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GPC4 (glypican 4)

Identity

Alias_symbol (synonym)K-glypican
Other alias
HGNC (Hugo) GPC4
LocusID (NCBI) 2239
Atlas_Id 40736
Location Xq26.2  [Link to chromosome band Xq26]
Location_base_pair Starts at 132435064 and ends at 132549205 bp from pter ( according to hg19-Feb_2009)
Fusion genes
(updated 2016)
ATXN1L (16q22.2) / GPC4 (Xq26.2)FAM122B (Xq26.3) / GPC4 (Xq26.2)GPC4 (Xq26.2) / BCL2A1 (15q25.1)
GPC4 (Xq26.2) / GPC3 (Xq26.2)FAM122B Xq26.3 / GPC4 Xq26.2GPC4 Xq26.2 / GPC3 Xq26.2

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)GPC4   4452
Cards
Entrez_Gene (NCBI)GPC4  2239  glypican 4
AliasesK-glypican
GeneCards (Weizmann)GPC4
Ensembl hg19 (Hinxton)ENSG00000076716 [Gene_View]  chrX:132435064-132549205 [Contig_View]  GPC4 [Vega]
Ensembl hg38 (Hinxton)ENSG00000076716 [Gene_View]  chrX:132435064-132549205 [Contig_View]  GPC4 [Vega]
ICGC DataPortalENSG00000076716
TCGA cBioPortalGPC4
AceView (NCBI)GPC4
Genatlas (Paris)GPC4
WikiGenes2239
SOURCE (Princeton)GPC4
Genetics Home Reference (NIH)GPC4
Genomic and cartography
GoldenPath hg19 (UCSC)GPC4  -     chrX:132435064-132549205 -  Xq26.2   [Description]    (hg19-Feb_2009)
GoldenPath hg38 (UCSC)GPC4  -     Xq26.2   [Description]    (hg38-Dec_2013)
EnsemblGPC4 - Xq26.2 [CytoView hg19]  GPC4 - Xq26.2 [CytoView hg38]
Mapping of homologs : NCBIGPC4 [Mapview hg19]  GPC4 [Mapview hg38]
OMIM194070   300168   312870   
Gene and transcription
Genbank (Entrez)AF030186 AF064826 AF088063 AK304207 AK312605
RefSeq transcript (Entrez)NM_001448
RefSeq genomic (Entrez)NC_000023 NC_018934 NG_012498 NT_011786 NW_004929446
Consensus coding sequences : CCDS (NCBI)GPC4
Cluster EST : UnigeneHs.58367 [ NCBI ]
CGAP (NCI)Hs.58367
Alternative Splicing GalleryENSG00000076716
Gene ExpressionGPC4 [ NCBI-GEO ]   GPC4 [ EBI - ARRAY_EXPRESS ]   GPC4 [ SEEK ]   GPC4 [ MEM ]
Gene Expression Viewer (FireBrowse)GPC4 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)2239
GTEX Portal (Tissue expression)GPC4
Protein : pattern, domain, 3D structure
UniProt/SwissProtO75487   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtO75487  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProO75487
Splice isoforms : SwissVarO75487
PhosPhoSitePlusO75487
Domaine pattern : Prosite (Expaxy)GLYPICAN (PS01207)   
Domains : Interpro (EBI)Glypican    Glypican-4    Glypican_CS   
Domain families : Pfam (Sanger)Glypican (PF01153)   
Domain families : Pfam (NCBI)pfam01153   
Conserved Domain (NCBI)GPC4
DMDM Disease mutations2239
Blocks (Seattle)GPC4
SuperfamilyO75487
Human Protein AtlasENSG00000076716
Peptide AtlasO75487
HPRD02160
IPIIPI00232571   IPI01015901   IPI01015515   
Protein Interaction databases
DIP (DOE-UCLA)O75487
IntAct (EBI)O75487
FunCoupENSG00000076716
BioGRIDGPC4
STRING (EMBL)GPC4
ZODIACGPC4
Ontologies - Pathways
QuickGOO75487
Ontology : AmiGOretinoid metabolic process  proteinaceous extracellular matrix  extracellular space  nucleus  Golgi lumen  plasma membrane  integral component of plasma membrane  glycosaminoglycan biosynthetic process  glycosaminoglycan catabolic process  cell proliferation  anatomical structure morphogenesis  external side of plasma membrane  glycosaminoglycan metabolic process  anchored component of membrane  lysosomal lumen  heparan sulfate proteoglycan binding  Wnt signaling pathway, planar cell polarity pathway  extracellular exosome  coreceptor activity involved in Wnt signaling pathway, planar cell polarity pathway  
