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GRAP (GRB2-related adaptor protein)

Identity

Other alias-
HGNC (Hugo) GRAP
LocusID (NCBI) 10750
Atlas_Id 43299
Location 17p11.2  [Link to chromosome band 17p11]
Location_base_pair Starts at 19020656 and ends at 19047052 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2016)
FAM83G (17p11.2) / GRAP (17p11.2)GRAP (17p11.2) / ZNF574 (19q13.2)FAM83G 17p11.2 / GRAP 17p11.2

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)GRAP   4562
Cards
Entrez_Gene (NCBI)GRAP  10750  GRB2-related adaptor protein
Aliases
GeneCards (Weizmann)GRAP
Ensembl hg19 (Hinxton)ENSG00000154016 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000154016 [Gene_View]  chr17:19020656-19047052 [Contig_View]  GRAP [Vega]
ICGC DataPortalENSG00000154016
TCGA cBioPortalGRAP
AceView (NCBI)GRAP
Genatlas (Paris)GRAP
WikiGenes10750
SOURCE (Princeton)GRAP
Genetics Home Reference (NIH)GRAP
Genomic and cartography
GoldenPath hg38 (UCSC)GRAP  -     chr17:19020656-19047052 -  17p11.2   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)GRAP  -     17p11.2   [Description]    (hg19-Feb_2009)
EnsemblGRAP - 17p11.2 [CytoView hg19]  GRAP - 17p11.2 [CytoView hg38]
Mapping of homologs : NCBIGRAP [Mapview hg19]  GRAP [Mapview hg38]
OMIM604330   
Gene and transcription
Genbank (Entrez)AI362516 BC035856 BC063035 BG684099 BI906472
RefSeq transcript (Entrez)NM_001330148 NM_006613
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)GRAP
Cluster EST : UnigeneHs.567416 [ NCBI ]
CGAP (NCI)Hs.567416
Alternative Splicing GalleryENSG00000154016
Gene ExpressionGRAP [ NCBI-GEO ]   GRAP [ EBI - ARRAY_EXPRESS ]   GRAP [ SEEK ]   GRAP [ MEM ]
Gene Expression Viewer (FireBrowse)GRAP [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)10750
GTEX Portal (Tissue expression)GRAP
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ13588   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ13588  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ13588
Splice isoforms : SwissVarQ13588
PhosPhoSitePlusQ13588
Domaine pattern : Prosite (Expaxy)SH2 (PS50001)    SH3 (PS50002)   
Domains : Interpro (EBI)SH2    SH3_2    SH3_domain   
Domain families : Pfam (Sanger)SH2 (PF00017)    SH3_1 (PF00018)    SH3_2 (PF07653)   
Domain families : Pfam (NCBI)pfam00017    pfam00018    pfam07653   
Domain families : Smart (EMBL)SH2 (SM00252)  SH3 (SM00326)  
Conserved Domain (NCBI)GRAP
DMDM Disease mutations10750
Blocks (Seattle)GRAP
SuperfamilyQ13588
Human Protein AtlasENSG00000154016
Peptide AtlasQ13588
HPRD05062
IPIIPI00013864   IPI00792372   
Protein Interaction databases
DIP (DOE-UCLA)Q13588
IntAct (EBI)Q13588
FunCoupENSG00000154016
BioGRIDGRAP
STRING (EMBL)GRAP
ZODIACGRAP
Ontologies - Pathways
QuickGOQ13588
Ontology : AmiGOnon-membrane spanning protein tyrosine kinase activity  SH3/SH2 adaptor activity  receptor binding  protein binding  cytoplasm  cytosol  transmembrane receptor protein tyrosine kinase signaling pathway  Ras protein signal transduction  cell-cell signaling  positive regulation of signal transduction  cell migration  cell differentiation  extrinsic component of cytoplasmic side of plasma membrane  peptidyl-tyrosine autophosphorylation  regulation of cell proliferation  innate immune response  
Ontology : EGO-EBInon-membrane spanning protein tyrosine kinase activity  SH3/SH2 adaptor activity  receptor binding  protein binding  cytoplasm  cytosol  transmembrane receptor protein tyrosine kinase signaling pathway  Ras protein signal transduction  cell-cell signaling  positive regulation of signal transduction  cell migration  cell differentiation  extrinsic component of cytoplasmic side of plasma membrane  peptidyl-tyrosine autophosphorylation  regulation of cell proliferation  innate immune response  
NDEx NetworkGRAP
Atlas of Cancer Signalling NetworkGRAP
Wikipedia pathwaysGRAP
Orthology - Evolution
OrthoDB10750
GeneTree (enSembl)ENSG00000154016
Phylogenetic Trees/Animal Genes : TreeFamGRAP
HOVERGENQ13588
HOGENOMQ13588
Homologs : HomoloGeneGRAP
Homology/Alignments : Family Browser (UCSC)GRAP
Gene fusions - Rearrangements
Fusion : MitelmanFAM83G/GRAP [17p11.2/17p11.2]  [t(17;17)(p11;p11)]  
Fusion: TCGAFAM83G 17p11.2 GRAP 17p11.2 HNSC
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerGRAP [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)GRAP
dbVarGRAP
ClinVarGRAP
1000_GenomesGRAP 
Exome Variant ServerGRAP
ExAC (Exome Aggregation Consortium)GRAP (select the gene name)
Genetic variants : HAPMAP10750
Genomic Variants (DGV)GRAP [DGVbeta]
DECIPHERGRAP [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisGRAP 
Mutations
ICGC Data PortalGRAP 
TCGA Data PortalGRAP 
Broad Tumor PortalGRAP
OASIS PortalGRAP [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICGRAP  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDGRAP
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch GRAP
DgiDB (Drug Gene Interaction Database)GRAP
DoCM (Curated mutations)GRAP (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)GRAP (select a term)
intoGenGRAP
Cancer3DGRAP(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM604330   
Orphanet
MedgenGRAP
Genetic Testing Registry GRAP
NextProtQ13588 [Medical]
TSGene10750
GENETestsGRAP
Target ValidationGRAP
Huge Navigator GRAP [HugePedia]
snp3D : Map Gene to Disease10750
BioCentury BCIQGRAP
ClinGenGRAP
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD10750
Chemical/Pharm GKB GenePA28958
Clinical trialGRAP
Miscellaneous
canSAR (ICR)GRAP (select the gene name)
Probes
Litterature
PubMed16 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineGRAP
EVEXGRAP
GoPubMedGRAP
iHOPGRAP
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Mon Sep 25 19:10:33 CEST 2017

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