Atlas of Genetics and Cytogenetics in Oncology and Haematology


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GPX2 (glutathione peroxidase 2)

Identity

Other namesGI-GPx
GPRP
GPRP-2
GPx-2
GPx-GI
GSHPX-GI
GSHPx-2
HGNC (Hugo) GPX2
LocusID (NCBI) 2877
Atlas_Id 45718
Location 14q23.3
Location_base_pair Starts at 65405870 and ends at 65409623 bp from pter ( according to hg19-Feb_2009)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 

External links

Nomenclature
HGNC (Hugo)GPX2   4554
Cards
Entrez_Gene (NCBI)GPX2  2877  glutathione peroxidase 2
GeneCards (Weizmann)GPX2
Ensembl hg19 (Hinxton)ENSG00000176153 [Gene_View]  chr14:65405870-65409623 [Contig_View]  GPX2 [Vega]
Ensembl hg38 (Hinxton)ENSG00000176153 [Gene_View]  chr14:65405870-65409623 [Contig_View]  GPX2 [Vega]
ICGC DataPortalENSG00000176153
TCGA cBioPortalGPX2
AceView (NCBI)GPX2
Genatlas (Paris)GPX2
WikiGenes2877
SOURCE (Princeton)GPX2
Genomic and cartography
GoldenPath hg19 (UCSC)GPX2  -     chr14:65405870-65409623 -  14q23.3   [Description]    (hg19-Feb_2009)
GoldenPath hg38 (UCSC)GPX2  -     14q23.3   [Description]    (hg38-Dec_2013)
EnsemblGPX2 - 14q23.3 [CytoView hg19]  GPX2 - 14q23.3 [CytoView hg38]
Mapping of homologs : NCBIGPX2 [Mapview hg19]  GPX2 [Mapview hg38]
OMIM138319   
Gene and transcription
Genbank (Entrez)AK225871 BC005277 BC016756 BC022820 BC039850
RefSeq transcript (Entrez)NM_002083
RefSeq genomic (Entrez)NC_000014 NC_018925 NT_026437 NW_004929393
Consensus coding sequences : CCDS (NCBI)GPX2
Cluster EST : UnigeneHs.2704 [ NCBI ]
CGAP (NCI)Hs.2704
Alternative Splicing : Fast-db (Paris)GSHG0009426
Alternative Splicing GalleryENSG00000176153
Gene ExpressionGPX2 [ NCBI-GEO ]     GPX2 [ SEEK ]   GPX2 [ MEM ]
SOURCE (Princeton)Expression in : [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
Protein : pattern, domain, 3D structure
UniProt/SwissProtP18283 (Uniprot)
NextProtP18283  [Medical]  [Publications]
With graphics : InterProP18283
Splice isoforms : SwissVarP18283 (Swissvar)
Catalytic activity : Enzyme1.11.1.9 [ Enzyme-Expasy ]   1.11.1.91.11.1.9 [ IntEnz-EBI ]   1.11.1.9 [ BRENDA ]   1.11.1.9 [ KEGG ]   
Domaine pattern : Prosite (Expaxy)GLUTATHIONE_PEROXID_1 (PS00460)    GLUTATHIONE_PEROXID_2 (PS00763)    GLUTATHIONE_PEROXID_3 (PS51355)   
Domains : Interpro (EBI)Glutathione_peroxidase    GPX_AS    GPX_CS    Thioredoxin-like_fold   
Related proteins : CluSTrP18283
Domain families : Pfam (Sanger)GSHPx (PF00255)   
Domain families : Pfam (NCBI)pfam00255   
DMDM Disease mutations2877
Blocks (Seattle)P18283
PDB (SRS)2HE3   
PDB (PDBSum)2HE3   
PDB (IMB)2HE3   
PDB (RSDB)2HE3   
Human Protein AtlasENSG00000176153
Peptide AtlasP18283
HPRD11818
IPIIPI00298176   IPI01024786   IPI01025107   IPI01025563   
Protein Interaction databases
DIP (DOE-UCLA)P18283
IntAct (EBI)P18283
FunCoupENSG00000176153
BioGRIDGPX2
IntegromeDBGPX2
STRING (EMBL)GPX2
Ontologies - Pathways
QuickGOP18283
Ontology : AmiGOresponse to reactive oxygen species  temperature homeostasis  negative regulation of inflammatory response to antigenic stimulus  glutathione peroxidase activity  cytoplasm  cytosol  electron carrier activity  response to symbiotic bacterium  interaction with symbiont  oxidation-reduction process  extracellular exosome  
Ontology : EGO-EBIresponse to reactive oxygen species  temperature homeostasis  negative regulation of inflammatory response to antigenic stimulus  glutathione peroxidase activity  cytoplasm  cytosol  electron carrier activity  response to symbiotic bacterium  interaction with symbiont  oxidation-reduction process  extracellular exosome  
Pathways : KEGGGlutathione metabolism    Arachidonic acid metabolism    Thyroid hormone synthesis   
Protein Interaction DatabaseGPX2
DoCM (Curated mutations)GPX2
Wikipedia pathwaysGPX2
Gene fusion - Rearrangements
Gene fusion: TCGA
Polymorphisms : SNP, variants
NCBI Variation ViewerGPX2 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)GPX2
dbVarGPX2
ClinVarGPX2
1000_GenomesGPX2 
Exome Variant ServerGPX2
SNP (GeneSNP Utah)GPX2
SNP : HGBaseGPX2
Genetic variants : HAPMAPGPX2
Genomic Variants (DGV)GPX2 [DGVbeta]
Mutations
ICGC Data PortalGPX2 
TCGA Data PortalGPX2 
Tumor PortalGPX2
Somatic Mutations in Cancer : COSMICGPX2 
LOVD (Leiden Open Variation Database)genes/GPX2
LOVD (Leiden Open Variation Database)genes/GPX2
LOVD (Leiden Open Variation Database)genes/GPX2
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] 
Diseases
DECIPHER (Syndromes)14:65405870-65409623
CONAN: Copy Number AnalysisGPX2 
Mutations and Diseases : HGMDGPX2
OMIM138319   
MedgenGPX2
NextProtP18283 [Medical]
GENETestsGPX2
Disease Genetic AssociationGPX2
Huge Navigator GPX2 [HugePedia]  GPX2 [HugeCancerGEM]
snp3D : Map Gene to Disease2877
DGIdb (Drug Gene Interaction db)GPX2
BioCentury BCIQGPX2
General knowledge
Homologs : HomoloGeneGPX2
Homology/Alignments : Family Browser (UCSC)GPX2
Phylogenetic Trees/Animal Genes : TreeFamGPX2
Chemical/Protein Interactions : CTD2877
Chemical/Pharm GKB GenePA28950
Clinical trialGPX2
Cancer Resource (Charite)ENSG00000176153
Other databases
Probes
Litterature
PubMed44 Pubmed reference(s) in Entrez
CoreMineGPX2
GoPubMedGPX2
iHOPGPX2
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

Search in all EBI   NCBI

Contributor(s)

Written09-2002Dessen P, Le Minor S
Updated02-2015Dessen P

© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Fri May 29 18:35:43 CEST 2015

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