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GPI (glucose-6-phosphate isomerase)

Identity

Other namesAMF
GNPI
NLK
PGI
PHI
SA-36
SA36
HGNC (Hugo) GPI
LocusID (NCBI) 2821
Atlas_Id 40737
Location 19q13.11  [Link to chromosome band 19q13]
Location_base_pair Starts at 34856032 and ends at 34893318 bp from pter ( according to hg19-Feb_2009)
Fusion genes
(updated 2016)
ARL15 (5q11.2) / GPI (19q13.11)FDPS (1q22) / GPI (19q13.11)GPI (19q13.11) / CDC37 (19p13.2)
GPI (19q13.11) / FBN1 (15q21.1)GPI (19q13.11) / FDPS (1q22)GPI (19q13.11) / FGF2 (4q27)
GPI (19q13.11) / HDAC8 (Xq13.1)GPI (19q13.11) / MYH11 (16p13.11)GPI (19q13.11) / NFKB2 (10q24.32)
GPI (19q13.11) / STAR (8p11.23)GPI (19q13.11) / TM2D1 (1p31.3)GPI (19q13.11) / ZNF362 (1p35.1)
PHYKPL (5q35.3) / GPI (19q13.11)UBA2 (19q13.11) / GPI (19q13.11)WTIP (19q13.11) / GPI (19q13.11)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)GPI   4458
Cards
Entrez_Gene (NCBI)GPI  2821  glucose-6-phosphate isomerase
AliasesAMF; GNPI; NLK; PGI; 
PHI; SA-36; SA36
GeneCards (Weizmann)GPI
Ensembl hg19 (Hinxton)ENSG00000105220 [Gene_View]  chr19:34856032-34893318 [Contig_View]  GPI [Vega]
Ensembl hg38 (Hinxton)ENSG00000105220 [Gene_View]  chr19:34856032-34893318 [Contig_View]  GPI [Vega]
ICGC DataPortalENSG00000105220
TCGA cBioPortalGPI
AceView (NCBI)GPI
Genatlas (Paris)GPI
WikiGenes2821
SOURCE (Princeton)GPI
Genomic and cartography
GoldenPath hg19 (UCSC)GPI  -     chr19:34856032-34893318 +  19q13.11   [Description]    (hg19-Feb_2009)
GoldenPath hg38 (UCSC)GPI  -     19q13.11   [Description]    (hg38-Dec_2013)
EnsemblGPI - 19q13.11 [CytoView hg19]  GPI - 19q13.11 [CytoView hg38]
Mapping of homologs : NCBIGPI [Mapview hg19]  GPI [Mapview hg38]
OMIM172400   613470   
Gene and transcription
Genbank (Entrez)AB209575 AK025421 AK129884 AK130102 AK293446
RefSeq transcript (Entrez)NM_000175 NM_001184722 NM_001289789 NM_001289790
RefSeq genomic (Entrez)NC_000019 NC_018930 NG_012838 NT_011109 NT_187619 NW_004929415
Consensus coding sequences : CCDS (NCBI)GPI
Cluster EST : UnigeneHs.515344 [ NCBI ]
CGAP (NCI)Hs.515344
Alternative Splicing GalleryENSG00000105220
Gene ExpressionGPI [ NCBI-GEO ]   GPI [ EBI - ARRAY_EXPRESS ]   GPI [ SEEK ]   GPI [ MEM ]
Gene Expression Viewer (FireBrowse)GPI [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)2821
GTEX Portal (Tissue expression)GPI
Protein : pattern, domain, 3D structure
UniProt/SwissProtP06744 (Uniprot)
NextProtP06744  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProP06744
Splice isoforms : SwissVarP06744 (Swissvar)
Catalytic activity : Enzyme5.3.1.9 [ Enzyme-Expasy ]   5.3.1.95.3.1.9 [ IntEnz-EBI ]   5.3.1.9 [ BRENDA ]   5.3.1.9 [ KEGG ]   
PhosPhoSitePlusP06744
Domaine pattern : Prosite (Expaxy)P_GLUCOSE_ISOMERASE_1 (PS00765)    P_GLUCOSE_ISOMERASE_2 (PS00174)    P_GLUCOSE_ISOMERASE_3 (PS51463)   
Domains : Interpro (EBI)G6P_Isomerase    G6P_Isomerase_C    Phosphoglucose_isomerase_CS   
Domain families : Pfam (Sanger)PGI (PF00342)   
Domain families : Pfam (NCBI)pfam00342   
DMDM Disease mutations2821
Blocks (Seattle)GPI
PDB (SRS)1IAT    1IRI    1JIQ    1JLH    1NUH   
PDB (PDBSum)1IAT    1IRI    1JIQ    1JLH    1NUH   
PDB (IMB)1IAT    1IRI    1JIQ    1JLH    1NUH   
PDB (RSDB)1IAT    1IRI    1JIQ    1JLH    1NUH   
Structural Biology KnowledgeBase1IAT    1IRI    1JIQ    1JLH    1NUH   
SCOP (Structural Classification of Proteins)1IAT    1IRI    1JIQ    1JLH    1NUH   
CATH (Classification of proteins structures)1IAT    1IRI    1JIQ    1JLH    1NUH   
SuperfamilyP06744
Human Protein AtlasENSG00000105220
Peptide AtlasP06744
HPRD01394
IPIIPI00027497   IPI00908881   IPI00556013   IPI00910781   
Protein Interaction databases
DIP (DOE-UCLA)P06744
IntAct (EBI)P06744
