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Taking over the Atlas
Dear Colleagues,
The Atlas, once more, is in great danger, and I will have to proceed to a collective economic lay-off of all the team involved in the Atlas before the begining of April 2015 (a foundation having suddenly withdrawn its commitment to support the Atlas). I ask you herein if any Scientific Society (a Society of Cytogenetics, of Clinical Genetics, of Hematology, or a Cancer Society, or any other...), any University and/or Hospital, any Charity, or any database would be interested in taking over the Atlas, in whole or in part. If taking charge of the whole lot is too big, a consortium of various actors could be the solution (I am myself trying to find partners). Could you please spread the information, contact the relevant authorities, and find partners.
Survival of the Atlas will be critically dependant upon your ability to find solutions (and urgently!).
Kind regards.
Jean-Loup Huret
Donations are also welcome

Donate (in Euros)

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GPX2 (glutathione peroxidase 2 (gastrointestinal))

Identity

Other namesGI-GPx
GPRP
GPRP-2
GPx-2
GPx-GI
GSHPX-GI
GSHPx-2
HGNC (Hugo) GPX2
LocusID (NCBI) 2877
Location 14q23.3
Location_base_pair Starts at 65405870 and ends at 65409623 bp from pter ( according to hg19-Feb_2009)
Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 

External links

Nomenclature
HGNC (Hugo)GPX2   4554
Cards
Entrez_Gene (NCBI)GPX2  2877  glutathione peroxidase 2 (gastrointestinal)
GeneCards (Weizmann)GPX2
Ensembl hg19 (Hinxton)ENSG00000176153 [Gene_View]  chr14:65405870-65409623 [Contig_View]  GPX2 [Vega]
Ensembl hg38 (Hinxton)ENSG00000176153 [Gene_View]  chr14:65405870-65409623 [Contig_View]  GPX2 [Vega]
ICGC DataPortalENSG00000176153
cBioPortalGPX2
AceView (NCBI)GPX2
Genatlas (Paris)GPX2
WikiGenes2877
SOURCE (Princeton)GPX2
Genomic and cartography
GoldenPath hg19 (UCSC)GPX2  -     chr14:65405870-65409623 -  14q23.3   [Description]    (hg19-Feb_2009)
GoldenPath hg38 (UCSC)GPX2  -     14q23.3   [Description]    (hg38-Dec_2013)
EnsemblGPX2 - 14q23.3 [CytoView hg19]  GPX2 - 14q23.3 [CytoView hg38]
Mapping of homologs : NCBIGPX2 [Mapview hg19]  GPX2 [Mapview hg38]
OMIM138319   
Gene and transcription
Genbank (Entrez)AK225871 BC005277 BC016756 BC022820 BC039850
RefSeq transcript (Entrez)NM_002083
RefSeq genomic (Entrez)AC_000146 NC_000014 NC_018925 NT_026437 NW_001838111 NW_004929393
Consensus coding sequences : CCDS (NCBI)GPX2
Cluster EST : UnigeneHs.2704 [ NCBI ]
CGAP (NCI)Hs.2704
Alternative Splicing : Fast-db (Paris)GSHG0009426
Alternative Splicing GalleryENSG00000176153
Gene ExpressionGPX2 [ NCBI-GEO ]     GPX2 [ SEEK ]   GPX2 [ MEM ]
SOURCE (Princeton)Expression in : [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
Protein : pattern, domain, 3D structure
UniProt/SwissProtP18283 (Uniprot)
NextProtP18283  [Medical]
With graphics : InterProP18283
Splice isoforms : SwissVarP18283 (Swissvar)
Catalytic activity : Enzyme1.11.1.9 [ Enzyme-Expasy ]   1.11.1.91.11.1.9 [ IntEnz-EBI ]   1.11.1.9 [ BRENDA ]   1.11.1.9 [ KEGG ]   
Domaine pattern : Prosite (Expaxy)GLUTATHIONE_PEROXID_1 (PS00460)    GLUTATHIONE_PEROXID_2 (PS00763)    GLUTATHIONE_PEROXID_3 (PS51355)   
Domains : Interpro (EBI)Glutathione_peroxidase    Thioredoxin-like_fold   
Related proteins : CluSTrP18283
Domain families : Pfam (Sanger)GSHPx (PF00255)   
Domain families : Pfam (NCBI)pfam00255   
DMDM Disease mutations2877
Blocks (Seattle)P18283
PDB (SRS)2HE3   
PDB (PDBSum)2HE3   
PDB (IMB)2HE3   
PDB (RSDB)2HE3   
Human Protein AtlasENSG00000176153
Peptide AtlasP18283
HPRD11818
IPIIPI00298176   IPI01024786   IPI01025107   IPI01025563   
Protein Interaction databases
DIP (DOE-UCLA)P18283
IntAct (EBI)P18283
FunCoupENSG00000176153
BioGRIDGPX2
IntegromeDBGPX2
STRING (EMBL)GPX2
Ontologies - Pathways
QuickGOP18283
Ontology : AmiGOtemperature homeostasis  negative regulation of inflammatory response to antigenic stimulus  glutathione peroxidase activity  cytoplasm  cytosol  response to oxidative stress  electron carrier activity  response to symbiotic bacterium  interaction with symbiont  oxidation-reduction process  extracellular vesicular exosome  
Ontology : EGO-EBItemperature homeostasis  negative regulation of inflammatory response to antigenic stimulus  glutathione peroxidase activity  cytoplasm  cytosol  response to oxidative stress  electron carrier activity  response to symbiotic bacterium  interaction with symbiont  oxidation-reduction process  extracellular vesicular exosome  
Pathways : KEGGGlutathione metabolism    Arachidonic acid metabolism    Thyroid hormone synthesis   
Protein Interaction DatabaseGPX2
DoCM (Curated mutations)GPX2
Wikipedia pathwaysGPX2
Gene fusion - rearrangements
Polymorphisms : SNP, variants
NCBI Variation ViewerGPX2 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)GPX2
dbVarGPX2
ClinVarGPX2
1000_GenomesGPX2 
Exome Variant ServerGPX2
SNP (GeneSNP Utah)GPX2
SNP : HGBaseGPX2
Genetic variants : HAPMAPGPX2
Genomic Variants (DGV)GPX2 [DGVbeta]
Mutations
ICGC Data PortalENSG00000176153 
Somatic Mutations in Cancer : COSMICGPX2 
CONAN: Copy Number AnalysisGPX2 
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] 
Diseases
DECIPHER (Syndromes)14:65405870-65409623
Mutations and Diseases : HGMDGPX2
OMIM138319   
MedgenGPX2
NextProtP18283 [Medical]
GENETestsGPX2
Disease Genetic AssociationGPX2
Huge Navigator GPX2 [HugePedia]  GPX2 [HugeCancerGEM]
snp3D : Map Gene to Disease2877
DGIdb (Drug Gene Interaction db)GPX2
General knowledge
Homologs : HomoloGeneGPX2
Homology/Alignments : Family Browser (UCSC)GPX2
Phylogenetic Trees/Animal Genes : TreeFamGPX2
Chemical/Protein Interactions : CTD2877
Chemical/Pharm GKB GenePA28950
Clinical trialGPX2
Cancer Resource (Charite)ENSG00000176153
Other databases
Probes
Litterature
PubMed41 Pubmed reference(s) in Entrez
CoreMineGPX2
GoPubMedGPX2
iHOPGPX2
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

Search in all EBI   NCBI

Contributor(s)

Written09-2002Dessen P, Le Minor S
Updated12-2014Dessen P

© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Sat Feb 14 16:05:24 CET 2015

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