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GPAT4 (glycerol-3-phosphate acyltransferase 4)

Identity

Alias_namesAGPAT6
1-acylglycerol-3-phosphate O-acyltransferase 6 (lysophosphatidic acid acyltransferase, zeta)
1-acylglycerol-3-phosphate O-acyltransferase 6
Alias_symbol (synonym)DKFZp586M1819
LPAAT-zeta
TSARG7
Other alias1-AGPAT 6
LPAATZ
HGNC (Hugo) GPAT4
LocusID (NCBI) 137964
Atlas_Id 77796
Location 8p11.21  [Link to chromosome band 8p11]
Location_base_pair Starts at 41578188 and ends at 41625001 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
CDK2AP2 (11q13.2) / GPAT4 (8p11.21)GPAT4 (8p11.21) / ADAM9 (8p11.22)HGSNAT (8p11.21) / GPAT4 (8p11.21)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)GPAT4   20880
Cards
Entrez_Gene (NCBI)GPAT4  137964  glycerol-3-phosphate acyltransferase 4
Aliases1-AGPAT; AGPAT6; LPAAT-zeta; LPAATZ; 
TSARG7
GeneCards (Weizmann)GPAT4
Ensembl hg19 (Hinxton)ENSG00000158669 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000158669 [Gene_View]  chr8:41578188-41625001 [Contig_View]  GPAT4 [Vega]
ICGC DataPortalENSG00000158669
TCGA cBioPortalGPAT4
AceView (NCBI)GPAT4
Genatlas (Paris)GPAT4
WikiGenes137964
SOURCE (Princeton)GPAT4
Genetics Home Reference (NIH)GPAT4
Genomic and cartography
GoldenPath hg38 (UCSC)GPAT4  -     chr8:41578188-41625001 +  8p11.21   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)GPAT4  -     8p11.21   [Description]    (hg19-Feb_2009)
EnsemblGPAT4 - 8p11.21 [CytoView hg19]  GPAT4 - 8p11.21 [CytoView hg38]
Mapping of homologs : NCBIGPAT4 [Mapview hg19]  GPAT4 [Mapview hg38]
OMIM608143   
Gene and transcription
Genbank (Entrez)AF317516 AF406612 AL834255 AY358670 AY513610
RefSeq transcript (Entrez)NM_178819
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)GPAT4
Cluster EST : UnigeneHs.355753 [ NCBI ]
CGAP (NCI)Hs.355753
Alternative Splicing GalleryENSG00000158669
Gene ExpressionGPAT4 [ NCBI-GEO ]   GPAT4 [ EBI - ARRAY_EXPRESS ]   GPAT4 [ SEEK ]   GPAT4 [ MEM ]
Gene Expression Viewer (FireBrowse)GPAT4 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevestigatorExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)137964
GTEX Portal (Tissue expression)GPAT4
Human Protein AtlasENSG00000158669-GPAT4 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ86UL3   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ86UL3  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ86UL3
Splice isoforms : SwissVarQ86UL3
Catalytic activity : Enzyme2.3.1.15 [ Enzyme-Expasy ]   2.3.1.152.3.1.15 [ IntEnz-EBI ]   2.3.1.15 [ BRENDA ]   2.3.1.15 [ KEGG ]   
PhosPhoSitePlusQ86UL3
Domains : Interpro (EBI)Plipid/glycerol_acylTrfase   
Domain families : Pfam (Sanger)Acyltransferase (PF01553)   
Domain families : Pfam (NCBI)pfam01553   
Domain families : Smart (EMBL)PlsC (SM00563)  
Conserved Domain (NCBI)GPAT4
DMDM Disease mutations137964
Blocks (Seattle)GPAT4
SuperfamilyQ86UL3
Human Protein Atlas [tissue]ENSG00000158669-GPAT4 [tissue]
Peptide AtlasQ86UL3
HPRD12175
IPIIPI00016070   IPI00978987   IPI00982342   IPI00982997   
Protein Interaction databases
DIP (DOE-UCLA)Q86UL3
IntAct (EBI)Q86UL3
FunCoupENSG00000158669
BioGRIDGPAT4
STRING (EMBL)GPAT4
ZODIACGPAT4
Ontologies - Pathways
QuickGOQ86UL3
