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GPR146 (G protein-coupled receptor 146)

Identity

Alias_symbol (synonym)PGR8
Other alias
HGNC (Hugo) GPR146
LocusID (NCBI) 115330
Atlas_Id 63963
Location 7p22.3  [Link to chromosome band 7p22]
Location_base_pair Starts at 1044573 and ends at 1059269 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)		Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
GPR146 (7p22.3) / DTNBP1 (6p22.3)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 

Other Solid tumors implicated (Data extracted from papers in the Atlas) [ 1 ]
  t(6;7)(p22;p22) GPR146/DTNBP1

External links

Nomenclature
HGNC (Hugo)GPR146   21718
Cards
Entrez_Gene (NCBI)GPR146  115330  G protein-coupled receptor 146
AliasesPGR8
GeneCards (Weizmann)GPR146
Ensembl hg19 (Hinxton)ENSG00000164849 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000164849 [Gene_View]  ENSG00000164849 [Sequence]  chr7:1044573-1059269 [Contig_View]  GPR146 [Vega]
ICGC DataPortalENSG00000164849
TCGA cBioPortalGPR146
AceView (NCBI)GPR146
Genatlas (Paris)GPR146
WikiGenes115330
SOURCE (Princeton)GPR146
Genetics Home Reference (NIH)GPR146
Genomic and cartography
GoldenPath hg38 (UCSC)GPR146  -     chr7:1044573-1059269 +  7p22.3   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)GPR146  -     7p22.3   [Description]    (hg19-Feb_2009)
EnsemblGPR146 - 7p22.3 [CytoView hg19]  GPR146 - 7p22.3 [CytoView hg38]
Mapping of homologs : NCBIGPR146 [Mapview hg19]  GPR146 [Mapview hg38]
Gene and transcription
Genbank (Entrez)AI813303 AK300166 AK313171 AY255535 BC014241
RefSeq transcript (Entrez)NM_001303473 NM_001303474 NM_138445
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)GPR146
Cluster EST : UnigeneHs.718624 [ NCBI ]
CGAP (NCI)Hs.718624
Alternative Splicing GalleryENSG00000164849
Gene ExpressionGPR146 [ NCBI-GEO ]   GPR146 [ EBI - ARRAY_EXPRESS ]   GPR146 [ SEEK ]   GPR146 [ MEM ]
Gene Expression Viewer (FireBrowse)GPR146 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevestigatorExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)115330
GTEX Portal (Tissue expression)GPR146
Human Protein AtlasENSG00000164849-GPR146 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ96CH1   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ96CH1  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ96CH1
Splice isoforms : SwissVarQ96CH1
PhosPhoSitePlusQ96CH1
Domaine pattern : Prosite (Expaxy)G_PROTEIN_RECEP_F1_2 (PS50262)   
Domains : Interpro (EBI)GPCR_Rhodpsn    GPCR_Rhodpsn_7TM   
Domain families : Pfam (Sanger)7tm_1 (PF00001)   
Domain families : Pfam (NCBI)pfam00001   
Conserved Domain (NCBI)GPR146
DMDM Disease mutations115330
Blocks (Seattle)GPR146
SuperfamilyQ96CH1
Human Protein Atlas [tissue]ENSG00000164849-GPR146 [tissue]
Peptide AtlasQ96CH1
HPRD17064
IPIIPI00060424   IPI01014478   IPI00892882   IPI00892549   
Protein Interaction databases
DIP (DOE-UCLA)Q96CH1
IntAct (EBI)Q96CH1
FunCoupENSG00000164849
BioGRIDGPR146
STRING (EMBL)GPR146
ZODIACGPR146
Ontologies - Pathways
QuickGOQ96CH1
Ontology : AmiGOG-protein coupled receptor activity  plasma membrane  G-protein coupled receptor signaling pathway  integral component of membrane  
Ontology : EGO-EBIG-protein coupled receptor activity  plasma membrane  G-protein coupled receptor signaling pathway  integral component of membrane  
NDEx NetworkGPR146
Atlas of Cancer Signalling NetworkGPR146
Wikipedia pathwaysGPR146
Orthology - Evolution
OrthoDB115330
GeneTree (enSembl)ENSG00000164849
Phylogenetic Trees/Animal Genes : TreeFamGPR146
HOVERGENQ96CH1
HOGENOMQ96CH1
Homologs : HomoloGeneGPR146
Homology/Alignments : Family Browser (UCSC)GPR146
Gene fusions - Rearrangements
Fusion : QuiverGPR146
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerGPR146 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)GPR146
dbVarGPR146
ClinVarGPR146
1000_GenomesGPR146 
Exome Variant ServerGPR146
ExAC (Exome Aggregation Consortium)ENSG00000164849
GNOMAD BrowserENSG00000164849
Varsome BrowserGPR146
Genetic variants : HAPMAP115330
Genomic Variants (DGV)GPR146 [DGVbeta]
DECIPHERGPR146 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisGPR146 
Mutations
ICGC Data PortalGPR146 
TCGA Data PortalGPR146 
Broad Tumor PortalGPR146
OASIS PortalGPR146 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICGPR146  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDGPR146
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch GPR146
DgiDB (Drug Gene Interaction Database)GPR146
DoCM (Curated mutations)GPR146 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)GPR146 (select a term)
intoGenGPR146
Cancer3DGPR146(select the gene name)
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM
Orphanet
DisGeNETGPR146
MedgenGPR146
Genetic Testing Registry GPR146
NextProtQ96CH1 [Medical]
TSGene115330
GENETestsGPR146
Target ValidationGPR146
Huge Navigator GPR146 [HugePedia]
snp3D : Map Gene to Disease115330
BioCentury BCIQGPR146
ClinGenGPR146
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD115330
Chemical/Pharm GKB GenePA134958088
Clinical trialGPR146
Miscellaneous
canSAR (ICR)GPR146 (select the gene name)
Probes
Litterature
PubMed7 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineGPR146
EVEXGPR146
GoPubMedGPR146
iHOPGPR146
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Mon Jul 30 13:47:48 CEST 2018
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