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GPX6 (glutathione peroxidase 6)

Identity

Alias_namesGPXP3
glutathione peroxidase pseudogene 3
glutathione peroxidase 6 (olfactory)
Other aliasGPX5p
GPx-6
GSHPx-6
dJ1186N24
dJ1186N24.1
HGNC (Hugo) GPX6
LocusID (NCBI) 257202
Atlas_Id 54346
Location 6p22.1  [Link to chromosome band 6p22]
Location_base_pair Starts at 28503296 and ends at 28515793 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
CMTR1 (6p21.2) / GPX6 (6p22.1)RREB1 (6p24.3) / GPX6 (6p22.1)FTSJD2 GPX6 6p22.1
RREB1 6p24.3 / GPX6 6p22.1

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


Other Solid tumors implicated (Data extracted from papers in the Atlas) [ 2 ]
  t(6;6)(p21;p22) CMTR1/GPX6
t(6;6)(p22;p24) RREB1/GPX6


External links

Nomenclature
HGNC (Hugo)GPX6   4558
Cards
Entrez_Gene (NCBI)GPX6  257202  glutathione peroxidase 6
AliasesGPX5p; GPXP3; GPx-6; GSHPx-6; 
dJ1186N24; dJ1186N24.1
GeneCards (Weizmann)GPX6
Ensembl hg19 (Hinxton)ENSG00000198704 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000198704 [Gene_View]  ENSG00000198704 [Sequence]  chr6:28503296-28515793 [Contig_View]  GPX6 [Vega]
ICGC DataPortalENSG00000198704
TCGA cBioPortalGPX6
AceView (NCBI)GPX6
Genatlas (Paris)GPX6
WikiGenes257202
SOURCE (Princeton)GPX6
Genetics Home Reference (NIH)GPX6
Genomic and cartography
GoldenPath hg38 (UCSC)GPX6  -     chr6:28503296-28515793 -  6p22.1   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)GPX6  -     6p22.1   [Description]    (hg19-Feb_2009)
EnsemblGPX6 - 6p22.1 [CytoView hg19]  GPX6 - 6p22.1 [CytoView hg38]
Mapping of homologs : NCBIGPX6 [Mapview hg19]  GPX6 [Mapview hg38]
OMIM607913   
Gene and transcription
Genbank (Entrez)AY324826 BC133691 BC148315
RefSeq transcript (Entrez)NM_182701
RefSeq genomic (Entrez)NC_000006 NT_113891
Consensus coding sequences : CCDS (NCBI)GPX6
Cluster EST : UnigeneHs.448570 [ NCBI ]
CGAP (NCI)Hs.448570
Alternative Splicing GalleryENSG00000198704
Gene ExpressionGPX6 [ NCBI-GEO ]   GPX6 [ EBI - ARRAY_EXPRESS ]   GPX6 [ SEEK ]   GPX6 [ MEM ]
Gene Expression Viewer (FireBrowse)GPX6 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevestigatorExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)257202
GTEX Portal (Tissue expression)GPX6
Human Protein AtlasENSG00000198704-GPX6 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtP59796   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtP59796  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProP59796
Splice isoforms : SwissVarP59796
Catalytic activity : Enzyme1.11.1.9 [ Enzyme-Expasy ]   1.11.1.91.11.1.9 [ IntEnz-EBI ]   1.11.1.9 [ BRENDA ]   1.11.1.9 [ KEGG ]   
PhosPhoSitePlusP59796
Domaine pattern : Prosite (Expaxy)GLUTATHIONE_PEROXID_1 (PS00460)    GLUTATHIONE_PEROXID_2 (PS00763)    GLUTATHIONE_PEROXID_3 (PS51355)   
Domains : Interpro (EBI)Glutathione_peroxidase    GPX_AS    GPX_CS    Thioredoxin-like_sf   
Domain families : Pfam (Sanger)GSHPx (PF00255)   
Domain families : Pfam (NCBI)pfam00255   
Conserved Domain (NCBI)GPX6
DMDM Disease mutations257202
Blocks (Seattle)GPX6
SuperfamilyP59796
Human Protein Atlas [tissue]ENSG00000198704-GPX6 [tissue]
Peptide AtlasP59796
HPRD12132
IPIIPI00335668   IPI00930233   IPI00946075   
Protein Interaction databases
DIP (DOE-UCLA)P59796
IntAct (EBI)P59796
FunCoupENSG00000198704
BioGRIDGPX6
STRING (EMBL)GPX6
ZODIACGPX6
Ontologies - Pathways
QuickGOP59796
Ontology : AmiGOglutathione peroxidase activity  extracellular region  response to oxidative stress  oxidation-reduction process  cellular oxidant detoxification  
Ontology : EGO-EBIglutathione peroxidase activity  extracellular region  response to oxidative stress  oxidation-reduction process  cellular oxidant detoxification  
Pathways : KEGGGlutathione metabolism    Arachidonic acid metabolism    Thyroid hormone synthesis   
NDEx NetworkGPX6
Atlas of Cancer Signalling NetworkGPX6
Wikipedia pathwaysGPX6
Orthology - Evolution
OrthoDB257202
GeneTree (enSembl)ENSG00000198704
Phylogenetic Trees/Animal Genes : TreeFamGPX6
HOVERGENP59796
HOGENOMP59796
Homologs : HomoloGeneGPX6
Homology/Alignments : Family Browser (UCSC)GPX6
Gene fusions - Rearrangements
Fusion : MitelmanCMTR1/GPX6 [6p21.2/6p22.1]  [t(6;6)(p21;p22)]  
Fusion : MitelmanRREB1/GPX6 [6p24.3/6p22.1]  [t(6;6)(p22;p24)]  
Fusion PortalFTSJD2 GPX6 6p22.1 KIRC
Fusion PortalRREB1 6p24.3 GPX6 6p22.1 BRCA
Fusion : QuiverGPX6
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerGPX6 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)GPX6
dbVarGPX6
ClinVarGPX6
1000_GenomesGPX6 
Exome Variant ServerGPX6
ExAC (Exome Aggregation Consortium)ENSG00000198704
GNOMAD BrowserENSG00000198704
Varsome BrowserGPX6
Genetic variants : HAPMAP257202
Genomic Variants (DGV)GPX6 [DGVbeta]
DECIPHERGPX6 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisGPX6 
Mutations
ICGC Data PortalGPX6 
TCGA Data PortalGPX6 
Broad Tumor PortalGPX6
OASIS PortalGPX6 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICGPX6  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDGPX6
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch GPX6
DgiDB (Drug Gene Interaction Database)GPX6
DoCM (Curated mutations)GPX6 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)GPX6 (select a term)
intoGenGPX6
Cancer3DGPX6(select the gene name)
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM607913   
Orphanet
DisGeNETGPX6
MedgenGPX6
Genetic Testing Registry GPX6
NextProtP59796 [Medical]
TSGene257202
GENETestsGPX6
Target ValidationGPX6
Huge Navigator GPX6 [HugePedia]
snp3D : Map Gene to Disease257202
BioCentury BCIQGPX6
ClinGenGPX6
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD257202
Chemical/Pharm GKB GenePA28954
Clinical trialGPX6
Miscellaneous
canSAR (ICR)GPX6 (select the gene name)
Probes
Litterature
PubMed10 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineGPX6
EVEXGPX6
GoPubMedGPX6
iHOPGPX6
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Tue Nov 6 11:09:29 CET 2018

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