Ontology : AmiGOglandular epithelial cell maturation  1-acylglycerol-3-phosphate O-acyltransferase activity  1-acylglycerol-3-phosphate O-acyltransferase activity  glycerol-3-phosphate O-acyltransferase activity  glycerol-3-phosphate O-acyltransferase activity  endoplasmic reticulum  endoplasmic reticulum  endoplasmic reticulum membrane  fatty acid metabolic process  acyl-CoA metabolic process  phosphatidic acid biosynthetic process  phosphatidylcholine biosynthetic process  lactation  lipid biosynthetic process  membrane  integral component of membrane  CDP-diacylglycerol biosynthetic process  triglyceride biosynthetic process  triglyceride biosynthetic process  triglyceride biosynthetic process  regulation of multicellular organism growth  diacylglycerol metabolic process  
Ontology : EGO-EBIglandular epithelial cell maturation  1-acylglycerol-3-phosphate O-acyltransferase activity  1-acylglycerol-3-phosphate O-acyltransferase activity  glycerol-3-phosphate O-acyltransferase activity  glycerol-3-phosphate O-acyltransferase activity  endoplasmic reticulum  endoplasmic reticulum  endoplasmic reticulum membrane  fatty acid metabolic process  acyl-CoA metabolic process  phosphatidic acid biosynthetic process  phosphatidylcholine biosynthetic process  lactation  lipid biosynthetic process  membrane  integral component of membrane  CDP-diacylglycerol biosynthetic process  triglyceride biosynthetic process  triglyceride biosynthetic process  triglyceride biosynthetic process  regulation of multicellular organism growth  diacylglycerol metabolic process  
NDEx NetworkGPAT4
Atlas of Cancer Signalling NetworkGPAT4
Wikipedia pathwaysGPAT4
Orthology - Evolution
OrthoDB137964
GeneTree (enSembl)ENSG00000158669
Phylogenetic Trees/Animal Genes : TreeFamGPAT4
HOVERGENQ86UL3
HOGENOMQ86UL3
Homologs : HomoloGeneGPAT4
Homology/Alignments : Family Browser (UCSC)GPAT4
Gene fusions - Rearrangements
Tumor Fusion PortalGPAT4
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerGPAT4 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)GPAT4
dbVarGPAT4
ClinVarGPAT4
1000_GenomesGPAT4 
Exome Variant ServerGPAT4
ExAC (Exome Aggregation Consortium)ENSG00000158669
GNOMAD BrowserENSG00000158669
Genetic variants : HAPMAP137964
Genomic Variants (DGV)GPAT4 [DGVbeta]
DECIPHERGPAT4 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisGPAT4 
Mutations
ICGC Data PortalGPAT4 
TCGA Data PortalGPAT4 
Broad Tumor PortalGPAT4
OASIS PortalGPAT4 [ Somatic mutations - Copy number]
Mutations and Diseases : HGMDGPAT4
BioMutasearch GPAT4
DgiDB (Drug Gene Interaction Database)GPAT4
DoCM (Curated mutations)GPAT4 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)GPAT4 (select a term)
intoGenGPAT4
Cancer3DGPAT4(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM608143   
Orphanet
DisGeNETGPAT4
MedgenGPAT4
Genetic Testing Registry GPAT4
NextProtQ86UL3 [Medical]
TSGene137964
GENETestsGPAT4
Target ValidationGPAT4
Huge Navigator GPAT4 [HugePedia]
snp3D : Map Gene to Disease137964
BioCentury BCIQGPAT4
ClinGenGPAT4
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD137964
Chemical/Pharm GKB GenePA142672637
Clinical trialGPAT4
Miscellaneous
canSAR (ICR)GPAT4 (select the gene name)
Probes
Litterature
PubMed16 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineGPAT4
EVEXGPAT4
GoPubMedGPAT4
iHOPGPAT4
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Tue Nov 21 13:18:13 CET 2017

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