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GPLD1 (glycosylphosphatidylinositol specific phospholipase D1)

Identity

Other aliasGPIPLD
GPIPLDM
PIGPLD
PIGPLD1
PLD
HGNC (Hugo) GPLD1
LocusID (NCBI) 2822
Atlas_Id 40738
Location 6p22.3  [Link to chromosome band 6p22]
Location_base_pair Starts at 24425834 and ends at 24489622 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
GPLD1 (6p22.3) / ALDH5A1 (6p22.3)GPLD1 (6p22.3) / TDP2 (6p22.3)GPLD1 6p22.3 / TDP2 6p22.3

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


Other Solid tumors implicated (Data extracted from papers in the Atlas) [ 1 ]
  t(6;6)(p22;p22) GPLD1/TDP2


External links

Nomenclature
HGNC (Hugo)GPLD1   4459
Cards
Entrez_Gene (NCBI)GPLD1  2822  glycosylphosphatidylinositol specific phospholipase D1
AliasesGPIPLD; GPIPLDM; PIGPLD; PIGPLD1; 
PLD
GeneCards (Weizmann)GPLD1
Ensembl hg19 (Hinxton)ENSG00000112293 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000112293 [Gene_View]  ENSG00000112293 [Sequence]  chr6:24425834-24489622 [Contig_View]  GPLD1 [Vega]
ICGC DataPortalENSG00000112293
TCGA cBioPortalGPLD1
AceView (NCBI)GPLD1
Genatlas (Paris)GPLD1
WikiGenes2822
SOURCE (Princeton)GPLD1
Genetics Home Reference (NIH)GPLD1
Genomic and cartography
GoldenPath hg38 (UCSC)GPLD1  -     chr6:24425834-24489622 -  6p22.3   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)GPLD1  -     6p22.3   [Description]    (hg19-Feb_2009)
EnsemblGPLD1 - 6p22.3 [CytoView hg19]  GPLD1 - 6p22.3 [CytoView hg38]
Mapping of homologs : NCBIGPLD1 [Mapview hg19]  GPLD1 [Mapview hg38]
OMIM602515   
Gene and transcription
Genbank (Entrez)AJ308108 AK308639 AK310692 AY007546 BC007614
RefSeq transcript (Entrez)NM_001503 NM_177483
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)GPLD1
Cluster EST : UnigeneHs.533291 [ NCBI ]
CGAP (NCI)Hs.533291
Alternative Splicing GalleryENSG00000112293
Gene ExpressionGPLD1 [ NCBI-GEO ]   GPLD1 [ EBI - ARRAY_EXPRESS ]   GPLD1 [ SEEK ]   GPLD1 [ MEM ]
Gene Expression Viewer (FireBrowse)GPLD1 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevestigatorExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)2822
GTEX Portal (Tissue expression)GPLD1
Human Protein AtlasENSG00000112293-GPLD1 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtP80108   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtP80108  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProP80108
Splice isoforms : SwissVarP80108
Catalytic activity : Enzyme3.1.4.50 [ Enzyme-Expasy ]   3.1.4.503.1.4.50 [ IntEnz-EBI ]   3.1.4.50 [ BRENDA ]   3.1.4.50 [ KEGG ]   
PhosPhoSitePlusP80108
Domaine pattern : Prosite (Expaxy)FG_GAP (PS51470)   
Domains : Interpro (EBI)FG-GAP    Gprt_PLipase_D    Int_alpha_beta-p    PLPC/GPLD1   
Domain families : Pfam (Sanger)FG-GAP (PF01839)    Zn_dep_PLPC (PF00882)   
Domain families : Pfam (NCBI)pfam01839    pfam00882   
Domain families : Smart (EMBL)Int_alpha (SM00191)  
Conserved Domain (NCBI)GPLD1
DMDM Disease mutations2822
Blocks (Seattle)GPLD1
SuperfamilyP80108
Human Protein Atlas [tissue]ENSG00000112293-GPLD1 [tissue]
Peptide AtlasP80108
HPRD03946
IPIIPI00299503   IPI00376358   
Protein Interaction databases
DIP (DOE-UCLA)P80108
IntAct (EBI)P80108
FunCoupENSG00000112293
BioGRIDGPLD1
STRING (EMBL)GPLD1
ZODIACGPLD1
Ontologies - Pathways
QuickGOP80108
Ontology : AmiGOossification  cell migration involved in sprouting angiogenesis  chondrocyte differentiation  complement receptor mediated signaling pathway  glycosylphosphatidylinositol phospholipase D activity  glycosylphosphatidylinositol phospholipase D activity  phospholipase D activity  extracellular region  proteinaceous extracellular matrix  extracellular space  intracellular  cytoplasm  cytoplasm  lysosomal membrane  C-terminal protein lipidation  GPI anchor release  GPI anchor release  negative regulation of cell proliferation  insulin receptor signaling pathway  response to glucose  positive regulation of endothelial cell migration  positive regulation of alkaline phosphatase activity  positive regulation of triglyceride biosynthetic process  negative regulation of triglyceride catabolic process  positive regulation of glucose metabolic process  positive regulation of high-density lipoprotein particle clearance  sodium channel regulator activity  cellular response to insulin stimulus  cellular response to drug  hematopoietic stem cell migration  positive regulation of insulin secretion involved in cellular response to glucose stimulus  positive regulation of apoptotic process  intracellular membrane-bounded organelle  positive regulation of cytolysis  phosphatidylcholine metabolic process  phosphatidylcholine metabolic process  positive regulation of membrane protein ectodomain proteolysis  positive regulation of secretion  extracellular exosome  transepithelial transport  cellular response to calcium ion  cellular response to cholesterol  cellular response to triglyceride  cellular response to pH  hematopoietic stem cell migration to bone marrow  regulation of cellular response to insulin stimulus  
