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GPD2 (glycerol-3-phosphate dehydrogenase 2)

Identity

Alias_namesglycerol-3-phosphate dehydrogenase 2 (mitochondrial)
Other aliasGDH2
GPDM
mGPDH
HGNC (Hugo) GPD2
LocusID (NCBI) 2820
Atlas_Id 43732
Location 2q24.1  [Link to chromosome band 2q24]
Location_base_pair Starts at 156436388 and ends at 156586403 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2016)
ENY2 (8q23.1) / GPD2 (2q24.1)GPD2 (2q24.1) / RASAL2 (1q25.2)GPD2 (2q24.1) / RPS27A (2p16.1)
WDSUB1 (2q24.2) / GPD2 (2q24.1)WDSUB1 2q24.2 / GPD2 2q24.1

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)GPD2   4456
Cards
Entrez_Gene (NCBI)GPD2  2820  glycerol-3-phosphate dehydrogenase 2
AliasesGDH2; GPDM; mGPDH
GeneCards (Weizmann)GPD2
Ensembl hg19 (Hinxton)ENSG00000115159 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000115159 [Gene_View]  chr2:156436388-156586403 [Contig_View]  GPD2 [Vega]
ICGC DataPortalENSG00000115159
TCGA cBioPortalGPD2
AceView (NCBI)GPD2
Genatlas (Paris)GPD2
WikiGenes2820
SOURCE (Princeton)GPD2
Genetics Home Reference (NIH)GPD2
Genomic and cartography
GoldenPath hg38 (UCSC)GPD2  -     chr2:156436388-156586403 +  2q24.1   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)GPD2  -     2q24.1   [Description]    (hg19-Feb_2009)
EnsemblGPD2 - 2q24.1 [CytoView hg19]  GPD2 - 2q24.1 [CytoView hg38]
Mapping of homologs : NCBIGPD2 [Mapview hg19]  GPD2 [Mapview hg38]
OMIM125853   138430   
Gene and transcription
Genbank (Entrez)AB209399 AF311325 AK022596 AK027840 AK093198
RefSeq transcript (Entrez)NM_000408 NM_001083112
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)GPD2
Cluster EST : UnigeneHs.512382 [ NCBI ]
CGAP (NCI)Hs.512382
Alternative Splicing GalleryENSG00000115159
Gene ExpressionGPD2 [ NCBI-GEO ]   GPD2 [ EBI - ARRAY_EXPRESS ]   GPD2 [ SEEK ]   GPD2 [ MEM ]
Gene Expression Viewer (FireBrowse)GPD2 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)2820
GTEX Portal (Tissue expression)GPD2
Protein : pattern, domain, 3D structure
UniProt/SwissProtP43304   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtP43304  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProP43304
Splice isoforms : SwissVarP43304
Catalytic activity : Enzyme1.1.5.3 [ Enzyme-Expasy ]   1.1.5.31.1.5.3 [ IntEnz-EBI ]   1.1.5.3 [ BRENDA ]   1.1.5.3 [ KEGG ]   
PhosPhoSitePlusP43304
Domaine pattern : Prosite (Expaxy)EF_HAND_1 (PS00018)    EF_HAND_2 (PS50222)    FAD_G3PDH_1 (PS00977)    FAD_G3PDH_2 (PS00978)   
Domains : Interpro (EBI)DAO_C    EF-hand-dom_pair    EF_Hand_1_Ca_BS    EF_hand_dom    FAD-dep_OxRdtase    FAD/NAD-binding_dom    G3P_DH_FAD-dep   
Domain families : Pfam (Sanger)DAO (PF01266)    DAO_C (PF16901)    EF-hand_7 (PF13499)   
Domain families : Pfam (NCBI)pfam01266    pfam16901    pfam13499   
Domain families : Smart (EMBL)EFh (SM00054)  
Conserved Domain (NCBI)GPD2
DMDM Disease mutations2820
Blocks (Seattle)GPD2
SuperfamilyP43304
Human Protein AtlasENSG00000115159
Peptide AtlasP43304
HPRD00715
IPIIPI00017895   IPI00719611   IPI00915789   IPI01026538   IPI00917874   
Protein Interaction databases
DIP (DOE-UCLA)P43304
IntAct (EBI)P43304
FunCoupENSG00000115159
