GPN3 (GPN-loop GTPase 3)

2016-10-01  

Identity

HGNC
GPN3
LOCATION
12q24.11
LOCUSID
51184
ALIAS
ATPBD1C
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 51184
HGNC: 30186
Ensembl: ENSG00000111231

Variants:

dbSNP: 51184
ClinVar: 51184
TCGA: ENSG00000111231
COSMIC: GPN3

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000111231ENST00000228827Q9UHW5
ENSG00000111231ENST00000537466Q9UHW5
ENSG00000111231ENST00000543199Q9UHW5
ENSG00000111231ENST00000549963S4R3M7
ENSG00000111231ENST00000550228H0YI19
ENSG00000111231ENST00000550974F8W1F4
ENSG00000111231ENST00000551079H0YHZ5

Expression (GTEx)

0
10
20
30
40
50
60
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
217683072011Human GTPases associate with RNA polymerase II to mediate its nuclear import.22
217828562011Parcs/Gpn3 is required for the nuclear accumulation of RNA polymerase II.10
252411682014Gpn1 and Gpn3 associate tightly and their protein levels are mutually dependent in mammalian cells.2
289401952017The Gpn3 Q279* cancer-associated mutant inhibits Gpn1 nuclear export and is deficient in RNA polymerase II nuclear targeting.0
290293782017Gpn3 is polyubiquitinated on lysine 216 and degraded by the proteasome in the cell nucleus in a Gpn1-inhibitable manner.0
314311352019Gpn3 Is Essential for Cell Proliferation of Breast Cancer Cells Independent of Their Malignancy Degree.0

Citation

Dessen P

GPN3 (GPN-loop GTPase 3)

Atlas Genet Cytogenet Oncol Haematol. 2016-10-01

Online version: http://atlasgeneticsoncology.org/gene/56200/gpn3