Atlas of Genetics and Cytogenetics in Oncology and Haematology

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GPT (glutamic--pyruvic transaminase)

Identity

Alias (NCBI)AAT1
ALT1
GPT1
HGNC (Hugo) GPT
HGNC Alias symbALT1
GPT1
HGNC Alias namealanine aminotransferase
 alanine transaminase
HGNC Previous nameglutamic-pyruvate transaminase (alanine aminotransferase)
LocusID (NCBI) 2875
Atlas_Id 49867
Location 8q24.3  [Link to chromosome band 8q24]
Location_base_pair Starts at 144504140 and ends at 144507172 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)		Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 

Other Solid tumors implicated (Data extracted from papers in the Atlas) [ 1 ]
  Liver: Fibrolamellar carcinoma

External links

Nomenclature
HGNC (Hugo)GPT   4552
Cards
Entrez_Gene (NCBI)GPT    glutamic--pyruvic transaminase
AliasesAAT1; ALT1; GPT1
GeneCards (Weizmann)GPT
Ensembl hg19 (Hinxton)ENSG00000167701 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000167701 [Gene_View]  ENSG00000167701 [Sequence]  chr8:144504140-144507172 [Contig_View]  GPT [Vega]
ICGC DataPortalENSG00000167701
TCGA cBioPortalGPT
AceView (NCBI)GPT
Genatlas (Paris)GPT
SOURCE (Princeton)GPT
Genetics Home Reference (NIH)GPT
Genomic and cartography
GoldenPath hg38 (UCSC)GPT  -     chr8:144504140-144507172 +  8q24.3   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)GPT  -     8q24.3   [Description]    (hg19-Feb_2009)
GoldenPathGPT - 8q24.3 [CytoView hg19]  GPT - 8q24.3 [CytoView hg38]
ImmunoBaseENSG00000167701
genome Data Viewer NCBIGPT [Mapview hg19]  
OMIM138200   
Gene and transcription
Genbank (Entrez)AI283141 AK225562 AK298488 AK303779 BC018207
RefSeq transcript (Entrez)NM_001382664 NM_001382665 NM_005309
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)GPT
Alternative Splicing GalleryENSG00000167701
Gene ExpressionGPT [ NCBI-GEO ]   GPT [ EBI - ARRAY_EXPRESS ]   GPT [ SEEK ]   GPT [ MEM ]
Gene Expression Viewer (FireBrowse)GPT [ Firebrowse - Broad ]
GenevisibleExpression of GPT in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)2875
GTEX Portal (Tissue expression)GPT
Human Protein AtlasENSG00000167701-GPT [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtP24298   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtP24298  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProP24298
Splice isoforms : SwissVarP24298
Catalytic activity : Enzyme2.6.1.2 [ Enzyme-Expasy ]   2.6.1.22.6.1.2 [ IntEnz-EBI ]   2.6.1.2 [ BRENDA ]   2.6.1.2 [ KEGG ]   [ MEROPS ]
PhosPhoSitePlusP24298
Domains : Interpro (EBI)Aminotransferase_I/II    PyrdxlP-dep_Trfase    PyrdxlP-dep_Trfase_dom1    PyrdxlP-dep_Trfase_major   
Domain families : Pfam (Sanger)Aminotran_1_2 (PF00155)   
Domain families : Pfam (NCBI)pfam00155   
Conserved Domain (NCBI)GPT
Blocks (Seattle)GPT
SuperfamilyP24298
Human Protein Atlas [tissue]ENSG00000167701-GPT [tissue]
Peptide AtlasP24298
HPRD00689
IPIIPI00217458   IPI00909969   
Protein Interaction databases
DIP (DOE-UCLA)P24298
IntAct (EBI)P24298
BioGRIDGPT
STRING (EMBL)GPT
ZODIACGPT
Ontologies - Pathways
QuickGOP24298
Ontology : AmiGOL-alanine:2-oxoglutarate aminotransferase activity  cytosol  cellular amino acid biosynthetic process  pyridoxal phosphate binding  cellular response to insulin stimulus  response to starvation  L-alanine catabolic process  positive regulation of gluconeogenesis  extracellular exosome  
Ontology : EGO-EBIL-alanine:2-oxoglutarate aminotransferase activity  cytosol  cellular amino acid biosynthetic process  pyridoxal phosphate binding  cellular response to insulin stimulus  response to starvation  L-alanine catabolic process  positive regulation of gluconeogenesis  extracellular exosome  
Pathways : KEGGAlanine, aspartate and glutamate metabolism   
NDEx NetworkGPT
Atlas of Cancer Signalling NetworkGPT
Wikipedia pathwaysGPT
Orthology - Evolution
OrthoDB2875
GeneTree (enSembl)ENSG00000167701
Phylogenetic Trees/Animal Genes : TreeFamGPT
HOGENOMP24298
Homologs : HomoloGeneGPT
Homology/Alignments : Family Browser (UCSC)GPT
Gene fusions - Rearrangements
Fusion : QuiverGPT
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerGPT [hg38]
dbVarGPT
ClinVarGPT
MonarchGPT
1000_GenomesGPT 
Exome Variant ServerGPT
GNOMAD BrowserENSG00000167701
Varsome BrowserGPT
Genomic Variants (DGV)GPT [DGVbeta]
DECIPHERGPT [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisGPT 
Mutations
ICGC Data PortalGPT 
TCGA Data PortalGPT 
Broad Tumor PortalGPT
OASIS PortalGPT [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICGPT  [overview]  [genome browser]  [tissue]  [distribution]  
Somatic Mutations in Cancer : COSMIC3DGPT
Mutations and Diseases : HGMDGPT
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch GPT
DgiDB (Drug Gene Interaction Database)GPT
DoCM (Curated mutations)GPT (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)GPT (select a term)
intoGenGPT
Cancer3DGPT(select the gene name)
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM138200   
Orphanet
DisGeNETGPT
MedgenGPT
Genetic Testing Registry GPT
NextProtP24298 [Medical]
GENETestsGPT
Target ValidationGPT
Huge Navigator GPT [HugePedia]
ClinGenGPT
Clinical trials, drugs, therapy
MyCancerGenomeGPT
Protein Interactions : CTD
Pharm GKB GenePA28947
PharosP24298
Clinical trialGPT
Miscellaneous
canSAR (ICR)GPT (select the gene name)
HarmonizomeGPT
DataMed IndexGPT
Probes
Litterature
PubMed135 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
EVEXGPT
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Fri Jan 1 18:17:43 CET 2021
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