Atlas of Genetics and Cytogenetics in Oncology and Haematology


Home   Genes   Leukemias   Solid Tumors   Cancer-Prone   Deep Insight   Case Reports   Journals  Portal   Teaching   

X Y 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 NA

GPC6 (glypican 6)

Identity

Alias (NCBI)OMIMD1
HGNC (Hugo) GPC6
HGNC Alias nameglypican proteoglycan 6
LocusID (NCBI) 10082
Atlas_Id 55080
Location 13q31.3  [Link to chromosome band 13q31]
Location_base_pair Starts at 93226807 and ends at 94408019 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
CFH (1q31.3) / GPC6 (13q31.3)DNAJC3 (13q32.1) / GPC6 (13q31.3)FARP1 (13q32.2) / GPC6 (13q31.3)
GPC6 (13q31.3) / GCHFR (15q15.1)GPC6 (13q31.3) / GPC5 (13q31.3)GPC6 (13q31.3) / GPC6 (13q31.3)
GPC6 (13q31.3) / MPHOSPH8 (13q12.11)GPR180 (13q32.1) / GPC6 (13q31.3)PLEKHA5 (12p12.3) / GPC6 (13q31.3)
DNAJC3 13q32.1 / GPC6 13q31.3FARP1 13q32.2 / GPC6 13q31.3GPC6 13q31.3 / GPC5 13q31.3
PLEKHA5 12p12.3 / GPC6 13q31.3

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 



External links

 

