProtP00505 [Medical]
TSGene2806
GENETestsGOT2
Target ValidationGOT2
Huge Navigator GOT2 [HugePedia]
snp3D : Map Gene to Disease2806
BioCentury BCIQGOT2
ClinGenGOT2
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD2806
Chemical/Pharm GKB GenePA28818
Clinical trialGOT2
Miscellaneous
canSAR (ICR)GOT2 (select the gene name)
Probes
Litterature
PubMed54 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineGOT2
EVEXGOT2
GoPubMedGOT2
iHOPGOT2
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

Search in all EBI   NCBI

© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Mon Sep 18 13:54:34 CEST 2017

Home   Genes   Leukemias   Solid Tumors   Cancer-Prone   Deep Insight   Case Reports   Journals  Portal   Teaching   

For comments and suggestions or contributions, please contact us

jlhuret@AtlasGeneticsOncology.org.