GPX5 (glutathione peroxidase 5)

2003-08-01  

Identity

HGNC
GPX5
LOCATION
6p22.1
LOCUSID
2880
ALIAS
EGLP,GPx-5,GSHPx-5,HEL-S-75p
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 2880
MIM: 603435
HGNC: 4557
Ensembl: ENSG00000224586

Variants:

dbSNP: 2880
ClinVar: 2880
TCGA: ENSG00000224586
COSMIC: GPX5

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000224586ENST00000412168O75715
ENSG00000224586ENST00000412168V9HWN8
ENSG00000224586ENST00000469384O75715

Expression (GTEx)

0
1
2
3
4
5
6
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Glutathione metabolismKEGGko00480
Arachidonic acid metabolismKEGGko00590
Glutathione metabolismKEGGhsa00480
Arachidonic acid metabolismKEGGhsa00590
Thyroid hormone synthesisKEGGhsa04918
Thyroid hormone synthesisKEGGko04918
Cellular responses to stressREACTOMER-HSA-2262752
Detoxification of Reactive Oxygen SpeciesREACTOMER-HSA-3299685

PharmGKB

Entity IDNameTypeEvidenceAssociationPKPDPMIDs
PA443622Carcinoma, Non-Small-Cell LungDiseaseClinicalAnnotationassociatedPD21636554
PA448803carboplatinChemicalClinicalAnnotationassociatedPD21636554
PA449014cisplatinChemicalClinicalAnnotationassociatedPD21636554
PA449748gemcitabineChemicalClinicalAnnotationassociatedPD21636554

References

Pubmed IDYearTitleCitations
199131212009Gene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip.85
202004262010Glutathione pathway genetic polymorphisms and lung cancer survival after platinum-based chemotherapy.20
206280862010Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study.11

Citation

Dessen P

GPX5 (glutathione peroxidase 5)

Atlas Genet Cytogenet Oncol Haematol. 2003-08-01

Online version: http://atlasgeneticsoncology.org/gene/40748/gpx5