FunCoupENSG00000105220
BioGRIDGPI
STRING (EMBL)GPI
ZODIACGPI
Ontologies - Pathways
QuickGOP06744
Ontology : AmiGOangiogenesis  in utero embryonic development  mesoderm formation  glucose-6-phosphate isomerase activity  cytokine activity  extracellular space  nucleoplasm  cytoplasm  cytosol  plasma membrane  carbohydrate metabolic process  gluconeogenesis  humoral immune response  hemostasis  learning or memory  growth factor activity  membrane  intramolecular transferase activity  methylglyoxal biosynthetic process  ubiquitin protein ligase binding  erythrocyte homeostasis  glucose homeostasis  neuron projection  negative regulation of cysteine-type endopeptidase activity involved in apoptotic process  myelin sheath  negative regulation of neuron apoptotic process  aldehyde catabolic process  monosaccharide binding  glucose 6-phosphate metabolic process  ciliary membrane  canonical glycolysis  extracellular exosome  
Ontology : EGO-EBIangiogenesis  in utero embryonic development  mesoderm formation  glucose-6-phosphate isomerase activity  cytokine activity  extracellular space  nucleoplasm  cytoplasm  cytosol  plasma membrane  carbohydrate metabolic process  gluconeogenesis  humoral immune response  hemostasis  learning or memory  growth factor activity  membrane  intramolecular transferase activity  methylglyoxal biosynthetic process  ubiquitin protein ligase binding  erythrocyte homeostasis  glucose homeostasis  neuron projection  negative regulation of cysteine-type endopeptidase activity involved in apoptotic process  myelin sheath  negative regulation of neuron apoptotic process  aldehyde catabolic process  monosaccharide binding  glucose 6-phosphate metabolic process  ciliary membrane  canonical glycolysis  extracellular exosome  
Pathways : BIOCARTAGlycolysis Pathway [Genes]   
Pathways : KEGGGlycolysis / Gluconeogenesis    Pentose phosphate pathway    Starch and sucrose metabolism    Amino sugar and nucleotide sugar metabolism   
NDEx NetworkGPI
Atlas of Cancer Signalling NetworkGPI
Wikipedia pathwaysGPI
Orthology - Evolution
OrthoDB2821
GeneTree (enSembl)ENSG00000105220
Phylogenetic Trees/Animal Genes : TreeFamGPI
Homologs : HomoloGeneGPI
Homology/Alignments : Family Browser (UCSC)GPI
Gene fusions - Rearrangements
Polymorphisms : SNP, variants
NCBI Variation ViewerGPI [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)GPI
dbVarGPI
ClinVarGPI
1000_GenomesGPI 
Exome Variant ServerGPI
ExAC (Exome Aggregation Consortium)GPI (select the gene name)
Genetic variants : HAPMAP2821
Genomic Variants (DGV)GPI [DGVbeta]
Mutations
ICGC Data PortalGPI 
TCGA Data PortalGPI 
Broad Tumor PortalGPI
OASIS PortalGPI [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICGPI 
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch GPI
DgiDB (Drug Gene Interaction Database)GPI
DoCM (Curated mutations)GPI (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)GPI (select a term)
intoGenGPI
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] 
Diseases
DECIPHER (Syndromes)19:34856032-34893318  ENSG00000105220
CONAN: Copy Number AnalysisGPI 
Mutations and Diseases : HGMDGPI
OMIM172400    613470   
MedgenGPI
Genetic Testing Registry GPI
NextProtP06744 [Medical]
TSGene2821
GENETestsGPI
Huge Navigator GPI [HugePedia]
snp3D : Map Gene to Disease2821
BioCentury BCIQGPI
ClinGenGPI
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD2821
Chemical/Pharm GKB GenePA28841
Clinical trialGPI
Miscellaneous
canSAR (ICR)GPI (select the gene name)
Probes
Litterature
PubMed97 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineGPI
EVEXGPI
GoPubMedGPI
iHOPGPI
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Mon Sep 19 18:51:30 CEST 2016

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