GPR50 (G protein-coupled receptor 50)

2019-04-01 Affiliation

Identity

HGNC

GPR50

LOCATION

Xq28

LOCUSID

9248

ALIAS

H9,Mel1c

Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool

Other Information

Locus ID:

NCBI: 9248
MIM: 300207
HGNC: 4506
Ensembl: ENSG00000102195

Variants:

dbSNP: 9248
ClinVar: 9248
TCGA: ENSG00000102195
COSMIC: GPR50

RNA/Proteins

Gene ID	Transcript ID	Uniprot
ENSG00000102195	ENST00000218316	Q13585

Expression (GTEx)

Adipose - Subcutaneous

Adipose - Visceral

Adrenal Gland

Artery - Aorta

Artery - Tibial

Bladder

Brain - Amygdala

Brain - Anterior cingulate cortex

Brain - Caudate

Brain - Cerebellar Hemisphere

Brain - Cerebellum

Brain - Cortex

Brain - Frontal Cortex

Brain - Hippocampus

Brain - Hypothalamus

Brain - Nucleus accumbens

Brain - Putamen

Brain - Spinal cord

Brain - Substantia nigra

Breast - Mammary Tissue

Cells - Cultured fibroblasts

Cells - EBV - transformed lymphocytes

Cervix - Ectocervix

Cervix - Endocervix

Colon - Sigmoid

Colon - Transverse

Esophagus - Gastroesophageal Junction

Esophagus - Mucosa

Esophagus - Muscularis

Fallopian Tube

Heart - Atrial Appendage

Heart - Left Ventricle

Kidney - Cortex

Kidney - Medulla

Liver

Lung

Minor Salivary Gland

Muscle - Skeletal

Nerve - Tibial

Ovary

Pancreas

Pituitary

Prostate

Skin - Not Sun Exposed

Skin - Sun Exposed

Small Intestine - Terminal Ileum

Spleen

Stomach

Testis

Thyroid

Uterus

Vagina

Whole Blood

Pathways

Pathway	Source	External ID
Neuroactive ligand-receptor interaction	KEGG	ko04080
Neuroactive ligand-receptor interaction	KEGG	hsa04080

Protein levels (Protein atlas)

Not detected

Low

Medium

High

cerebral cortex

cerebellum

hippocampus

caudate

thyroid gland

parathyroid gland

adrenal gland

pituitary gland

nasopharynx

bronchus

lung

oral mucosa

salivary gland

esophagus

stomach 1

stomach 2

duodenum

small intestine

colon

rectum

liver

gallbladder

pancreas

kidney

urinary bladder

testis

epididymis

seminal vesicle

prostate

vagina

ovary

fallopian tube

endometrium 1

endometrium 2

cervix, uterine

placenta

breast

heart muscle

smooth muscle

skeletal muscle

soft tissue 1

soft tissue 2

adipose tissue

skin 1

skin 2

appendix

spleen

lymph node

tonsil

bone marrow

References

Pubmed ID	Year	Title	Citations
20351714	2011	Poor replication of candidate genes for major depressive disorder using genome-wide association data.	92
16778767	2006	The orphan GPR50 receptor specifically inhibits MT1 melatonin receptor function through heterodimerization.	90
20377855	2010	Mutation screening of melatonin-related genes in patients with autism spectrum disorders.	33
15452587	2005	Sex-specific association between bipolar affective disorder in women and GPR50, an X-linked orphan G protein-coupled receptor.	31
15452587	2005	Sex-specific association between bipolar affective disorder in women and GPR50, an X-linked orphan G protein-coupled receptor.	31
20657642	2010	Identification of pathway-biased and deleterious melatonin receptor mutants in autism spectrum disorders and in the general population.	21
19699797	2009	GPR50 interacts with neuronal NOGO-A and affects neurite outgrowth.	19
20210849	2010	Expression of the orphan GPR50 protein in rodent and human dorsomedial hypothalamus, tanycytes and median eminence.	16
16436372	2006	Sequence variants in the melatonin-related receptor gene (GPR50) associate with circulating triglyceride and HDL levels.	13
16436372	2006	Sequence variants in the melatonin-related receptor gene (GPR50) associate with circulating triglyceride and HDL levels.	13

Citation

Dessen P

GPR50 (G protein-coupled receptor 50)

Atlas Genet Cytogenet Oncol Haematol. 2019-04-01

Online version: http://atlasgeneticsoncology.org/gene/57933/gpr50