BioGRIDGPD2
STRING (EMBL)GPD2
ZODIACGPD2
Ontologies - Pathways
QuickGOP43304
Ontology : AmiGOglycerol-3-phosphate dehydrogenase activity  calcium ion binding  mitochondrial inner membrane  glycerol-3-phosphate metabolic process  gluconeogenesis  glycerol-3-phosphate dehydrogenase complex  glycerol catabolic process  multicellular organism growth  camera-type eye development  cellular lipid metabolic process  sn-glycerol-3-phosphate:ubiquinone-8 oxidoreductase activity  oxidation-reduction process  
Ontology : EGO-EBIglycerol-3-phosphate dehydrogenase activity  calcium ion binding  mitochondrial inner membrane  glycerol-3-phosphate metabolic process  gluconeogenesis  glycerol-3-phosphate dehydrogenase complex  glycerol catabolic process  multicellular organism growth  camera-type eye development  cellular lipid metabolic process  sn-glycerol-3-phosphate:ubiquinone-8 oxidoreductase activity  oxidation-reduction process  
Pathways : BIOCARTAElectron Transport Reaction in Mitochondria [Genes]   
Pathways : KEGGGlycerophospholipid metabolism   
NDEx NetworkGPD2
Atlas of Cancer Signalling NetworkGPD2
Wikipedia pathwaysGPD2
Orthology - Evolution
OrthoDB2820
GeneTree (enSembl)ENSG00000115159
Phylogenetic Trees/Animal Genes : TreeFamGPD2
HOVERGENP43304
HOGENOMP43304
Homologs : HomoloGeneGPD2
Homology/Alignments : Family Browser (UCSC)GPD2
Gene fusions - Rearrangements
Fusion : MitelmanWDSUB1/GPD2 [2q24.2/2q24.1]  [t(2;2)(q24;q24)]  
Fusion: TCGAWDSUB1 2q24.2 GPD2 2q24.1 BLCA
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerGPD2 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)GPD2
dbVarGPD2
ClinVarGPD2
1000_GenomesGPD2 
Exome Variant ServerGPD2
ExAC (Exome Aggregation Consortium)GPD2 (select the gene name)
Genetic variants : HAPMAP2820
Genomic Variants (DGV)GPD2 [DGVbeta]
DECIPHERGPD2 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisGPD2 
Mutations
ICGC Data PortalGPD2 
TCGA Data PortalGPD2 
Broad Tumor PortalGPD2
OASIS PortalGPD2 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICGPD2  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDGPD2
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
LOVD (Leiden Open Variation Database)MSeqDR-LSDB Mitochondrial Disease Locus Specific Database
BioMutasearch GPD2
DgiDB (Drug Gene Interaction Database)GPD2
DoCM (Curated mutations)GPD2 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)GPD2 (select a term)
intoGenGPD2
Cancer3DGPD2(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM125853    138430   
Orphanet
MedgenGPD2
Genetic Testing Registry GPD2
NextProtP43304 [Medical]
TSGene2820
GENETestsGPD2
Target ValidationGPD2
Huge Navigator GPD2 [HugePedia]
snp3D : Map Gene to Disease2820
BioCentury BCIQGPD2
ClinGenGPD2
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD2820
Chemical/Pharm GKB GenePA28837
Clinical trialGPD2
Miscellaneous
canSAR (ICR)GPD2 (select the gene name)
Probes
Litterature
PubMed32 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineGPD2
EVEXGPD2
GoPubMedGPD2
iHOPGPD2
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Wed Jun 7 12:35:47 CEST 2017

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