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GPR39 (G protein-coupled receptor 39)

Identity

Other alias-
HGNC (Hugo) GPR39
LocusID (NCBI) 2863
Atlas_Id 47434
Location 2q21.2  [Link to chromosome band 2q21]
Location_base_pair Starts at 132416574 and ends at 132646596 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2016)
GPR39 (2q21.2) / MGAT5 (2q21.2)GPR39 (2q21.2) / ZNF112 (19q13.31)GPR39 (2q21.2) / ZNF285 (19q13.31)
HNRNPDL (4q21.22) / GPR39 (2q21.2)IGSF1 (Xq26.2) / GPR39 (2q21.2)MGAT5 (2q21.2) / GPR39 (2q21.2)
GPR39 2q21.2 / ZNF285 19q13.31

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


Other Solid tumors implicated (Data extracted from papers in the Atlas) [ 1 ]
  Lung: Translocations in Squamous Cell Carcinoma


External links

Nomenclature
HGNC (Hugo)GPR39   4496
Cards
Entrez_Gene (NCBI)GPR39  2863  G protein-coupled receptor 39
Aliases
GeneCards (Weizmann)GPR39
Ensembl hg19 (Hinxton)ENSG00000183840 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000183840 [Gene_View]  chr2:132416574-132646596 [Contig_View]  GPR39 [Vega]
ICGC DataPortalENSG00000183840
TCGA cBioPortalGPR39
AceView (NCBI)GPR39
Genatlas (Paris)GPR39
WikiGenes2863
SOURCE (Princeton)GPR39
Genetics Home Reference (NIH)GPR39
Genomic and cartography
GoldenPath hg38 (UCSC)GPR39  -     chr2:132416574-132646596 +  2q21.2   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)GPR39  -     2q21.2   [Description]    (hg19-Feb_2009)
EnsemblGPR39 - 2q21.2 [CytoView hg19]  GPR39 - 2q21.2 [CytoView hg38]
Mapping of homologs : NCBIGPR39 [Mapview hg19]  GPR39 [Mapview hg38]
OMIM602886   
Gene and transcription
Genbank (Entrez)AF034633 AI459805 AK122643 AK123759 AK314895
RefSeq transcript (Entrez)NM_001508
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)GPR39
Cluster EST : UnigeneHs.744392 [ NCBI ]
CGAP (NCI)Hs.744392
Alternative Splicing GalleryENSG00000183840
Gene ExpressionGPR39 [ NCBI-GEO ]   GPR39 [ EBI - ARRAY_EXPRESS ]   GPR39 [ SEEK ]   GPR39 [ MEM ]
Gene Expression Viewer (FireBrowse)GPR39 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)2863
GTEX Portal (Tissue expression)GPR39
Protein : pattern, domain, 3D structure
UniProt/SwissProtO43194   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtO43194  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProO43194
Splice isoforms : SwissVarO43194
PhosPhoSitePlusO43194
Domaine pattern : Prosite (Expaxy)G_PROTEIN_RECEP_F1_1 (PS00237)    G_PROTEIN_RECEP_F1_2 (PS50262)   
Domains : Interpro (EBI)GPCR_Rhodpsn    GPCR_Rhodpsn_7TM   
Domain families : Pfam (Sanger)7tm_1 (PF00001)   
Domain families : Pfam (NCBI)pfam00001   
Conserved Domain (NCBI)GPR39
DMDM Disease mutations2863
Blocks (Seattle)GPR39
SuperfamilyO43194
Human Protein AtlasENSG00000183840
Peptide AtlasO43194
HPRD04198
IPIIPI00011241   
Protein Interaction databases
DIP (DOE-UCLA)O43194
IntAct (EBI)O43194
FunCoupENSG00000183840
BioGRIDGPR39
STRING (EMBL)GPR39
ZODIACGPR39
Ontologies - Pathways
QuickGOO43194
Ontology : AmiGOG-protein coupled receptor activity  plasma membrane  integral component of plasma membrane  G-protein coupled receptor signaling pathway  metal ion binding  
Ontology : EGO-EBIG-protein coupled receptor activity  plasma membrane  integral component of plasma membrane  G-protein coupled receptor signaling pathway  metal ion binding  
NDEx NetworkGPR39
Atlas of Cancer Signalling NetworkGPR39
Wikipedia pathwaysGPR39
Orthology - Evolution
OrthoDB2863
GeneTree (enSembl)ENSG00000183840
Phylogenetic Trees/Animal Genes : TreeFamGPR39
HOVERGENO43194
HOGENOMO43194
Homologs : HomoloGeneGPR39
Homology/Alignments : Family Browser (UCSC)GPR39
Gene fusions - Rearrangements
Fusion : MitelmanGPR39/MGAT5 [2q21.2/2q21.2]  
Fusion : MitelmanGPR39/ZNF285 [2q21.2/19q13.31]  [t(2;19)(q21;q13)]  
Fusion : MitelmanMGAT5/GPR39 [2q21.2/2q21.2]  [t(2;2)(q21;q21)]  
Fusion: TCGAGPR39 2q21.2 ZNF285 19q13.31 LUAD
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerGPR39 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)GPR39
dbVarGPR39
ClinVarGPR39
1000_GenomesGPR39 
Exome Variant ServerGPR39
ExAC (Exome Aggregation Consortium)GPR39 (select the gene name)
Genetic variants : HAPMAP2863
Genomic Variants (DGV)GPR39 [DGVbeta]
DECIPHERGPR39 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisGPR39 
Mutations
ICGC Data PortalGPR39 
TCGA Data PortalGPR39 
Broad Tumor PortalGPR39
OASIS PortalGPR39 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICGPR39  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDGPR39
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch GPR39
DgiDB (Drug Gene Interaction Database)GPR39
DoCM (Curated mutations)GPR39 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)GPR39 (select a term)
intoGenGPR39
Cancer3DGPR39(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM602886   
Orphanet
MedgenGPR39
Genetic Testing Registry GPR39
NextProtO43194 [Medical]
TSGene2863
GENETestsGPR39
Target ValidationGPR39
Huge Navigator GPR39 [HugePedia]
snp3D : Map Gene to Disease2863
BioCentury BCIQGPR39
ClinGenGPR39
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD2863
Chemical/Pharm GKB GenePA28885
Clinical trialGPR39
Miscellaneous
canSAR (ICR)GPR39 (select the gene name)
Probes
Litterature
PubMed37 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineGPR39
EVEXGPR39
GoPubMedGPR39
iHOPGPR39
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Tue Aug 1 17:02:24 CEST 2017

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