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GPX7 (glutathione peroxidase 7)

Identity

Other namesCL683
GPX6
GPx-7
GSHPx-7
NPGPx
HGNC (Hugo) GPX7
LocusID (NCBI) 2882
Atlas_Id 43719
Location 1p32.3  [Link to chromosome band 1p32]
Location_base_pair Starts at 53068043 and ends at 53074723 bp from pter ( according to hg19-Feb_2009)
Fusion genes
(updated 2016)
GPX7 (1p32.3) / CTGF (6q23.2)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


Other Solid tumors implicated (Data extracted from papers in the Atlas) [ 0 ]
  Esophagus: Barrett's esophagus, dysplasia and adenocarcinoma

External links

Nomenclature
HGNC (Hugo)GPX7   4559
Cards
Entrez_Gene (NCBI)GPX7  2882  glutathione peroxidase 7
AliasesCL683; GPX6; GPx-7; GSHPx-7; 
NPGPx
GeneCards (Weizmann)GPX7
Ensembl hg19 (Hinxton)ENSG00000116157 [Gene_View]  chr1:53068043-53074723 [Contig_View]  GPX7 [Vega]
Ensembl hg38 (Hinxton)ENSG00000116157 [Gene_View]  chr1:53068043-53074723 [Contig_View]  GPX7 [Vega]
ICGC DataPortalENSG00000116157
TCGA cBioPortalGPX7
AceView (NCBI)GPX7
Genatlas (Paris)GPX7
WikiGenes2882
SOURCE (Princeton)GPX7
Genomic and cartography
GoldenPath hg19 (UCSC)GPX7  -     chr1:53068043-53074723 +  1p32.3   [Description]    (hg19-Feb_2009)
GoldenPath hg38 (UCSC)GPX7  -     1p32.3   [Description]    (hg38-Dec_2013)
EnsemblGPX7 - 1p32.3 [CytoView hg19]  GPX7 - 1p32.3 [CytoView hg38]
Mapping of homologs : NCBIGPX7 [Mapview hg19]  GPX7 [Mapview hg38]
OMIM615784   
Gene and transcription
Genbank (Entrez)AF091092 AF320068 AK027683 AY358402 BC032788
RefSeq transcript (Entrez)NM_015696
RefSeq genomic (Entrez)NC_000001 NC_018912 NT_032977 NW_004929290
Consensus coding sequences : CCDS (NCBI)GPX7
Cluster EST : UnigeneHs.43728 [ NCBI ]
CGAP (NCI)Hs.43728
Alternative Splicing GalleryENSG00000116157
Gene ExpressionGPX7 [ NCBI-GEO ]   GPX7 [ EBI - ARRAY_EXPRESS ]   GPX7 [ SEEK ]   GPX7 [ MEM ]
Gene Expression Viewer (FireBrowse)GPX7 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)2882
GTEX Portal (Tissue expression)GPX7
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ96SL4 (Uniprot)
NextProtQ96SL4  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ96SL4
Splice isoforms : SwissVarQ96SL4 (Swissvar)
Catalytic activity : Enzyme1.11.1.9 [ Enzyme-Expasy ]   1.11.1.91.11.1.9 [ IntEnz-EBI ]   1.11.1.9 [ BRENDA ]   1.11.1.9 [ KEGG ]   
PhosPhoSitePlusQ96SL4
Domaine pattern : Prosite (Expaxy)GLUTATHIONE_PEROXID_1 (PS00460)    GLUTATHIONE_PEROXID_2 (PS00763)    GLUTATHIONE_PEROXID_3 (PS51355)   
Domains : Interpro (EBI)Glut_perox_Gpx7    Glutathione_peroxidase    GPX_AS    GPX_CS    Thioredoxin-like_fold   
Domain families : Pfam (Sanger)GSHPx (PF00255)   
Domain families : Pfam (NCBI)pfam00255   
DMDM Disease mutations2882
Blocks (Seattle)GPX7
PDB (SRS)2P31   
PDB (PDBSum)2P31   
PDB (IMB)2P31   
PDB (RSDB)2P31   
Structural Biology KnowledgeBase2P31   
SCOP (Structural Classification of Proteins)2P31   
CATH (Classification of proteins structures)2P31   
SuperfamilyQ96SL4
Human Protein AtlasENSG00000116157
Peptide AtlasQ96SL4
HPRD13606
IPIIPI00045798   
Protein Interaction databases
DIP (DOE-UCLA)Q96SL4
IntAct (EBI)Q96SL4
FunCoupENSG00000116157
BioGRIDGPX7
STRING (EMBL)GPX7
ZODIACGPX7
Ontologies - Pathways
QuickGOQ96SL4
Ontology : AmiGOresponse to reactive oxygen species  catalase activity  peroxidase activity  glutathione peroxidase activity  protein binding  extracellular region  endoplasmic reticulum  endoplasmic reticulum lumen  oxidation-reduction process  cellular oxidant detoxification  cellular oxidant detoxification  cellular oxidant detoxification  
Ontology : EGO-EBIresponse to reactive oxygen species  catalase activity  peroxidase activity  glutathione peroxidase activity  protein binding  extracellular region  endoplasmic reticulum  endoplasmic reticulum lumen  oxidation-reduction process  cellular oxidant detoxification  cellular oxidant detoxification  cellular oxidant detoxification  
Pathways : KEGGGlutathione metabolism    Arachidonic acid metabolism    Thyroid hormone synthesis   
NDEx Network
Atlas of Cancer Signalling NetworkGPX7
Wikipedia pathwaysGPX7
Orthology - Evolution
OrthoDB2882
GeneTree (enSembl)ENSG00000116157
Phylogenetic Trees/Animal Genes : TreeFamGPX7
Homologs : HomoloGeneGPX7
Homology/Alignments : Family Browser (UCSC)GPX7
Gene fusions - Rearrangements
Polymorphisms : SNP, variants
NCBI Variation ViewerGPX7 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)GPX7
dbVarGPX7
ClinVarGPX7
1000_GenomesGPX7 
Exome Variant ServerGPX7
ExAC (Exome Aggregation Consortium)GPX7 (select the gene name)
Genetic variants : HAPMAP2882
Genomic Variants (DGV)GPX7 [DGVbeta]
Mutations
ICGC Data PortalGPX7 
TCGA Data PortalGPX7 
Broad Tumor PortalGPX7
OASIS PortalGPX7 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICGPX7 
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch GPX7
DgiDB (Drug Gene Interaction Database)GPX7
DoCM (Curated mutations)GPX7 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)GPX7 (select a term)
intoGenGPX7
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] 
Diseases
DECIPHER (Syndromes)1:53068043-53074723  ENSG00000116157
CONAN: Copy Number AnalysisGPX7 
Mutations and Diseases : HGMDGPX7
OMIM615784   
MedgenGPX7
Genetic Testing Registry GPX7
NextProtQ96SL4 [Medical]
TSGene2882
GENETestsGPX7
Huge Navigator GPX7 [HugePedia]
snp3D : Map Gene to Disease2882
BioCentury BCIQGPX7
ClinGenGPX7
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD2882
Chemical/Pharm GKB GenePA28955
Clinical trialGPX7
Miscellaneous
canSAR (ICR)GPX7 (select the gene name)
Probes
Litterature
PubMed26 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineGPX7
EVEXGPX7
GoPubMedGPX7
iHOPGPX7
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Tue Aug 9 19:03:24 CEST 2016

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