Nomenclature
HGNC (Hugo)GPC6   4454
Cards
Entrez_Gene (NCBI)GPC6    glypican 6
AliasesOMIMD1
GeneCards (Weizmann)GPC6
Ensembl hg19 (Hinxton)ENSG00000183098 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000183098 [Gene_View]  ENSG00000183098 [Sequence]  chr13:93226807-94408019 [Contig_View]  GPC6 [Vega]
ICGC DataPortalENSG00000183098
TCGA cBioPortalGPC6
AceView (NCBI)GPC6
Genatlas (Paris)GPC6
SOURCE (Princeton)GPC6
Genetics Home Reference (NIH)GPC6
Genomic and cartography
GoldenPath hg38 (UCSC)GPC6  -     chr13:93226807-94408019 +  13q31.3   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)GPC6  -     13q31.3   [Description]    (hg19-Feb_2009)
GoldenPathGPC6 - 13q31.3 [CytoView hg19]  GPC6 - 13q31.3 [CytoView hg38]
ImmunoBaseENSG00000183098
Genome Data Viewer NCBIGPC6 [Mapview hg19]  
OMIM258315   604404   
Gene and transcription
Genbank (Entrez)AF105267 AF111178 AK074741 AK130013 AK290144
RefSeq transcript (Entrez)NM_005708
Consensus coding sequences : CCDS (NCBI)GPC6
Gene ExpressionGPC6 [ NCBI-GEO ]   GPC6 [ EBI - ARRAY_EXPRESS ]   GPC6 [ SEEK ]   GPC6 [ MEM ]
Gene Expression Viewer (FireBrowse)GPC6 [ Firebrowse - Broad ]
GenevisibleExpression of GPC6 in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)10082
GTEX Portal (Tissue expression)GPC6
Human Protein AtlasENSG00000183098-GPC6 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ9Y625   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ9Y625  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ9Y625
PhosPhoSitePlusQ9Y625
Domaine pattern : Prosite (Expaxy)GLYPICAN (PS01207)   
Domains : Interpro (EBI)Glypican    Glypican-6    Glypican_CS   
Domain families : Pfam (Sanger)Glypican (PF01153)   
Domain families : Pfam (NCBI)pfam01153   
Conserved Domain (NCBI)GPC6
SuperfamilyQ9Y625
AlphaFold pdb e-kbQ9Y625   
Human Protein Atlas [tissue]ENSG00000183098-GPC6 [tissue]
HPRD05099
Protein Interaction databases
DIP (DOE-UCLA)Q9Y625
IntAct (EBI)Q9Y625
BioGRIDGPC6
STRING (EMBL)GPC6
ZODIACGPC6
Ontologies - Pathways
QuickGOQ9Y625
Ontology : AmiGOretinoid metabolic process  protein binding  extracellular space  nucleus  Golgi lumen  plasma membrane  glycosaminoglycan biosynthetic process  glycosaminoglycan catabolic process  regulation of signal transduction  cell surface  cell migration  cell migration  lysosomal lumen  synapse  anchored component of plasma membrane  Wnt signaling pathway, planar cell polarity pathway  collagen-containing extracellular matrix  regulation of neurotransmitter receptor localization to postsynaptic specialization membrane  glutamatergic synapse  synaptic membrane adhesion  coreceptor activity involved in Wnt signaling pathway, planar cell polarity pathway  regulation of protein localization to membrane  regulation of presynapse assembly  
Ontology : EGO-EBIretinoid metabolic process  protein binding  extracellular space  nucleus  Golgi lumen  plasma membrane  glycosaminoglycan biosynthetic process  glycosaminoglycan catabolic process  regulation of signal transduction  cell surface  cell migration  cell migration  lysosomal lumen  synapse  anchored component of plasma membrane  Wnt signaling pathway, planar cell polarity pathway  collagen-containing extracellular matrix  regulation of neurotransmitter receptor localization to postsynaptic specialization membrane  glutamatergic synapse  synaptic membrane adhesion  coreceptor activity involved in Wnt signaling pathway, planar cell polarity pathway  regulation of protein localization to membrane  regulation of presynapse assembly  
NDEx NetworkGPC6
Atlas of Cancer Signalling NetworkGPC6
Wikipedia pathwaysGPC6
Orthology - Evolution
OrthoDB10082
GeneTree (enSembl)ENSG00000183098
Phylogenetic Trees/Animal Genes : TreeFamGPC6
Homologs : HomoloGeneGPC6
Homology/Alignments : Family Browser (UCSC)GPC6
Gene fusions - Rearrangements
Fusion : MitelmanDNAJC3/GPC6 [13q32.1/13q31.3]  
Fusion : MitelmanFARP1/GPC6 [13q32.2/13q31.3]  
Fusion : MitelmanGPC6/GPC5 [13q31.3/13q31.3]  
Fusion : MitelmanPLEKHA5/GPC6 [12p12.3/13q31.3]  
Fusion : QuiverGPC6
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerGPC6 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)GPC6
dbVarGPC6
ClinVarGPC6
MonarchGPC6
1000_GenomesGPC6 
Exome Variant ServerGPC6
GNOMAD BrowserENSG00000183098
Varsome BrowserGPC6
ACMGGPC6 variants
VarityQ9Y625
Genomic Variants (DGV)GPC6 [DGVbeta]
DECIPHERGPC6 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisGPC6 
Mutations
ICGC Data PortalGPC6 
TCGA Data PortalGPC6 
Broad Tumor PortalGPC6
OASIS PortalGPC6 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICGPC6  [overview]  [genome browser]  [tissue]  [distribution]  
Somatic Mutations in Cancer : COSMIC3DGPC6
Mutations and Diseases : HGMDGPC6
LOVD (Leiden Open Variation Database)[gene] [transcripts] [variants]
BioMutaGPC6
DgiDB (Drug Gene Interaction Database)GPC6
DoCM (Curated mutations)GPC6
CIViC (Clinical Interpretations of Variants in Cancer)GPC6
Cancer3DGPC6
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM258315    604404   
Orphanet12265   
DisGeNETGPC6
MedgenGPC6
Genetic Testing Registry GPC6
NextProtQ9Y625 [Medical]
GENETestsGPC6
Target ValidationGPC6
Huge Navigator GPC6 [HugePedia]
ClinGenGPC6 (curated)
Clinical trials, drugs, therapy
MyCancerGenomeGPC6
Protein Interactions : CTDGPC6
Pharm GKB GenePA28835
PharosQ9Y625
Clinical trialGPC6
Miscellaneous
canSAR (ICR)GPC6
HarmonizomeGPC6
DataMed IndexGPC6
Probes
Litterature
PubMed44 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
EVEXGPC6
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

Search in all EBI   NCBI

© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Mon Oct 4 15:11:15 CEST 2021

Home   Genes   Leukemias   Solid Tumors   Cancer-Prone   Deep Insight   Case Reports   Journals  Portal   Teaching   

For comments and suggestions or contributions, please contact us

jlhuret@AtlasGeneticsOncology.org.