GPX7 (glutathione peroxidase 7)

2007-02-01 Affiliation

Identity

HGNC

GPX7

LOCATION

1p32.3

LOCUSID

2882

ALIAS

CL683,GPX6,GPx-7,GSHPx-7,NPGPx

FUSION GENES

Show Gene Fusions

Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool

Other Information

Locus ID:

NCBI: 2882
MIM: 615784
HGNC: 4559
Ensembl: ENSG00000116157

Variants:

dbSNP: 2882
ClinVar: 2882
TCGA: ENSG00000116157
COSMIC: GPX7

RNA/Proteins

Gene ID	Transcript ID	Uniprot
ENSG00000116157	ENST00000361314	Q96SL4

Expression (GTEx)

Adipose - Subcutaneous

Adipose - Visceral

Adrenal Gland

Artery - Aorta

Artery - Tibial

Bladder

Brain - Amygdala

Brain - Anterior cingulate cortex

Brain - Caudate

Brain - Cerebellar Hemisphere

Brain - Cerebellum

Brain - Cortex

Brain - Frontal Cortex

Brain - Hippocampus

Brain - Hypothalamus

Brain - Nucleus accumbens

Brain - Putamen

Brain - Spinal cord

Brain - Substantia nigra

Breast - Mammary Tissue

Cells - Cultured fibroblasts

Cells - EBV - transformed lymphocytes

Cervix - Ectocervix

Cervix - Endocervix

Colon - Sigmoid

Colon - Transverse

Esophagus - Gastroesophageal Junction

Esophagus - Mucosa

Esophagus - Muscularis

Fallopian Tube

Heart - Atrial Appendage

Heart - Left Ventricle

Kidney - Cortex

Kidney - Medulla

Liver

Lung

Minor Salivary Gland

Muscle - Skeletal

Nerve - Tibial

Ovary

Pancreas

Pituitary

Prostate

Skin - Not Sun Exposed

Skin - Sun Exposed

Small Intestine - Terminal Ileum

Spleen

Stomach

Testis

Thyroid

Uterus

Vagina

Whole Blood

Pathways

Pathway	Source	External ID
Glutathione metabolism	KEGG	ko00480
Arachidonic acid metabolism	KEGG	ko00590
Glutathione metabolism	KEGG	hsa00480
Arachidonic acid metabolism	KEGG	hsa00590
Thyroid hormone synthesis	KEGG	hsa04918
Thyroid hormone synthesis	KEGG	ko04918
Cellular responses to stress	REACTOME	R-HSA-2262752
Detoxification of Reactive Oxygen Species	REACTOME	R-HSA-3299685

References

Pubmed ID	Year	Title	Citations
19913121	2009	Gene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip.	85
21215271	2011	Two endoplasmic reticulum PDI peroxidases increase the efficiency of the use of peroxide during disulfide bond formation.	70
23123197	2012	Loss of the oxidative stress sensor NPGPx compromises GRP78 chaperone activity and induces systemic disease.	47
15294905	2004	Identification of a novel putative non-selenocysteine containing phospholipid hydroperoxide glutathione peroxidase (NPGPx) essential for alleviating oxidative stress generated from polyunsaturated fatty acids in breast cancer cells.	29
23919619	2014	Glutathione peroxidase 7 utilizes hydrogen peroxide generated by Ero1α to promote oxidative protein folding.	28
20819778	2010	MicroRNA-related genetic variations as predictors for risk of second primary tumor and/or recurrence in patients with early-stage head and neck cancer.	21
20200426	2010	Glutathione pathway genetic polymorphisms and lung cancer survival after platinum-based chemotherapy.	20
25586538	2015	Candidate pathway-based genetic association study of platinum and platinum-taxane related toxicity in a cohort of primary lung cancer patients.	12
20628086	2010	Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study.	11
23454490	2013	Protein disulfide isomerase and glutathione are alternative substrates in the one Cys catalytic cycle of glutathione peroxidase 7.	8

Citation

Dessen P

GPX7 (glutathione peroxidase 7)

Atlas Genet Cytogenet Oncol Haematol. 2007-02-01

Online version: http://atlasgeneticsoncology.org/gene/43719/gpx7