GPR4 (G protein-coupled receptor 4)

2007-02-01  

Identity

HGNC
GPR4
LOCATION
19q13.32
LOCUSID
2828
ALIAS
GPR6C.l

Other Information

Locus ID:

NCBI: 2828
MIM: 600551
HGNC: 4497
Ensembl: ENSG00000177464

Variants:

dbSNP: 2828
ClinVar: 2828
TCGA: ENSG00000177464
COSMIC: GPR4

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000177464ENST00000323040P46093

Expression (GTEx)

0
10
20
30
40
50
60
70
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Signal TransductionREACTOMER-HSA-162582
Signaling by GPCRREACTOMER-HSA-372790
GPCR ligand bindingREACTOMER-HSA-500792
Class A/1 (Rhodopsin-like receptors)REACTOMER-HSA-373076
GPCR downstream signalingREACTOMER-HSA-388396
G alpha (q) signalling eventsREACTOMER-HSA-416476
Gastrin-CREB signalling pathway via PKC and MAPKREACTOMER-HSA-881907

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
129551482003Proton-sensing G-protein-coupled receptors.182
221106802011Activation of GPR4 by acidosis increases endothelial cell adhesion through the cAMP/Epac pathway.41
164614262006Lysophosphatidylcholine impairs endothelial barrier function through the G protein-coupled receptor GPR4.29
174628612007Previously postulated "ligand-independent" signaling of GPR4 is mediated through proton-sensing mechanisms.25
152210072004G protein-coupled receptors GPR4 and TDAG8 are oncogenic and overexpressed in human cancers.23
202117292010Each one of certain histidine residues in G-protein-coupled receptor GPR4 is critical for extracellular proton-induced stimulation of multiple G-protein-signaling pathways.21
158578922005GPR4 plays a critical role in endothelial cell function and mediates the effects of sphingosylphosphorylcholine.18
281348102017Acidosis Activates Endoplasmic Reticulum Stress Pathways through GPR4 in Human Vascular Endothelial Cells.18
128050232003Inflammatory stress increases receptor for lysophosphatidylcholine in human microvascular endothelial cells.16
145676792003The G protein-coupled receptor GPR4 suppresses ERK activation in a ligand-independent manner.13

Citation

Dessen P

GPR4 (G protein-coupled receptor 4)

Atlas Genet Cytogenet Oncol Haematol. 2007-02-01

Online version: http://atlasgeneticsoncology.org/gene/45722/gpr4