Atlas of Genetics and Cytogenetics in Oncology and Haematology


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GPC4 (glypican 4)

Identity

Alias (NCBI)K-glypican
KPTS
HGNC (Hugo) GPC4
HGNC Alias symbK-glypican
HGNC Alias nameglypican proteoglycan 4
LocusID (NCBI) 2239
Atlas_Id 40736
Location Xq26.2  [Link to chromosome band Xq26]
Location_base_pair Starts at 133300103 and ends at 133415489 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
ATXN1L (16q22.2) / GPC4 (Xq26.2)FAM122B (Xq26.3) / GPC4 (Xq26.2)GPC4 (Xq26.2) / BCL2A1 (15q25.1)
GPC4 (Xq26.2) / GPC3 (Xq26.2)FAM122B Xq26.3 / GPC4 Xq26.2GPC4 Xq26.2 / GPC3 Xq26.2

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 



External links

 

Nomenclature
HGNC (Hugo)GPC4   4452
Cards
Entrez_Gene (NCBI)GPC4    glypican 4
AliasesK-glypican; KPTS
GeneCards (Weizmann)GPC4
Ensembl hg19 (Hinxton)ENSG00000076716 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000076716 [Gene_View]  ENSG00000076716 [Sequence]  chrX:133300103-133415489 [Contig_View]  GPC4 [Vega]
ICGC DataPortalENSG00000076716
TCGA cBioPortalGPC4
AceView (NCBI)GPC4
Genatlas (Paris)GPC4
SOURCE (Princeton)GPC4
Genetics Home Reference (NIH)GPC4
Genomic and cartography
GoldenPath hg38 (UCSC)GPC4  -     chrX:133300103-133415489 -  Xq26.2   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)GPC4  -     Xq26.2   [Description]    (hg19-Feb_2009)
GoldenPathGPC4 - Xq26.2 [CytoView hg19]  GPC4 - Xq26.2 [CytoView hg38]
ImmunoBaseENSG00000076716
Genome Data Viewer NCBIGPC4 [Mapview hg19]  
OMIM194070   300168   301026   312870   
Gene and transcription
Genbank (Entrez)AF030186 AF064826 AF088063 AK304207 AK312605
RefSeq transcript (Entrez)NM_001448
Consensus coding sequences : CCDS (NCBI)GPC4
Gene ExpressionGPC4 [ NCBI-GEO ]   GPC4 [ EBI - ARRAY_EXPRESS ]   GPC4 [ SEEK ]   GPC4 [ MEM ]
Gene Expression Viewer (FireBrowse)GPC4 [ Firebrowse - Broad ]
GenevisibleExpression of GPC4 in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)2239
GTEX Portal (Tissue expression)GPC4
Human Protein AtlasENSG00000076716-GPC4 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtO75487   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtO75487  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProO75487
PhosPhoSitePlusO75487
Domaine pattern : Prosite (Expaxy)GLYPICAN (PS01207)   
Domains : Interpro (EBI)Glypican    Glypican-4    Glypican_CS   
Domain families : Pfam (Sanger)Glypican (PF01153)   
Domain families : Pfam (NCBI)pfam01153   
Conserved Domain (NCBI)GPC4
SuperfamilyO75487
AlphaFold pdb e-kbO75487   
Human Protein Atlas [tissue]ENSG00000076716-GPC4 [tissue]
HPRD02160
Protein Interaction databases
DIP (DOE-UCLA)O75487
IntAct (EBI)O75487
BioGRIDGPC4
STRING (EMBL)GPC4
ZODIACGPC4
Ontologies - Pathways
QuickGOO75487
Ontology : AmiGOretinoid metabolic process  protein binding  nucleus  Golgi lumen  plasma membrane  glycosaminoglycan biosynthetic process  glycosaminoglycan catabolic process  external side of plasma membrane  regulation of signal transduction  cell surface  Wnt signaling pathway  cell migration  lysosomal lumen  synapse  Wnt signaling pathway, planar cell polarity pathway  collagen-containing extracellular matrix  extracellular exosome  regulation of neurotransmitter receptor localization to postsynaptic specialization membrane  glutamatergic synapse  anchored component of presynaptic membrane  synaptic membrane adhesion  coreceptor activity involved in Wnt signaling pathway, planar cell polarity pathway  regulation of protein localization to membrane  regulation of presynapse assembly  
Ontology : EGO-EBIretinoid metabolic process  protein binding  nucleus  Golgi lumen  plasma membrane  glycosaminoglycan biosynthetic process  glycosaminoglycan catabolic process  external side of plasma membrane  regulation of signal transduction  cell surface  Wnt signaling pathway  cell migration  lysosomal lumen  synapse  Wnt signaling pathway, planar cell polarity pathway  collagen-containing extracellular matrix  extracellular exosome  regulation of neurotransmitter receptor localization to postsynaptic specialization membrane  glutamatergic synapse  anchored component of presynaptic membrane  synaptic membrane adhesion  coreceptor activity involved in Wnt signaling pathway, planar cell polarity pathway  regulation of protein localization to membrane  regulation of presynapse assembly  
Pathways : KEGGWnt signaling pathway   
NDEx NetworkGPC4
Atlas of Cancer Signalling NetworkGPC4
Wikipedia pathwaysGPC4
Orthology - Evolution
OrthoDB2239
GeneTree (enSembl)ENSG00000076716
Phylogenetic Trees/Animal Genes : TreeFamGPC4
Homologs : HomoloGeneGPC4
Homology/Alignments : Family Browser (UCSC)GPC4
Gene fusions - Rearrangements
Fusion : MitelmanFAM122B/GPC4 [Xq26.3/Xq26.2]  
Fusion : MitelmanGPC4/GPC3 [Xq26.2/Xq26.2]  
Fusion : QuiverGPC4
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerGPC4 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)GPC4
dbVarGPC4
ClinVarGPC4
MonarchGPC4
1000_GenomesGPC4 
Exome Variant ServerGPC4
GNOMAD BrowserENSG00000076716
Varsome BrowserGPC4
ACMGGPC4 variants
VarityO75487
Genomic Variants (DGV)GPC4 [DGVbeta]
DECIPHERGPC4 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisGPC4 
Mutations
ICGC Data PortalGPC4 
TCGA Data PortalGPC4 
Broad Tumor PortalGPC4
OASIS PortalGPC4 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICGPC4  [overview]  [genome browser]  [tissue]  [distribution]  
Somatic Mutations in Cancer : COSMIC3DGPC4
Mutations and Diseases : HGMDGPC4
LOVD (Leiden Open Variation Database)[gene] [transcripts] [variants]
BioMutaGPC4
DgiDB (Drug Gene Interaction Database)GPC4
DoCM (Curated mutations)GPC4
CIViC (Clinical Interpretations of Variants in Cancer)GPC4
Cancer3DGPC4
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM194070    300168    301026    312870   
Orphanet912   
DisGeNETGPC4
MedgenGPC4
Genetic Testing Registry GPC4
NextProtO75487 [Medical]
GENETestsGPC4
Target ValidationGPC4
Huge Navigator GPC4 [HugePedia]
ClinGenGPC4
Clinical trials, drugs, therapy
MyCancerGenomeGPC4
Protein Interactions : CTDGPC4
Pharm GKB GenePA28833
PharosO75487
Clinical trialGPC4
Miscellaneous
canSAR (ICR)GPC4
HarmonizomeGPC4
DataMed IndexGPC4
Probes
Litterature
PubMed57 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
EVEXGPC4
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Mon Oct 4 15:11:15 CEST 2021

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