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GPT2 (glutamic--pyruvic transaminase 2)

Identity

Alias_namesglutamic pyruvate transaminase 2
Alias_symbol (synonym)ALT2
Other aliasGPT 2
MRT49
HGNC (Hugo) GPT2
LocusID (NCBI) 84706
Atlas_Id 64023
Location 16q11.2  [Link to chromosome band 16q11]
Location_base_pair Starts at 46885114 and ends at 46931297 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
GPT2 (16q11.2) / HSD17B2 (16q23.3)GPT2 (16q11.2) / SH3BGRL (Xq21.1)ST5 (11p15.4) / GPT2 (16q11.2)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)GPT2   18062
Cards
Entrez_Gene (NCBI)GPT2  84706  glutamic--pyruvic transaminase 2
AliasesALT2; GPT; MRT49
GeneCards (Weizmann)GPT2
Ensembl hg19 (Hinxton)ENSG00000166123 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000166123 [Gene_View]  chr16:46885114-46931297 [Contig_View]  GPT2 [Vega]
ICGC DataPortalENSG00000166123
TCGA cBioPortalGPT2
AceView (NCBI)GPT2
Genatlas (Paris)GPT2
WikiGenes84706
SOURCE (Princeton)GPT2
Genetics Home Reference (NIH)GPT2
Genomic and cartography
GoldenPath hg38 (UCSC)GPT2  -     chr16:46885114-46931297 +  16q11.2   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)GPT2  -     16q11.2   [Description]    (hg19-Feb_2009)
EnsemblGPT2 - 16q11.2 [CytoView hg19]  GPT2 - 16q11.2 [CytoView hg38]
Mapping of homologs : NCBIGPT2 [Mapview hg19]  GPT2 [Mapview hg38]
OMIM138210   616281   
Gene and transcription
Genbank (Entrez)AI990701 AK090957 AK094971 AL833351 AY029173
RefSeq transcript (Entrez)NM_001142466 NM_133443
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)GPT2
Cluster EST : UnigeneHs.460693 [ NCBI ]
CGAP (NCI)Hs.460693
Alternative Splicing GalleryENSG00000166123
Gene ExpressionGPT2 [ NCBI-GEO ]   GPT2 [ EBI - ARRAY_EXPRESS ]   GPT2 [ SEEK ]   GPT2 [ MEM ]
Gene Expression Viewer (FireBrowse)GPT2 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevestigatorExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)84706
GTEX Portal (Tissue expression)GPT2
Human Protein AtlasENSG00000166123-GPT2 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ8TD30   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ8TD30  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ8TD30
Splice isoforms : SwissVarQ8TD30
Catalytic activity : Enzyme2.6.1.2 [ Enzyme-Expasy ]   2.6.1.22.6.1.2 [ IntEnz-EBI ]   2.6.1.2 [ BRENDA ]   2.6.1.2 [ KEGG ]   
PhosPhoSitePlusQ8TD30
Domains : Interpro (EBI)Aminotransferase_I/II    PyrdxlP-dep_Trfase    PyrdxlP-dep_Trfase_major_sub1    PyrdxlP-dep_Trfase_major_sub2   
Domain families : Pfam (Sanger)Aminotran_1_2 (PF00155)   
Domain families : Pfam (NCBI)pfam00155   
Conserved Domain (NCBI)GPT2
DMDM Disease mutations84706
Blocks (Seattle)GPT2
PDB (SRS)3IHJ   
PDB (PDBSum)3IHJ   
PDB (IMB)3IHJ   
PDB (RSDB)3IHJ   
Structural Biology KnowledgeBase3IHJ   
SCOP (Structural Classification of Proteins)3IHJ   
CATH (Classification of proteins structures)3IHJ   
SuperfamilyQ8TD30
Human Protein Atlas [tissue]ENSG00000166123-GPT2 [tissue]
Peptide AtlasQ8TD30
HPRD06307
IPIIPI00152432   IPI00784445   
Protein Interaction databases
DIP (DOE-UCLA)Q8TD30
IntAct (EBI)Q8TD30
FunCoupENSG00000166123
BioGRIDGPT2
STRING (EMBL)GPT2
ZODIACGPT2
Ontologies - Pathways
QuickGOQ8TD30
Ontology : AmiGOL-alanine:2-oxoglutarate aminotransferase activity  L-alanine:2-oxoglutarate aminotransferase activity  mitochondrial matrix  2-oxoglutarate metabolic process  cellular amino acid biosynthetic process  pyridoxal phosphate binding  L-alanine metabolic process  L-alanine catabolic process  
Ontology : EGO-EBIL-alanine:2-oxoglutarate aminotransferase activity  L-alanine:2-oxoglutarate aminotransferase activity  mitochondrial matrix  2-oxoglutarate metabolic process  cellular amino acid biosynthetic process  pyridoxal phosphate binding  L-alanine metabolic process  L-alanine catabolic process  
Pathways : KEGGAlanine, aspartate and glutamate metabolism   
NDEx NetworkGPT2
Atlas of Cancer Signalling NetworkGPT2
Wikipedia pathwaysGPT2
Orthology - Evolution
OrthoDB84706
GeneTree (enSembl)ENSG00000166123
Phylogenetic Trees/Animal Genes : TreeFamGPT2
HOVERGENQ8TD30
HOGENOMQ8TD30
Homologs : HomoloGeneGPT2
Homology/Alignments : Family Browser (UCSC)GPT2
Gene fusions - Rearrangements
Fusion: Tumor Portal GPT2
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerGPT2 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)GPT2
dbVarGPT2
ClinVarGPT2
1000_GenomesGPT2 
Exome Variant ServerGPT2
ExAC (Exome Aggregation Consortium)ENSG00000166123
GNOMAD BrowserENSG00000166123
Genetic variants : HAPMAP84706
Genomic Variants (DGV)GPT2 [DGVbeta]
DECIPHERGPT2 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisGPT2 
Mutations
ICGC Data PortalGPT2 
TCGA Data PortalGPT2 
Broad Tumor PortalGPT2
OASIS PortalGPT2 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICGPT2  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDGPT2
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
LOVD (Leiden Open Variation Database)MSeqDR-LSDB Mitochondrial Disease Locus Specific Database
BioMutasearch GPT2
DgiDB (Drug Gene Interaction Database)GPT2
DoCM (Curated mutations)GPT2 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)GPT2 (select a term)
intoGenGPT2
Cancer3DGPT2(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM138210    616281   
Orphanet
MedgenGPT2
Genetic Testing Registry GPT2
NextProtQ8TD30 [Medical]
TSGene84706
GENETestsGPT2
Target ValidationGPT2
Huge Navigator GPT2 [HugePedia]
snp3D : Map Gene to Disease84706
BioCentury BCIQGPT2
ClinGenGPT2
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD84706
Chemical/Pharm GKB GenePA28948
Clinical trialGPT2
Miscellaneous
canSAR (ICR)GPT2 (select the gene name)
Probes
Litterature
PubMed18 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineGPT2
EVEXGPT2
GoPubMedGPT2
iHOPGPT2
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Thu Nov 9 11:49:41 CET 2017

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