GPX2 (glutathione peroxidase 2)

2007-02-01 Affiliation

Identity

HGNC

GPX2

LOCATION

14q23.3

LOCUSID

2877

ALIAS

GI-GPx,GPRP,GPRP-2,GPx-2,GPx-GI,GSHPX-GI,GSHPx-2

Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool

Other Information

Locus ID:

NCBI: 2877
MIM: 138319
HGNC: 4554
Ensembl: ENSG00000176153

Variants:

dbSNP: 2877
ClinVar: 2877
TCGA: ENSG00000176153
COSMIC: GPX2

RNA/Proteins

Gene ID	Transcript ID	Uniprot
ENSG00000176153	ENST00000389614	P18283
ENSG00000176153	ENST00000553522	G3V323
ENSG00000176153	ENST00000557049	H0YJK8
ENSG00000176153	ENST00000557323	G3V4J6
ENSG00000176153	ENST00000612794	A0A087WTS0

Expression (GTEx)

100

150

200

250

Adipose - Subcutaneous

Adipose - Visceral

Adrenal Gland

Artery - Aorta

Artery - Tibial

Bladder

Brain - Amygdala

Brain - Anterior cingulate cortex

Brain - Caudate

Brain - Cerebellar Hemisphere

Brain - Cerebellum

Brain - Cortex

Brain - Frontal Cortex

Brain - Hippocampus

Brain - Hypothalamus

Brain - Nucleus accumbens

Brain - Putamen

Brain - Spinal cord

Brain - Substantia nigra

Breast - Mammary Tissue

Cells - Cultured fibroblasts

Cells - EBV - transformed lymphocytes

Cervix - Ectocervix

Cervix - Endocervix

Colon - Sigmoid

Colon - Transverse

Esophagus - Gastroesophageal Junction

Esophagus - Mucosa

Esophagus - Muscularis

Fallopian Tube

Heart - Atrial Appendage

Heart - Left Ventricle

Kidney - Cortex

Kidney - Medulla

Liver

Lung

Minor Salivary Gland

Muscle - Skeletal

Nerve - Tibial

Ovary

Pancreas

Pituitary

Prostate

Skin - Not Sun Exposed

Skin - Sun Exposed

Small Intestine - Terminal Ileum

Spleen

Stomach

Testis

Thyroid

Uterus

Vagina

Whole Blood

Pathways

Pathway	Source	External ID
Glutathione metabolism	KEGG	ko00480
Arachidonic acid metabolism	KEGG	ko00590
Glutathione metabolism	KEGG	hsa00480
Arachidonic acid metabolism	KEGG	hsa00590
Thyroid hormone synthesis	KEGG	hsa04918
Thyroid hormone synthesis	KEGG	ko04918
Gene Expression	REACTOME	R-HSA-74160
Generic Transcription Pathway	REACTOME	R-HSA-212436
Transcriptional Regulation by TP53	REACTOME	R-HSA-3700989
TP53 Regulates Metabolic Genes	REACTOME	R-HSA-5628897
Metabolism	REACTOME	R-HSA-1430728
Metabolism of lipids and lipoproteins	REACTOME	R-HSA-556833
Arachidonic acid metabolism	REACTOME	R-HSA-2142753
Synthesis of 5-eicosatetraenoic acids	REACTOME	R-HSA-2142688
Synthesis of 15-eicosatetraenoic acid derivatives	REACTOME	R-HSA-2142770
Synthesis of 12-eicosatetraenoic acid derivatives	REACTOME	R-HSA-2142712
Cellular responses to stress	REACTOME	R-HSA-2262752
Detoxification of Reactive Oxygen Species	REACTOME	R-HSA-3299685

Protein levels (Protein atlas)

Not detected

Low

Medium

High

References

Pubmed ID	Year	Title	Citations
19913121	2009	Gene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip.	85
15923610	2005	The GI-GPx gene is a target for Nrf2.	74
16794261	2006	Glutathione peroxidase 2, the major cigarette smoke-inducible isoform of GPX in lungs, is regulated by Nrf2.	74
16446369	2006	GPX2, a direct target of p63, inhibits oxidative stress-induced apoptosis in a p53-dependent manner.	50
18483336	2008	Variation in the selenoenzyme genes and risk of advanced distal colorectal adenoma.	41
18483336	2008	Variation in the selenoenzyme genes and risk of advanced distal colorectal adenoma.	41
18676680	2008	Pathway-based evaluation of 380 candidate genes and lung cancer susceptibility suggests the importance of the cell cycle pathway.	32
19692168	2010	Genetic susceptibility to distinct bladder cancer subphenotypes.	25
11811519	2001	Cellular and subcellular localization of gastrointestinal glutathione peroxidase in normal and malignant human intestinal tissue.	23
17277236	2007	A population-based association study of SNPs of GSTP1, MnSOD, GPX2 and Barrett's esophagus and esophageal adenocarcinoma.	22

Citation

Dessen P

GPX2 (glutathione peroxidase 2)

Atlas Genet Cytogenet Oncol Haematol. 2007-02-01

Online version: http://atlasgeneticsoncology.org/gene/45718/gpx2