Ontology : EGO-EBIossification  cell migration involved in sprouting angiogenesis  chondrocyte differentiation  complement receptor mediated signaling pathway  glycosylphosphatidylinositol phospholipase D activity  glycosylphosphatidylinositol phospholipase D activity  phospholipase D activity  extracellular region  proteinaceous extracellular matrix  extracellular space  intracellular  cytoplasm  cytoplasm  lysosomal membrane  C-terminal protein lipidation  GPI anchor release  GPI anchor release  negative regulation of cell proliferation  insulin receptor signaling pathway  response to glucose  positive regulation of endothelial cell migration  positive regulation of alkaline phosphatase activity  positive regulation of triglyceride biosynthetic process  negative regulation of triglyceride catabolic process  positive regulation of glucose metabolic process  positive regulation of high-density lipoprotein particle clearance  sodium channel regulator activity  cellular response to insulin stimulus  cellular response to drug  hematopoietic stem cell migration  positive regulation of insulin secretion involved in cellular response to glucose stimulus  positive regulation of apoptotic process  intracellular membrane-bounded organelle  positive regulation of cytolysis  phosphatidylcholine metabolic process  phosphatidylcholine metabolic process  positive regulation of membrane protein ectodomain proteolysis  positive regulation of secretion  extracellular exosome  transepithelial transport  cellular response to calcium ion  cellular response to cholesterol  cellular response to triglyceride  cellular response to pH  hematopoietic stem cell migration to bone marrow  regulation of cellular response to insulin stimulus  
Pathways : BIOCARTAADP-Ribosylation Factor [Genes]   
Pathways : KEGGGlycosylphosphatidylinositol(GPI)-anchor biosynthesis   
NDEx NetworkGPLD1
Atlas of Cancer Signalling NetworkGPLD1
Wikipedia pathwaysGPLD1
Orthology - Evolution
OrthoDB2822
GeneTree (enSembl)ENSG00000112293
Phylogenetic Trees/Animal Genes : TreeFamGPLD1
HOVERGENP80108
HOGENOMP80108
Homologs : HomoloGeneGPLD1
Homology/Alignments : Family Browser (UCSC)GPLD1
Gene fusions - Rearrangements
Fusion : MitelmanGPLD1/TDP2 [6p22.3/6p22.3]  
Fusion PortalGPLD1 6p22.3 TDP2 6p22.3 GBM
Fusion : QuiverGPLD1
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerGPLD1 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)GPLD1
dbVarGPLD1
ClinVarGPLD1
1000_GenomesGPLD1 
Exome Variant ServerGPLD1
ExAC (Exome Aggregation Consortium)ENSG00000112293
GNOMAD BrowserENSG00000112293
Genetic variants : HAPMAP2822
Genomic Variants (DGV)GPLD1 [DGVbeta]
DECIPHERGPLD1 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisGPLD1 
Mutations
ICGC Data PortalGPLD1 
TCGA Data PortalGPLD1 
Broad Tumor PortalGPLD1
OASIS PortalGPLD1 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICGPLD1  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDGPLD1
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch GPLD1
DgiDB (Drug Gene Interaction Database)GPLD1
DoCM (Curated mutations)GPLD1 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)GPLD1 (select a term)
intoGenGPLD1
Cancer3DGPLD1(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM602515   
Orphanet
DisGeNETGPLD1
MedgenGPLD1
Genetic Testing Registry GPLD1
NextProtP80108 [Medical]
TSGene2822
GENETestsGPLD1
Target ValidationGPLD1
Huge Navigator GPLD1 [HugePedia]
snp3D : Map Gene to Disease2822
BioCentury BCIQGPLD1
ClinGenGPLD1
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD2822
Chemical/Pharm GKB GenePA28842
Clinical trialGPLD1
Miscellaneous
canSAR (ICR)GPLD1 (select the gene name)
Probes
Litterature
PubMed58 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineGPLD1
EVEXGPLD1
GoPubMedGPLD1
iHOPGPLD1
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Fri Jun 22 16:27:49 CEST 2018

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