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GPS2 (G protein pathway suppressor 2)

Identity

Other aliasAMF-1
HGNC (Hugo) GPS2
LocusID (NCBI) 2874
Atlas_Id 53670
Location 17p13.1  [Link to chromosome band 17p13]
Location_base_pair Starts at 7215978 and ends at 7218658 bp from pter ( according to hg19-Feb_2009)
Fusion genes
(updated 2016)
GPS2 (17p13.1) / MPP2 (17q21.31)KMT2B (19q13.12) / GPS2 (17p13.1)SENP3 (17p13.1) / GPS2 (17p13.1)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


Other Leukemias implicated (Data extracted from papers in the Atlas) [ 1 ]
  del(13q) in chronic lymphocytic leukemia


External links

Nomenclature
HGNC (Hugo)GPS2   4550
Cards
Entrez_Gene (NCBI)GPS2  2874  G protein pathway suppressor 2
AliasesAMF-1
GeneCards (Weizmann)GPS2
Ensembl hg19 (Hinxton)ENSG00000132522 [Gene_View]  chr17:7215978-7218658 [Contig_View]  GPS2 [Vega]
Ensembl hg38 (Hinxton)ENSG00000132522 [Gene_View]  chr17:7215978-7218658 [Contig_View]  GPS2 [Vega]
ICGC DataPortalENSG00000132522
TCGA cBioPortalGPS2
AceView (NCBI)GPS2
Genatlas (Paris)GPS2
WikiGenes2874
SOURCE (Princeton)GPS2
Genetics Home Reference (NIH)GPS2
Genomic and cartography
GoldenPath hg19 (UCSC)GPS2  -     chr17:7215978-7218658 -  17p13.1   [Description]    (hg19-Feb_2009)
GoldenPath hg38 (UCSC)GPS2  -     17p13.1   [Description]    (hg38-Dec_2013)
EnsemblGPS2 - 17p13.1 [CytoView hg19]  GPS2 - 17p13.1 [CytoView hg38]
Mapping of homologs : NCBIGPS2 [Mapview hg19]  GPS2 [Mapview hg38]
OMIM601935   
Gene and transcription
Genbank (Entrez)AK301877 BC013652 BC014192 BC103901 BC103902
RefSeq transcript (Entrez)NM_004489
RefSeq genomic (Entrez)NC_000017 NC_018928 NT_010718 NW_004929405
Consensus coding sequences : CCDS (NCBI)GPS2
Cluster EST : UnigeneHs.438219 [ NCBI ]
CGAP (NCI)Hs.438219
Alternative Splicing GalleryENSG00000132522
Gene ExpressionGPS2 [ NCBI-GEO ]   GPS2 [ EBI - ARRAY_EXPRESS ]   GPS2 [ SEEK ]   GPS2 [ MEM ]
Gene Expression Viewer (FireBrowse)GPS2 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)2874
GTEX Portal (Tissue expression)GPS2
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ13227   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ13227  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ13227
Splice isoforms : SwissVarQ13227
PhosPhoSitePlusQ13227
Domains : Interpro (EBI)GPS2   
Domain families : Pfam (Sanger)G_path_suppress (PF15991)   
Domain families : Pfam (NCBI)pfam15991   
Conserved Domain (NCBI)GPS2
DMDM Disease mutations2874
Blocks (Seattle)GPS2
PDB (SRS)2L5G   
PDB (PDBSum)2L5G   
PDB (IMB)2L5G   
PDB (RSDB)2L5G   
Structural Biology KnowledgeBase2L5G   
SCOP (Structural Classification of Proteins)2L5G   
CATH (Classification of proteins structures)2L5G   
SuperfamilyQ13227
Human Protein AtlasENSG00000132522
Peptide AtlasQ13227
HPRD11878
IPIIPI00012301   IPI01014698   IPI00929474   
Protein Interaction databases
DIP (DOE-UCLA)Q13227
IntAct (EBI)Q13227
FunCoupENSG00000132522
BioGRIDGPS2
STRING (EMBL)GPS2
ZODIACGPS2
Ontologies - Pathways
QuickGOQ13227
Ontology : AmiGOnegative regulation of transcription from RNA polymerase II promoter  inactivation of MAPK activity  transcription corepressor activity  GTPase inhibitor activity  protein binding  nucleoplasm  cell cycle  JNK cascade  transcriptional repressor complex  negative regulation of GTPase activity  negative regulation of JNK cascade  
Ontology : EGO-EBInegative regulation of transcription from RNA polymerase II promoter  inactivation of MAPK activity  transcription corepressor activity  GTPase inhibitor activity  protein binding  nucleoplasm  cell cycle  JNK cascade  transcriptional repressor complex  negative regulation of GTPase activity  negative regulation of JNK cascade  
Pathways : KEGGHTLV-I infection   
NDEx NetworkGPS2
Atlas of Cancer Signalling NetworkGPS2
Wikipedia pathwaysGPS2
Orthology - Evolution
OrthoDB2874
GeneTree (enSembl)ENSG00000132522
Phylogenetic Trees/Animal Genes : TreeFamGPS2
HOVERGENQ13227
HOGENOMQ13227
Homologs : HomoloGeneGPS2
Homology/Alignments : Family Browser (UCSC)GPS2
Gene fusions - Rearrangements
Fusion : MitelmanGPS2/MPP2 [17p13.1/17q21.31]  
Fusion : MitelmanKMT2B/GPS2 [19q13.12/17p13.1]  [t(17;19)(p13;q13)]  
Fusion : MitelmanSENP3/GPS2 [17p13.1/17p13.1]  [t(17;17)(p13;p13)]  
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerGPS2 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)GPS2
dbVarGPS2
ClinVarGPS2
1000_GenomesGPS2 
Exome Variant ServerGPS2
ExAC (Exome Aggregation Consortium)GPS2 (select the gene name)
Genetic variants : HAPMAP2874
Genomic Variants (DGV)GPS2 [DGVbeta]
DECIPHER (Syndromes)17:7215978-7218658  ENSG00000132522
CONAN: Copy Number AnalysisGPS2 
Mutations
ICGC Data PortalGPS2 
TCGA Data PortalGPS2 
Broad Tumor PortalGPS2
OASIS PortalGPS2 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICGPS2  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDGPS2
intOGen PortalGPS2
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch GPS2
DgiDB (Drug Gene Interaction Database)GPS2
DoCM (Curated mutations)GPS2 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)GPS2 (select a term)
intoGenGPS2
Cancer3DGPS2(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM601935   
Orphanet
MedgenGPS2
Genetic Testing Registry GPS2
NextProtQ13227 [Medical]
TSGene2874
GENETestsGPS2
Huge Navigator GPS2 [HugePedia]
snp3D : Map Gene to Disease2874
BioCentury BCIQGPS2
ClinGenGPS2
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD2874
Chemical/Pharm GKB GenePA28945
Clinical trialGPS2
Miscellaneous
canSAR (ICR)GPS2 (select the gene name)
Probes
Litterature
PubMed47 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineGPS2
EVEXGPS2
GoPubMedGPS2
iHOPGPS2
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Thu Mar 30 15:02:57 CEST 2017

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