GP1BA (glycoprotein Ib platelet subunit alpha)

2007-02-01  

Identity

HGNC
LOCATION
17p13.2
LOCUSID
ALIAS
BDPLT1,BDPLT3,BSS,CD42B,CD42b-alpha,DBPLT3,GP1B,GPIbA,GPIbalpha,VWDP

Other Information

Locus ID:

NCBI: 2811
MIM: 606672
HGNC: 4439
Ensembl: ENSG00000185245

Variants:

dbSNP: 2811
ClinVar: 2811
TCGA: ENSG00000185245
COSMIC: GP1BA

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000185245ENST00000329125P07359
ENSG00000185245ENST00000611961A0A0C4DGZ8

Expression (GTEx)

0
1
2
3
4
5

Pathways

PathwaySourceExternal ID
ECM-receptor interactionKEGGko04512
Hematopoietic cell lineageKEGGko04640
ECM-receptor interactionKEGGhsa04512
Hematopoietic cell lineageKEGGhsa04640
Platelet activationKEGGhsa04611
HemostasisREACTOMER-HSA-109582
Platelet Adhesion to exposed collagenREACTOMER-HSA-75892
Platelet activation, signaling and aggregationREACTOMER-HSA-76002
GP1b-IX-V activation signallingREACTOMER-HSA-430116
Platelet Aggregation (Plug Formation)REACTOMER-HSA-76009
Formation of Fibrin Clot (Clotting Cascade)REACTOMER-HSA-140877
Intrinsic Pathway of Fibrin Clot FormationREACTOMER-HSA-140837

Protein levels (Protein atlas)

Not detected
Low
Medium
High

PharmGKB

Entity IDNameTypeEvidenceAssociationPKPDPMIDs
PA448497aspirinChemicalClinicalAnnotationassociatedPD17245331, 18417193

References

Pubmed IDYearTitleCitations
187259992008Platelet glycoprotein Ibalpha forms catch bonds with human WT vWF but not with type 2B von Willebrand disease vWF.129
199131212009Gene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip.85
207250432010A mechanically stabilized receptor-ligand flex-bond important in the vasculature.85
155017842004The Streptococcus gordonii surface proteins GspB and Hsa mediate binding to sialylated carbohydrate epitopes on the platelet membrane glycoprotein Ibalpha.68
162606372005Leukocyte engagement of platelet glycoprotein Ibalpha via the integrin Mac-1 is critical for the biological response to vascular injury.62
174947582007Platelet glycoprotein Ib alpha supports experimental lung metastasis.55
128558102003Modulation of alpha-thrombin function by distinct interactions with platelet glycoprotein Ibalpha.45
163733312006Shielding of the A1 domain by the D'D3 domains of von Willebrand factor modulates its interaction with platelet glycoprotein Ib-IX-V.44
174142172007Signaling and regulation of the platelet glycoprotein Ib-IX-V complex.41
120368792002Endothelial von Willebrand factor recruits platelets to atherosclerosis-prone sites in response to hypercholesterolemia.39

Citation

Dessen P

GP1BA (glycoprotein Ib platelet subunit alpha)

Atlas Genet Cytogenet Oncol Haematol. 2007-02-01

Online version: http://atlasgeneticsoncology.org/gene/46312/gp1ba