Ontology : EGO-EBIretinoid metabolic process  proteinaceous extracellular matrix  extracellular space  nucleus  Golgi lumen  plasma membrane  integral component of plasma membrane  glycosaminoglycan biosynthetic process  glycosaminoglycan catabolic process  cell proliferation  anatomical structure morphogenesis  external side of plasma membrane  glycosaminoglycan metabolic process  anchored component of membrane  lysosomal lumen  heparan sulfate proteoglycan binding  Wnt signaling pathway, planar cell polarity pathway  extracellular exosome  coreceptor activity involved in Wnt signaling pathway, planar cell polarity pathway  
Pathways : KEGGWnt signaling pathway   
NDEx NetworkGPC4
Atlas of Cancer Signalling NetworkGPC4
Wikipedia pathwaysGPC4
Orthology - Evolution
OrthoDB2239
GeneTree (enSembl)ENSG00000076716
Phylogenetic Trees/Animal Genes : TreeFamGPC4
HOVERGENO75487
HOGENOMO75487
Homologs : HomoloGeneGPC4
Homology/Alignments : Family Browser (UCSC)GPC4
Gene fusions - Rearrangements
Fusion : MitelmanFAM122B/GPC4 [Xq26.3/Xq26.2]  [t(X;X)(q26;q26)]  
Fusion : MitelmanGPC4/GPC3 [Xq26.2/Xq26.2]  [t(X;X)(q26;q26)]  
Fusion: TCGAFAM122B Xq26.3 GPC4 Xq26.2 BRCA
Fusion: TCGAGPC4 Xq26.2 GPC3 Xq26.2 BRCA
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerGPC4 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)GPC4
dbVarGPC4
ClinVarGPC4
1000_GenomesGPC4 
Exome Variant ServerGPC4
ExAC (Exome Aggregation Consortium)GPC4 (select the gene name)
Genetic variants : HAPMAP2239
Genomic Variants (DGV)GPC4 [DGVbeta]
DECIPHER (Syndromes)X:132435064-132549205  ENSG00000076716
CONAN: Copy Number AnalysisGPC4 
Mutations
ICGC Data PortalGPC4 
TCGA Data PortalGPC4 
Broad Tumor PortalGPC4
OASIS PortalGPC4 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICGPC4  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDGPC4
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
LOVD (Leiden Open Variation Database)X-chromosome gene database
BioMutasearch GPC4
DgiDB (Drug Gene Interaction Database)GPC4
DoCM (Curated mutations)GPC4 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)GPC4 (select a term)
intoGenGPC4
Cancer3DGPC4(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM194070    300168    312870   
Orphanet912   
MedgenGPC4
Genetic Testing Registry GPC4
NextProtO75487 [Medical]
TSGene2239
GENETestsGPC4
Huge Navigator GPC4 [HugePedia]
snp3D : Map Gene to Disease2239
BioCentury BCIQGPC4
ClinGenGPC4
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD2239
Chemical/Pharm GKB GenePA28833
Clinical trialGPC4
Miscellaneous
canSAR (ICR)GPC4 (select the gene name)
Probes
Litterature
PubMed34 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineGPC4
EVEXGPC4
GoPubMedGPC4
iHOPGPC4
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Thu Mar 30 15:02:50 CEST 2017

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