GPLD1 (glycosylphosphatidylinositol specific phospholipase D1)

2003-05-01  

Identity

HGNC
LOCATION
6p22.3
LOCUSID
ALIAS
GPIPLD,GPIPLDM,PIGPLD,PIGPLD1,PLD
FUSION GENES

Other Information

Locus ID:

NCBI: 2822
MIM: 602515
HGNC: 4459
Ensembl: ENSG00000112293

Variants:

dbSNP: 2822
ClinVar: 2822
TCGA: ENSG00000112293
COSMIC: GPLD1

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000112293ENST00000230036P80108

Expression (GTEx)

0
5
10
15
20

Pathways

PathwaySourceExternal ID
Glycosylphosphatidylinositol (GPI)-anchor biosynthesisKEGGko00563
Glycosylphosphatidylinositol (GPI)-anchor biosynthesisKEGGhsa00563
Metabolism of proteinsREACTOMER-HSA-392499
Post-translational protein modificationREACTOMER-HSA-597592
Post-translational modification: synthesis of GPI-anchored proteinsREACTOMER-HSA-163125

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
189403122008Population-based genome-wide association studies reveal six loci influencing plasma levels of liver enzymes.150
206484722010PNPLA3 variants specifically confer increased risk for histologic nonalcoholic fatty liver disease but not metabolic disease.105
249909522014Phospholipase D and the maintenance of phosphatidic acid levels for regulation of mammalian target of rapamycin (mTOR).45
158147062005Exocytosis of CTLA-4 is dependent on phospholipase D and ADP ribosylation factor-1 and stimulated during activation of regulatory T cells.36
179498982007Phospholipase D provides a survival signal in human cancer cells with activated H-Ras or K-Ras.34
155009112004Characterization of primate trypanosome lytic factors.28
256329612015Reciprocal regulation of AMP-activated protein kinase and phospholipase D.22
249909482014Functional regulation of phospholipase D expression in cancer and inflammation.17
265679122016Down-regulation of MicroRNAs (MiRs) 203, 887, 3619 and 182 Prevents Vimentin-triggered, Phospholipase D (PLD)-mediated Cancer Cell Invasion.17
259645592015Down-regulation of Phospholipase D Stimulates Death of Lung Cancer Cells Involving Up-regulation of the Long ncRNA ANRIL.14

Citation

Dessen P

GPLD1 (glycosylphosphatidylinositol specific phospholipase D1)

Atlas Genet Cytogenet Oncol Haematol. 2003-05-01

Online version: http://atlasgeneticsoncology.org/gene/40738/gpld1