GPR161 (G protein-coupled receptor 161)

2014-06-01  

Identity

HGNC
LOCATION
1q24.2
LOCUSID
ALIAS
RE2
FUSION GENES

Other Information

Locus ID:

NCBI: 23432
MIM: 612250
HGNC: 23694
Ensembl: ENSG00000143147

Variants:

dbSNP: 23432
ClinVar: 23432
TCGA: ENSG00000143147
COSMIC: GPR161

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000143147ENST00000271357A0A0A0MQW8
ENSG00000143147ENST00000367835Q8N6U8
ENSG00000143147ENST00000367836Q8N6U8
ENSG00000143147ENST00000367838Q8N6U8
ENSG00000143147ENST00000537209Q8N6U8
ENSG00000143147ENST00000539777Q8N6U8
ENSG00000143147ENST00000546300Q8N6U8

Expression (GTEx)

0
5
10
15
20
25
30
35
40
45

Pathways

PathwaySourceExternal ID
Hedgehog signaling pathwayKEGGko04340
Hedgehog signaling pathwayKEGGhsa04340
Signal TransductionREACTOMER-HSA-162582
Signaling by HedgehogREACTOMER-HSA-5358351
Hedgehog 'off' stateREACTOMER-HSA-5610787
Hedgehog 'on' stateREACTOMER-HSA-5632684

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
270021702016Smoothened determines β-arrestin-mediated removal of the G protein-coupled receptor Gpr161 from the primary cilium.38
195361752009Follow-up of a major linkage peak on chromosome 1 reveals suggestive QTLs associated with essential hypertension: GenNet study.30
245995922014G-protein-coupled receptor GPR161 is overexpressed in breast cancer and is a promoter of cell proliferation and invasion.24
273576762016Gpr161 anchoring of PKA consolidates GPCR and cAMP signaling.22
190646102009Pre-B-cell leukemia homeobox 1 (PBX1) shows functional and possible genetic association with bone mineral density variation.16
293861062018Basal Suppression of the Sonic Hedgehog Pathway by the G-Protein-Coupled Receptor Gpr161 Restricts Medulloblastoma Pathogenesis.14
119591422002False positive non-synonymous polymorphisms of G-protein coupled receptor genes.5
302569842019Dominant negative GPR161 rare variants are risk factors of human spina bifida.3
316096492020Germline GPR161 Mutations Predispose to Pediatric Medulloblastoma.3
277319252017G-protein-coupled receptor signaling and neural tube closure defects.0

Citation

Dessen P

GPR161 (G protein-coupled receptor 161)

Atlas Genet Cytogenet Oncol Haematol. 2014-06-01

Online version: http://atlasgeneticsoncology.org/gene/53926/gpr161