GPR17 (G protein-coupled receptor 17)

2014-03-01 Affiliation

Identity

HGNC

GPR17

LOCATION

2q14.3

LOCUSID

2840

ALIAS

Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool

Other Information

Locus ID:

NCBI: 2840
MIM: 603071
HGNC: 4471
Ensembl: ENSG00000144230

Variants:

dbSNP: 2840
ClinVar: 2840
TCGA: ENSG00000144230
COSMIC: GPR17

RNA/Proteins

Gene ID	Transcript ID	Uniprot
ENSG00000144230	ENST00000272644	Q13304
ENSG00000144230	ENST00000393018	Q13304
ENSG00000144230	ENST00000423019	C9JWY5
ENSG00000144230	ENST00000544369	Q13304

Expression (GTEx)

Adipose - Subcutaneous

Adipose - Visceral

Adrenal Gland

Artery - Aorta

Artery - Tibial

Bladder

Brain - Amygdala

Brain - Anterior cingulate cortex

Brain - Caudate

Brain - Cerebellar Hemisphere

Brain - Cerebellum

Brain - Cortex

Brain - Frontal Cortex

Brain - Hippocampus

Brain - Hypothalamus

Brain - Nucleus accumbens

Brain - Putamen

Brain - Spinal cord

Brain - Substantia nigra

Breast - Mammary Tissue

Cells - Cultured fibroblasts

Cells - EBV - transformed lymphocytes

Cervix - Ectocervix

Cervix - Endocervix

Colon - Sigmoid

Colon - Transverse

Esophagus - Gastroesophageal Junction

Esophagus - Mucosa

Esophagus - Muscularis

Fallopian Tube

Heart - Atrial Appendage

Heart - Left Ventricle

Kidney - Cortex

Kidney - Medulla

Liver

Lung

Minor Salivary Gland

Muscle - Skeletal

Nerve - Tibial

Ovary

Pancreas

Pituitary

Prostate

Skin - Not Sun Exposed

Skin - Sun Exposed

Small Intestine - Terminal Ileum

Spleen

Stomach

Testis

Thyroid

Uterus

Vagina

Whole Blood

Pathways

Pathway	Source	External ID
Signal Transduction	REACTOME	R-HSA-162582
Signaling by GPCR	REACTOME	R-HSA-372790
GPCR ligand binding	REACTOME	R-HSA-500792
Class A/1 (Rhodopsin-like receptors)	REACTOME	R-HSA-373076
Eicosanoid ligand-binding receptors	REACTOME	R-HSA-391903
Leukotriene receptors	REACTOME	R-HSA-391906
Nucleotide-like (purinergic) receptors	REACTOME	R-HSA-418038
P2Y receptors	REACTOME	R-HSA-417957
GPCR downstream signaling	REACTOME	R-HSA-388396
G alpha (i) signalling events	REACTOME	R-HSA-418594
G alpha (q) signalling events	REACTOME	R-HSA-416476
Gastrin-CREB signalling pathway via PKC and MAPK	REACTOME	R-HSA-881907

Protein levels (Protein atlas)

Not detected

Low

Medium

High

References

Pubmed ID	Year	Title	Citations
16990797	2006	The orphan receptor GPR17 identified as a new dual uracil nucleotides/cysteinyl-leukotrienes receptor.	115
24150254	2013	Decoding signaling and function of the orphan G protein-coupled receptor GPR17 with a small-molecule agonist.	36
20148890	2010	Distinct expression and ligand-binding profiles of two constitutively active GPR17 splice variants.	28
18533035	2008	GPR17: molecular modeling and dynamics studies of the 3-D structure and purinergic ligand binding features in comparison with P2Y receptors.	16
23288840	2013	The regulated expression, intracellular trafficking, and membrane recycling of the P2Y-like receptor GPR17 in Oli-neu oligodendroglial cells.	16
21531793	2011	Agonist-induced desensitization/resensitization of human G protein-coupled receptor 17: a functional cross-talk between purinergic and cysteinyl-leukotriene ligands.	14
19625605	2009	Functional characterization of two isoforms of the P2Y-like receptor GPR17: [35S]GTPgammaS binding and electrophysiological studies in 1321N1 cells.	13
24613411	2014	Does GRK-β arrestin machinery work as a "switch on" for GPR17-mediated activation of intracellular signaling pathways?	9
25624481	2015	GPR17 gene disruption does not alter food intake or glucose homeostasis in mice.	5
28254957	2017	The Orphan Receptor GPR17 Is Unresponsive to Uracil Nucleotides and Cysteinyl Leukotrienes.	5

Citation

Dessen P

GPR17 (G protein-coupled receptor 17)

Atlas Genet Cytogenet Oncol Haematol. 2014-03-01

Online version: http://atlasgeneticsoncology.org/gene/53846/gpr17