GPSM1 (G protein signaling modulator 1)

2003-12-01  

Identity

HGNC
GPSM1
LOCATION
9q34.3
LOCUSID
26086
ALIAS
AGS3
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 26086
MIM: 609491
HGNC: 17858
Ensembl: ENSG00000160360

Variants:

dbSNP: 26086
ClinVar: 26086
TCGA: ENSG00000160360
COSMIC: GPSM1

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000160360ENST00000291775Q86YR5
ENSG00000160360ENST00000354753A0A0A0MRC4
ENSG00000160360ENST00000392944Q86YR5
ENSG00000160360ENST00000429455Q86YR5
ENSG00000160360ENST00000440944A0A0A0MSK4
ENSG00000160360ENST00000616132A0A087WVF5

Expression (GTEx)

0
50
100
150
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Cocaine addictionKEGGhsa05030
Cocaine addictionKEGGko05030
Signal TransductionREACTOMER-HSA-162582
Signaling by GPCRREACTOMER-HSA-372790
GPCR downstream signalingREACTOMER-HSA-388396
G alpha (i) signalling eventsREACTOMER-HSA-418594

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
212093162011A GDI (AGS3) and a GEF (GIV) regulate autophagy by balancing G protein activity and growth factor signals.55
239453952014Genome-wide association study identifies three novel loci for type 2 diabetes.52
109690642000Stabilization of the GDP-bound conformation of Gialpha by a peptide derived from the G-protein regulatory motif of AGS3.46
126425772003The G-protein regulator AGS3 controls an early event during macroautophagy in human intestinal HT-29 cells.32
202374962010New genetic associations detected in a host response study to hepatitis B vaccine.27
207165242010Regulation of the AGS3·G{alpha}i signaling complex by a seven-transmembrane span receptor.26
179917702007A specific role of AGS3 in the surface expression of plasma membrane proteins.22
185664502008The PDZ and band 4.1 containing protein Frmpd1 regulates the subcellular location of activator of G-protein signaling 3 and its interaction with G-proteins.22
129257522003Subcellular localization of LGN during mitosis: evidence for its cortical localization in mitotic cell culture systems and its requirement for normal cell cycle progression.20
200650322010Distribution of activator of G-protein signaling 3 within the aggresomal pathway: role of specific residues in the tetratricopeptide repeat domain and differential regulation by the AGS3 binding partners Gi(alpha) and mammalian inscuteable.16

Citation

Dessen P

GPSM1 (G protein signaling modulator 1)

Atlas Genet Cytogenet Oncol Haematol. 2003-12-01

Online version: http://atlasgeneticsoncology.org/gene/40746/gpsm1