GPAM (glycerol-3-phosphate acyltransferase, mitochondrial)

2012-08-01 Affiliation

Identity

HGNC

GPAM

LOCATION

10q25.2

LOCUSID

57678

ALIAS

GPAT,GPAT1

FUSION GENES

Show Gene Fusions

Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool

Other Information

Locus ID:

NCBI: 57678
MIM: 602395
HGNC: 24865
Ensembl: ENSG00000119927

Variants:

dbSNP: 57678
ClinVar: 57678
TCGA: ENSG00000119927
COSMIC: GPAM

RNA/Proteins

Gene ID	Transcript ID	Uniprot
ENSG00000119927	ENST00000348367	Q9HCL2
ENSG00000119927	ENST00000369425	Q5VW52

Expression (GTEx)

Adipose - Subcutaneous

Adipose - Visceral

Adrenal Gland

Artery - Aorta

Artery - Tibial

Bladder

Brain - Amygdala

Brain - Anterior cingulate cortex

Brain - Caudate

Brain - Cerebellar Hemisphere

Brain - Cerebellum

Brain - Cortex

Brain - Frontal Cortex

Brain - Hippocampus

Brain - Hypothalamus

Brain - Nucleus accumbens

Brain - Putamen

Brain - Spinal cord

Brain - Substantia nigra

Breast - Mammary Tissue

Cells - Cultured fibroblasts

Cells - EBV - transformed lymphocytes

Cervix - Ectocervix

Cervix - Endocervix

Colon - Sigmoid

Colon - Transverse

Esophagus - Gastroesophageal Junction

Esophagus - Mucosa

Esophagus - Muscularis

Fallopian Tube

Heart - Atrial Appendage

Heart - Left Ventricle

Kidney - Cortex

Kidney - Medulla

Liver

Lung

Minor Salivary Gland

Muscle - Skeletal

Nerve - Tibial

Ovary

Pancreas

Pituitary

Prostate

Skin - Not Sun Exposed

Skin - Sun Exposed

Small Intestine - Terminal Ileum

Spleen

Stomach

Testis

Thyroid

Uterus

Vagina

Whole Blood

Pathways

Pathway	Source	External ID
Glycerolipid metabolism	KEGG	ko00561
Glycerophospholipid metabolism	KEGG	ko00564
Glycerolipid metabolism	KEGG	hsa00561
Glycerophospholipid metabolism	KEGG	hsa00564
Metabolic pathways	KEGG	hsa01100
Triacylglycerol biosynthesis	KEGG	hsa_M00089
Triacylglycerol biosynthesis	KEGG	M00089
Metabolism	REACTOME	R-HSA-1430728
Metabolism of lipids and lipoproteins	REACTOME	R-HSA-556833
Fatty acid, triacylglycerol, and ketone body metabolism	REACTOME	R-HSA-535734
Triglyceride Biosynthesis	REACTOME	R-HSA-75109
Regulation of cholesterol biosynthesis by SREBP (SREBF)	REACTOME	R-HSA-1655829
Activation of gene expression by SREBF (SREBP)	REACTOME	R-HSA-2426168
Phospholipid metabolism	REACTOME	R-HSA-1483257
Glycerophospholipid biosynthesis	REACTOME	R-HSA-1483206
Synthesis of PA	REACTOME	R-HSA-1483166

Protein levels (Protein atlas)

Not detected

Low

Medium

High

PharmGKB

Entity ID	Name	Type	Evidence	Association	PMIDs
PA33744	PRKAA1	Gene	Pathway	associated	22722338
PA33745	PRKAA2	Gene	Pathway	associated	22722338
PA33746	PRKAB1	Gene	Pathway	associated	22722338
PA33747	PRKAB2	Gene	Pathway	associated	22722338
PA33751	PRKAG1	Gene	Pathway	associated	22722338
PA33752	PRKAG2	Gene	Pathway	associated	22722338
PA33753	PRKAG3	Gene	Pathway	associated	22722338

References

Pubmed ID	Year	Title	Citations
16385451	2006	A scan of chromosome 10 identifies a novel locus showing strong association with late-onset Alzheimer disease.	69
18660489	2008	Multiple genetic variants along candidate pathways influence plasma high-density lipoprotein cholesterol concentrations.	26
22070544	2012	Integration of metabolomics and expression of glycerol-3-phosphate acyltransferase (GPAM) in breast cancer-link to patient survival, hormone receptor status, and metabolic profiling.	24
20453000	2010	A Large-scale genetic association study of esophageal adenocarcinoma risk.	23
20877624	2010	Genetic variants in nuclear-encoded mitochondrial genes influence AIDS progression.	17
28652252	2017	Glycerol-3-phosphate Acyltransferase 1 Promotes Tumor Cell Migration and Poor Survival in Ovarian Carcinoma.	14
22634312	2012	Identification and functional characterization of human glycerol-3-phosphate acyltransferase 1 gene promoters.	6
19209188	2009	Genetic association analysis of 13 nuclear-encoded mitochondrial candidate genes with type II diabetes mellitus: the DAMAGE study.	4

Citation

Dessen P

GPAM (glycerol-3-phosphate acyltransferase, mitochondrial)

Atlas Genet Cytogenet Oncol Haematol. 2012-08-01

Online version: http://atlasgeneticsoncology.org/gene/52786/gpam