Atlas of Genetics and Cytogenetics in Oncology and Haematology


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GPX5 (glutathione peroxidase 5)

Identity

Other aliasHEL-S-75p
HGNC (Hugo) GPX5
LocusID (NCBI) 2880
Atlas_Id 40748
Location 6p22.1  [Link to chromosome band 6p22]
Location_base_pair Starts at 28526012 and ends at 28534951 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
XRCC6 (22q13.2) / GPX5 (6p22.1)XRCC6 22q13.2 / GPX5 6p22.1

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


Other Solid tumors implicated (Data extracted from papers in the Atlas) [ 1 ]
  t(6;22)(p22;q13) XRCC6/GPX5


External links

Nomenclature
HGNC (Hugo)GPX5   4557
Cards
Entrez_Gene (NCBI)GPX5  2880  glutathione peroxidase 5
AliasesHEL-S-75p
GeneCards (Weizmann)GPX5
Ensembl hg19 (Hinxton)ENSG00000224586 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000224586 [Gene_View]  ENSG00000224586 [Sequence]  chr6:28526012-28534951 [Contig_View]  GPX5 [Vega]
ICGC DataPortalENSG00000224586
TCGA cBioPortalGPX5
AceView (NCBI)GPX5
Genatlas (Paris)GPX5
WikiGenes2880
SOURCE (Princeton)GPX5
Genetics Home Reference (NIH)GPX5
Genomic and cartography
GoldenPath hg38 (UCSC)GPX5  -     chr6:28526012-28534951 +  6p22.1   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)GPX5  -     6p22.1   [Description]    (hg19-Feb_2009)
EnsemblGPX5 - 6p22.1 [CytoView hg19]  GPX5 - 6p22.1 [CytoView hg38]
Mapping of homologs : NCBIGPX5 [Mapview hg19]  GPX5 [Mapview hg38]
OMIM603435   
Gene and transcription
Genbank (Entrez)AJ005277 AK093099 BC128159 BC128160 BX103177
RefSeq transcript (Entrez)NM_001509 NM_003996
RefSeq genomic (Entrez)NC_000006 NG_047054 NT_113891
Consensus coding sequences : CCDS (NCBI)GPX5
Cluster EST : UnigeneHs.248129 [ NCBI ]
CGAP (NCI)Hs.248129
Alternative Splicing GalleryENSG00000224586
Gene ExpressionGPX5 [ NCBI-GEO ]   GPX5 [ EBI - ARRAY_EXPRESS ]   GPX5 [ SEEK ]   GPX5 [ MEM ]
Gene Expression Viewer (FireBrowse)GPX5 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevestigatorExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)2880
GTEX Portal (Tissue expression)GPX5
Human Protein AtlasENSG00000224586-GPX5 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtO75715   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtO75715  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProO75715
Splice isoforms : SwissVarO75715
Catalytic activity : Enzyme1.11.1.9 [ Enzyme-Expasy ]   1.11.1.91.11.1.9 [ IntEnz-EBI ]   1.11.1.9 [ BRENDA ]   1.11.1.9 [ KEGG ]   
PhosPhoSitePlusO75715
Domaine pattern : Prosite (Expaxy)GLUTATHIONE_PEROXID_1 (PS00460)    GLUTATHIONE_PEROXID_2 (PS00763)    GLUTATHIONE_PEROXID_3 (PS51355)   
Domains : Interpro (EBI)Glutathione_peroxidase    GPX_AS    GPX_CS    Thioredoxin-like_sf   
Domain families : Pfam (Sanger)GSHPx (PF00255)   
Domain families : Pfam (NCBI)pfam00255   
Conserved Domain (NCBI)GPX5
DMDM Disease mutations2880
Blocks (Seattle)GPX5
PDB (SRS)2I3Y   
PDB (PDBSum)2I3Y   
PDB (IMB)2I3Y   
PDB (RSDB)2I3Y   
Structural Biology KnowledgeBase2I3Y   
SCOP (Structural Classification of Proteins)2I3Y   
CATH (Classification of proteins structures)2I3Y   
SuperfamilyO75715
Human Protein Atlas [tissue]ENSG00000224586-GPX5 [tissue]
Peptide AtlasO75715
HPRD11941
IPIIPI00026802   IPI00022660   
Protein Interaction databases
DIP (DOE-UCLA)O75715
IntAct (EBI)O75715
FunCoupENSG00000224586
BioGRIDGPX5
STRING (EMBL)GPX5
ZODIACGPX5
Ontologies - Pathways
QuickGOO75715
Ontology : AmiGOglutathione peroxidase activity  extracellular region  lipid metabolic process  cellular response to oxidative stress  oxidation-reduction process  cellular oxidant detoxification  
Ontology : EGO-EBIglutathione peroxidase activity  extracellular region  lipid metabolic process  cellular response to oxidative stress  oxidation-reduction process  cellular oxidant detoxification  
Pathways : KEGGGlutathione metabolism    Arachidonic acid metabolism    Thyroid hormone synthesis   
NDEx NetworkGPX5
Atlas of Cancer Signalling NetworkGPX5
Wikipedia pathwaysGPX5
Orthology - Evolution
OrthoDB2880
GeneTree (enSembl)ENSG00000224586
Phylogenetic Trees/Animal Genes : TreeFamGPX5
HOVERGENO75715
HOGENOMO75715
Homologs : HomoloGeneGPX5
Homology/Alignments : Family Browser (UCSC)GPX5
Gene fusions - Rearrangements
Fusion : MitelmanXRCC6/GPX5 [22q13.2/6p22.1]  [t(6;22)(p22;q13)]  
Fusion PortalXRCC6 22q13.2 GPX5 6p22.1 BRCA
Fusion : QuiverGPX5
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerGPX5 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)GPX5
dbVarGPX5
ClinVarGPX5
1000_GenomesGPX5 
Exome Variant ServerGPX5
ExAC (Exome Aggregation Consortium)ENSG00000224586
GNOMAD BrowserENSG00000224586
Varsome BrowserGPX5
Genetic variants : HAPMAP2880
Genomic Variants (DGV)GPX5 [DGVbeta]
DECIPHERGPX5 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisGPX5 
Mutations
ICGC Data PortalGPX5 
TCGA Data PortalGPX5 
Broad Tumor PortalGPX5
OASIS PortalGPX5 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICGPX5  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDGPX5
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch GPX5
DgiDB (Drug Gene Interaction Database)GPX5
DoCM (Curated mutations)GPX5 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)GPX5 (select a term)
intoGenGPX5
Cancer3DGPX5(select the gene name)
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM603435   
Orphanet
DisGeNETGPX5
MedgenGPX5
Genetic Testing Registry GPX5
NextProtO75715 [Medical]
TSGene2880
GENETestsGPX5
Target ValidationGPX5
Huge Navigator GPX5 [HugePedia]
snp3D : Map Gene to Disease2880
BioCentury BCIQGPX5
ClinGenGPX5
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD2880
Chemical/Pharm GKB GenePA28953
Clinical trialGPX5
Miscellaneous
canSAR (ICR)GPX5 (select the gene name)
Probes
Litterature
PubMed18 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineGPX5
EVEXGPX5
GoPubMedGPX5
iHOPGPX5
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

Search in all EBI   NCBI

© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Tue Nov 6 11:09:28 CET 2018

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