GPR35 (G protein-coupled receptor 35)

2017-10-01  

Identity

HGNC
GPR35
LOCATION
2q37.3
LOCUSID
2859
ALIAS
-
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 2859
MIM: 602646
HGNC: 4492
Ensembl: ENSG00000178623

Variants:

dbSNP: 2859
ClinVar: 2859
TCGA: ENSG00000178623
COSMIC: GPR35

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000178623ENST00000319838Q9HC97
ENSG00000178623ENST00000403859Q9HC97
ENSG00000178623ENST00000407714Q9HC97
ENSG00000178623ENST00000430267Q9HC97
ENSG00000178623ENST00000438013Q9HC97

Expression (GTEx)

0
5
10
15
20
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Neuroactive ligand-receptor interactionKEGGko04080
Neuroactive ligand-receptor interactionKEGGhsa04080
Signal TransductionREACTOMER-HSA-162582
Signaling by GPCRREACTOMER-HSA-372790
GPCR ligand bindingREACTOMER-HSA-500792
Class A/1 (Rhodopsin-like receptors)REACTOMER-HSA-373076

References

Pubmed IDYearTitleCitations
203619372010GPR35 is a novel lysophosphatidic acid receptor.47
209199922010Identification of novel species-selective agonists of the G-protein-coupled receptor GPR35 that promote recruitment of β-arrestin-2 and activate Gα13.39
228214032013Genome-wide association analysis in primary sclerosing cholangitis and ulcerative colitis identifies risk loci at GPR35 and TCF4.37
254112032015Cutting edge: GPR35/CXCR8 is the receptor of the mucosal chemokine CXCL17.34
205997112010Expression of functional GPR35 in human iNKT cells.23
179401992008Inhibition of N-type calcium channels by activation of GPR35, an orphan receptor, heterologously expressed in rat sympathetic neurons.21
182710572008Application of machine learning algorithms to predict coronary artery calcification with a sibship-based design.21
254899602015Immunochip analysis identification of 6 additional susceptibility loci for Crohn's disease in Koreans.19
228201672013GPR55 and GPR35 and their relationship to cannabinoid and lysophospholipid receptors.16
289434342017The role and clinical significance of the CXCL17-CXCR8 (GPR35) axis in breast cancer.10

Citation

Dessen P

GPR35 (G protein-coupled receptor 35)

Atlas Genet Cytogenet Oncol Haematol. 2017-10-01

Online version: http://atlasgeneticsoncology.org/gene/57101/gpr35