GP5 (glycoprotein V platelet)

2014-11-01 Affiliation

Identity

HGNC

GP5

LOCATION

3q29

LOCUSID

2814

ALIAS

CD42d,GPV

Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool

Other Information

Locus ID:

NCBI: 2814
MIM: 173511
HGNC: 4443
Ensembl: ENSG00000178732

Variants:

dbSNP: 2814
ClinVar: 2814
TCGA: ENSG00000178732
COSMIC: GP5

RNA/Proteins

Gene ID	Transcript ID	Uniprot
ENSG00000178732	ENST00000401815	P40197

Expression (GTEx)

Adipose - Subcutaneous

Adipose - Visceral

Adrenal Gland

Artery - Aorta

Artery - Tibial

Bladder

Brain - Amygdala

Brain - Anterior cingulate cortex

Brain - Caudate

Brain - Cerebellar Hemisphere

Brain - Cerebellum

Brain - Cortex

Brain - Frontal Cortex

Brain - Hippocampus

Brain - Hypothalamus

Brain - Nucleus accumbens

Brain - Putamen

Brain - Spinal cord

Brain - Substantia nigra

Breast - Mammary Tissue

Cells - Cultured fibroblasts

Cells - EBV - transformed lymphocytes

Cervix - Ectocervix

Cervix - Endocervix

Colon - Sigmoid

Colon - Transverse

Esophagus - Gastroesophageal Junction

Esophagus - Mucosa

Esophagus - Muscularis

Fallopian Tube

Heart - Atrial Appendage

Heart - Left Ventricle

Kidney - Cortex

Kidney - Medulla

Liver

Lung

Minor Salivary Gland

Muscle - Skeletal

Nerve - Tibial

Ovary

Pancreas

Pituitary

Prostate

Skin - Not Sun Exposed

Skin - Sun Exposed

Small Intestine - Terminal Ileum

Spleen

Stomach

Testis

Thyroid

Uterus

Vagina

Whole Blood

Pathways

Pathway	Source	External ID
ECM-receptor interaction	KEGG	ko04512
Hematopoietic cell lineage	KEGG	ko04640
ECM-receptor interaction	KEGG	hsa04512
Hematopoietic cell lineage	KEGG	hsa04640
Platelet activation	KEGG	hsa04611
Hemostasis	REACTOME	R-HSA-109582
Platelet Adhesion to exposed collagen	REACTOME	R-HSA-75892
Platelet activation, signaling and aggregation	REACTOME	R-HSA-76002
GP1b-IX-V activation signalling	REACTOME	R-HSA-430116
Platelet Aggregation (Plug Formation)	REACTOME	R-HSA-76009
Formation of Fibrin Clot (Clotting Cascade)	REACTOME	R-HSA-140877
Intrinsic Pathway of Fibrin Clot Formation	REACTOME	R-HSA-140837

PharmGKB

Entity ID	Name	Type	Evidence	Association	PMIDs
PA26716	COL3A1	Gene	Pathway	associated	20938371
PA26717	COL4A1	Gene	Pathway	associated	20938371
PA26718	COL4A2	Gene	Pathway	associated	20938371
PA33384	PLCB1	Gene	Pathway	associated	20938371
PA33393	PLCG2	Gene	Pathway	associated	20938371
PA35041	COL1A1	Gene	Pathway	associated	20938371
PA35042	COL1A2	Gene	Pathway	associated	20938371

References

Pubmed ID	Year	Title	Citations
19913121	2009	Gene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip.	85
20379614	2010	Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.	62
15691827	2005	Evidence for a role of ADAM17 (TACE) in the regulation of platelet glycoprotein V.	30
18612104	2008	The glycoprotein Ib-IX-V complex contributes to tissue factor-independent thrombin generation by recombinant factor VIIa on the activated platelet surface.	14
18450753	2008	Redundant mechanism of platelet adhesion to laminin and collagen under flow: involvement of von Willebrand factor and glycoprotein Ib-IX-V.	13
15477207	2004	Application of a diagnostic algorithm for inherited thrombocytopenias to 46 consecutive patients.	11
20628086	2010	Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study.	11
21529934	2011	Delineating the roles of the GPIIb/IIIa and GP-Ib-IX-V platelet receptors in mediating platelet adhesion to adsorbed fibrinogen and albumin.	10
16179345	2005	Aspirin induces platelet receptor shedding via ADAM17 (TACE).	8
19874464	2010	The platelet glycoprotein Ib-IX-V complex anchors lipid rafts to the membrane skeleton: implications for activation-dependent cytoskeletal translocation of signaling molecules.	8

Citation

Dessen P

GP5 (glycoprotein V platelet)

Atlas Genet Cytogenet Oncol Haematol. 2014-11-01

Online version: http://atlasgeneticsoncology.org/gene/63917/gp5