GPT (glutamic--pyruvic transaminase)

2007-12-01 Affiliation

Identity

HGNC

GPT

LOCATION

8q24.3

LOCUSID

2875

ALIAS

AAT1,ALT1,GPT1

Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool

Other Information

Locus ID:

NCBI: 2875
MIM: 138200
HGNC: 4552
Ensembl: ENSG00000167701

Variants:

dbSNP: 2875
ClinVar: 2875
TCGA: ENSG00000167701
COSMIC: GPT

RNA/Proteins

Gene ID	Transcript ID	Uniprot
ENSG00000167701	ENST00000394955	P24298
ENSG00000167701	ENST00000528431	P24298

Expression (GTEx)

100

150

Adipose - Subcutaneous

Adipose - Visceral

Adrenal Gland

Artery - Aorta

Artery - Tibial

Bladder

Brain - Amygdala

Brain - Anterior cingulate cortex

Brain - Caudate

Brain - Cerebellar Hemisphere

Brain - Cerebellum

Brain - Cortex

Brain - Frontal Cortex

Brain - Hippocampus

Brain - Hypothalamus

Brain - Nucleus accumbens

Brain - Putamen

Brain - Spinal cord

Brain - Substantia nigra

Breast - Mammary Tissue

Cells - Cultured fibroblasts

Cells - EBV - transformed lymphocytes

Cervix - Ectocervix

Cervix - Endocervix

Colon - Sigmoid

Colon - Transverse

Esophagus - Gastroesophageal Junction

Esophagus - Mucosa

Esophagus - Muscularis

Fallopian Tube

Heart - Atrial Appendage

Heart - Left Ventricle

Kidney - Cortex

Kidney - Medulla

Liver

Lung

Minor Salivary Gland

Muscle - Skeletal

Nerve - Tibial

Ovary

Pancreas

Pituitary

Prostate

Skin - Not Sun Exposed

Skin - Sun Exposed

Small Intestine - Terminal Ileum

Spleen

Stomach

Testis

Thyroid

Uterus

Vagina

Whole Blood

Pathways

Pathway	Source	External ID
Arginine biosynthesis	KEGG	ko00220
Arginine biosynthesis	KEGG	hsa00220
Alanine, aspartate and glutamate metabolism	KEGG	ko00250
Alanine, aspartate and glutamate metabolism	KEGG	hsa00250
Metabolic pathways	KEGG	hsa01100
2-Oxocarboxylic acid metabolism	KEGG	hsa01210
2-Oxocarboxylic acid metabolism	KEGG	ko01210
Biosynthesis of amino acids	KEGG	hsa01230
Biosynthesis of amino acids	KEGG	ko01230
Carbon metabolism	KEGG	hsa01200
Carbon metabolism	KEGG	ko01200
Metabolism	REACTOME	R-HSA-1430728
Metabolism of amino acids and derivatives	REACTOME	R-HSA-71291
Amino acid synthesis and interconversion (transamination)	REACTOME	R-HSA-70614

Protein levels (Protein atlas)

Not detected

Low

Medium

High

References

Pubmed ID	Year	Title	Citations
12774006	2003	Clinical and histologic spectrum of nonalcoholic fatty liver disease associated with normal ALT values.	232
19100265	2009	Elevated serum alanine aminotransferase and gamma-glutamyltransferase and mortality in the United States population.	96
25145475	2015	The role of liver fat and insulin resistance as determinants of plasma aminotransferase elevation in nonalcoholic fatty liver disease.	40
18473412	2008	Persistent alanine aminotransferase elevation among the general Iranian population: prevalence and causes.	37
17934148	2008	Liver fat is increased in type 2 diabetic patients and underestimated by serum alanine aminotransferase compared with equally obese nondiabetic subjects.	33
22140488	2011	The association of PNPLA3 variants with liver enzymes in childhood obesity is driven by the interaction with abdominal fat.	31
19159884	2009	Elevated alanine aminotransferase levels predict mortality from cardiovascular disease and diabetes in Koreans.	30
21987480	2012	Upper limits of normal for alanine aminotransferase activity in the United States population.	29
18763311	2008	Relationship between alanine aminotransferase levels and metabolic syndrome in nonalcoholic fatty liver disease.	28
18090161	2007	Liver enzymes and histology in obese patients with obstructive sleep apnea.	26

Citation

Dessen P

GPT (glutamic--pyruvic transaminase)

Atlas Genet Cytogenet Oncol Haematol. 2007-12-01

Online version: http://atlasgeneticsoncology.org/gene/49867/gpt