GPRC6A (G protein-coupled receptor class C group 6 member A)

2012-03-01  

Identity

HGNC
LOCATION
6q22.1
LOCUSID
ALIAS
GPCR,bA86F4.3

Other Information

Locus ID:

NCBI: 222545
MIM: 613572
HGNC: 18510
Ensembl: ENSG00000173612

Variants:

dbSNP: 222545
ClinVar: 222545
TCGA: ENSG00000173612
COSMIC: GPRC6A

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000173612ENST00000310357Q5T6X5
ENSG00000173612ENST00000368549Q5T6X5
ENSG00000173612ENST00000530250Q5T6X5

Expression (GTEx)

0
1

Pathways

PathwaySourceExternal ID
NOD-like receptor signaling pathwayKEGGko04621
NOD-like receptor signaling pathwayKEGGhsa04621
Signal TransductionREACTOMER-HSA-162582
Signaling by GPCRREACTOMER-HSA-372790
GPCR ligand bindingREACTOMER-HSA-500792
Class C/3 (Metabotropic glutamate/pheromone receptors)REACTOMER-HSA-420499
GPCR downstream signalingREACTOMER-HSA-388396
G alpha (q) signalling eventsREACTOMER-HSA-416476
Gastrin-CREB signalling pathway via PKC and MAPKREACTOMER-HSA-881907

References

Pubmed IDYearTitleCitations
206760982010Genome-wide association study identifies five new susceptibility loci for prostate cancer in the Japanese population.124
232716612012Extracellular Ca2+ is a danger signal activating the NLRP3 inflammasome through G protein-coupled calcium sensing receptors.94
161995322005Identification of a novel extracellular cation-sensing G-protein-coupled receptor.79
155766282005Deorphanization of GPRC6A: a promiscuous L-alpha-amino acid receptor with preference for basic amino acids.59
237281772013Osteocalcin regulates murine and human fertility through a pancreas-bone-testis axis.59
151941882004Molecular cloning, expression, and sequence analysis of GPRC6A, a novel family C G-protein-coupled receptor.53
232696702013The G protein-coupled receptor family C group 6 subtype A (GPRC6A) receptor is involved in amino acid-induced glucagon-like peptide-1 secretion from GLUTag cells.37
216817792012GPRC6A regulates prostate cancer progression.30
198742002010Impaired osteoblast function in GPRC6A null mice.25
226622422012Replication and fine mapping for association of the C2orf43, FOXP4, GPRC6A and RFX6 genes with prostate cancer in the Chinese population.16

Citation

Dessen P

GPRC6A (G protein-coupled receptor class C group 6 member A)

Atlas Genet Cytogenet Oncol Haematol. 2012-03-01

Online version: http://atlasgeneticsoncology.org/gene/52630/gprc6a