GPHB5 (glycoprotein hormone subunit beta 5)

2014-11-01  

Identity

HGNC
LOCATION
14q23.2
LOCUSID
ALIAS
B5,GPB5,ZLUT1

Other Information

Locus ID:

NCBI: 122876
MIM: 609652
HGNC: 18055
Ensembl: ENSG00000179600

Variants:

dbSNP: 122876
ClinVar: 122876
TCGA: ENSG00000179600
COSMIC: GPHB5

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000179600ENST00000314140Q86YW7
ENSG00000179600ENST00000314140A0A0F7RPU1
ENSG00000179600ENST00000621500Q86YW7
ENSG00000179600ENST00000621500A0A0F7RPU1

Expression (GTEx)

0
1

Pathways

PathwaySourceExternal ID
Signal TransductionREACTOMER-HSA-162582
Signaling by GPCRREACTOMER-HSA-372790
GPCR ligand bindingREACTOMER-HSA-500792
Class A/1 (Rhodopsin-like receptors)REACTOMER-HSA-373076
Hormone ligand-binding receptorsREACTOMER-HSA-375281
GPCR downstream signalingREACTOMER-HSA-388396
G alpha (s) signalling eventsREACTOMER-HSA-418555

References

Pubmed IDYearTitleCitations
120452582002Thyrostimulin, a heterodimer of two new human glycoprotein hormone subunits, activates the thyroid-stimulating hormone receptor.36
158907692005Heterodimeric fly glycoprotein hormone-alpha2 (GPA2) and glycoprotein hormone-beta5 (GPB5) activate fly leucine-rich repeat-containing G protein-coupled receptor-1 (DLGR1) and stimulation of human thyrotropin receptors by chimeric fly GPA2 and human GPB5.26
120893492002Evolution of glycoprotein hormone subunit genes in bilateral metazoa: identification of two novel human glycoprotein hormone subunit family genes, GPA2 and GPB5.24
184338982008Biochemical roles of the oligosaccharide chains in thyrostimulin, a heterodimeric hormone of glycoprotein hormone subunits alpha 2 (GPA2) and beta 5 (GPB5).10
190957382009Inflammatory cytokines regulate glycoprotein subunit beta5 of thyrostimulin through nuclear factor-kappaB.3

Citation

Dessen P

GPHB5 (glycoprotein hormone subunit beta 5)

Atlas Genet Cytogenet Oncol Haematol. 2014-11-01

Online version: http://atlasgeneticsoncology.org/gene/63936/gphb5