GPM6A (glycoprotein M6A)

2015-05-01 Affiliation

Identity

HGNC

GPM6A

LOCATION

4q34.2

LOCUSID

2823

ALIAS

GPM6,M6A

FUSION GENES

Show Gene Fusions

Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool

Other Information

Locus ID:

NCBI: 2823
MIM: 601275
HGNC: 4460
Ensembl: ENSG00000150625

Variants:

dbSNP: 2823
ClinVar: 2823
TCGA: ENSG00000150625
COSMIC: GPM6A

RNA/Proteins

Gene ID	Transcript ID	Uniprot
ENSG00000150625	ENST00000280187	P51674
ENSG00000150625	ENST00000393658	P51674
ENSG00000150625	ENST00000502754	D6REJ8
ENSG00000150625	ENST00000503397	D6R9D2
ENSG00000150625	ENST00000503563	A0A1D5RMS2
ENSG00000150625	ENST00000505304	D6RD71
ENSG00000150625	ENST00000505375	D6RBH3
ENSG00000150625	ENST00000505561	D6RD95
ENSG00000150625	ENST00000506894	P51674
ENSG00000150625	ENST00000507520	D6RBM6
ENSG00000150625	ENST00000507540	D6RFY0
ENSG00000150625	ENST00000509865	D6RAE4
ENSG00000150625	ENST00000512509	D6RB41
ENSG00000150625	ENST00000512610	D6RDV7
ENSG00000150625	ENST00000512897	D6RIF4
ENSG00000150625	ENST00000513365	D6R9T7
ENSG00000150625	ENST00000513667	D6RFZ3
ENSG00000150625	ENST00000515090	P51674

Expression (GTEx)

100

150

200

250

300

350

400

450

500

Adipose - Subcutaneous

Adipose - Visceral

Adrenal Gland

Artery - Aorta

Artery - Tibial

Bladder

Brain - Amygdala

Brain - Anterior cingulate cortex

Brain - Caudate

Brain - Cerebellar Hemisphere

Brain - Cerebellum

Brain - Cortex

Brain - Frontal Cortex

Brain - Hippocampus

Brain - Hypothalamus

Brain - Nucleus accumbens

Brain - Putamen

Brain - Spinal cord

Brain - Substantia nigra

Breast - Mammary Tissue

Cells - Cultured fibroblasts

Cells - EBV - transformed lymphocytes

Cervix - Ectocervix

Cervix - Endocervix

Colon - Sigmoid

Colon - Transverse

Esophagus - Gastroesophageal Junction

Esophagus - Mucosa

Esophagus - Muscularis

Fallopian Tube

Heart - Atrial Appendage

Heart - Left Ventricle

Kidney - Cortex

Kidney - Medulla

Liver

Lung

Minor Salivary Gland

Muscle - Skeletal

Nerve - Tibial

Ovary

Pancreas

Pituitary

Prostate

Skin - Not Sun Exposed

Skin - Sun Exposed

Small Intestine - Terminal Ileum

Spleen

Stomach

Testis

Thyroid

Uterus

Vagina

Whole Blood

Protein levels (Protein atlas)

Not detected

Low

Medium

High

References

Pubmed ID	Year	Title	Citations
20379614	2010	Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.	62
21041608	2011	Family-based analysis of genetic variation underlying psychosis-inducing effects of cannabis: sibling analysis and proband follow-up.	48
20400778	2010	Genomic variation associated with mortality among adults of European and African ancestry with heart failure: the cohorts for heart and aging research in genomic epidemiology consortium.	28
18163405	2008	Do mood symptoms subdivide the schizophrenia phenotype? Association of the GMP6A gene with a depression subgroup.	16
18163405	2008	Do mood symptoms subdivide the schizophrenia phenotype? Association of the GMP6A gene with a depression subgroup.	16
19298174	2009	Human GPM6A is associated with differentiation and neuronal migration of neurons derived from human embryonic stem cells.	13
28332716	2018	miR-124 and miR-9 mediated downregulation of HDAC5 promotes neurite development through activating MEF2C-GPM6A pathway.	12
18574501	2008	Membrane glycoprotein M6A promotes mu-opioid receptor endocytosis and facilitates receptor sorting into the recycling pathway.	10
25224183	2014	Altered GPM6A/M6 dosage impairs cognition and causes phenotypes responsive to cholesterol in human and Drosophila.	10
29573145	2018	Profiling of m6A RNA modifications identified an age-associated regulation of AGO2 mRNA stability.	8

Citation

Dessen P

GPM6A (glycoprotein M6A)

Atlas Genet Cytogenet Oncol Haematol. 2015-05-01

Online version: http://atlasgeneticsoncology.org/gene/55189/gpm6a