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GRAP2 (GRB2-related adaptor protein 2)

Identity

Alias_symbol (synonym)Grf40
GrbX
GRBLG
GADS
Mona
Other aliasGRAP-2
GRB2L
GRID
GRPL
P38
HGNC (Hugo) GRAP2
LocusID (NCBI) 9402
Atlas_Id 49932
Location 22q13.1  [Link to chromosome band 22q13]
Location_base_pair Starts at 39926591 and ends at 39973342 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2016)
COL1A1 (17q21.33) / GRAP2 (22q13.1)GRAP2 (22q13.1) / MLXIP (12q24.31)NF2 (22q12.2) / GRAP2 (22q13.1)
TBC1D22A (22q13.31) / GRAP2 (22q13.1)NF2 22q12.2 / GRAP2 22q13.1TBC1D22A 22q13.31 / GRAP2 22q13.1

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)GRAP2   4563
Cards
Entrez_Gene (NCBI)GRAP2  9402  GRB2-related adaptor protein 2
AliasesGADS; GRAP-2; GRB2L; GRBLG; 
GRID; GRPL; GrbX; Grf40; Mona; P38
GeneCards (Weizmann)GRAP2
Ensembl hg19 (Hinxton)ENSG00000100351 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000100351 [Gene_View]  chr22:39926591-39973342 [Contig_View]  GRAP2 [Vega]
ICGC DataPortalENSG00000100351
TCGA cBioPortalGRAP2
AceView (NCBI)GRAP2
Genatlas (Paris)GRAP2
WikiGenes9402
SOURCE (Princeton)GRAP2
Genetics Home Reference (NIH)GRAP2
Genomic and cartography
GoldenPath hg38 (UCSC)GRAP2  -     chr22:39926591-39973342 +  22q13.1   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)GRAP2  -     22q13.1   [Description]    (hg19-Feb_2009)
EnsemblGRAP2 - 22q13.1 [CytoView hg19]  GRAP2 - 22q13.1 [CytoView hg38]
Mapping of homologs : NCBIGRAP2 [Mapview hg19]  GRAP2 [Mapview hg38]
OMIM604518   
Gene and transcription
Genbank (Entrez)AF042380 AF090456 AF102694 AF121002 AF129476
RefSeq transcript (Entrez)NM_001291824 NM_001291825 NM_001291826 NM_001291828 NM_004810
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)GRAP2
Cluster EST : UnigeneHs.517499 [ NCBI ]
CGAP (NCI)Hs.517499
Alternative Splicing GalleryENSG00000100351
Gene ExpressionGRAP2 [ NCBI-GEO ]   GRAP2 [ EBI - ARRAY_EXPRESS ]   GRAP2 [ SEEK ]   GRAP2 [ MEM ]
Gene Expression Viewer (FireBrowse)GRAP2 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)9402
GTEX Portal (Tissue expression)GRAP2
Protein : pattern, domain, 3D structure
UniProt/SwissProtO75791   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtO75791  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProO75791
Splice isoforms : SwissVarO75791
PhosPhoSitePlusO75791
Domaine pattern : Prosite (Expaxy)SH2 (PS50001)    SH3 (PS50002)   
Domains : Interpro (EBI)SH2    SH3_domain   
Domain families : Pfam (Sanger)SH2 (PF00017)    SH3_1 (PF00018)   
Domain families : Pfam (NCBI)pfam00017    pfam00018   
Domain families : Smart (EMBL)SH2 (SM00252)  SH3 (SM00326)  
Conserved Domain (NCBI)GRAP2
DMDM Disease mutations9402
Blocks (Seattle)GRAP2
PDB (SRS)5GJH   
PDB (PDBSum)5GJH   
PDB (IMB)5GJH   
PDB (RSDB)5GJH   
Structural Biology KnowledgeBase5GJH   
SCOP (Structural Classification of Proteins)5GJH   
CATH (Classification of proteins structures)5GJH   
SuperfamilyO75791
Human Protein AtlasENSG00000100351
Peptide AtlasO75791
HPRD05156
IPIIPI00026928   IPI01012757   IPI01014070   IPI00922940   IPI00922285   IPI00922833   IPI00878281   
Protein Interaction databases
DIP (DOE-UCLA)O75791
IntAct (EBI)O75791
FunCoupENSG00000100351
BioGRIDGRAP2
STRING (EMBL)GRAP2
ZODIACGRAP2
Ontologies - Pathways
QuickGOO75791
Ontology : AmiGOnon-membrane spanning protein tyrosine kinase activity  SH3/SH2 adaptor activity  receptor binding  protein binding  nucleus  cytoplasm  endosome  cytosol  transmembrane receptor protein tyrosine kinase signaling pathway  Ras protein signal transduction  cell-cell signaling  positive regulation of signal transduction  cell migration  cell differentiation  extrinsic component of cytoplasmic side of plasma membrane  T cell costimulation  peptidyl-tyrosine autophosphorylation  Fc-epsilon receptor signaling pathway  regulation of cell proliferation  innate immune response  T cell receptor signaling pathway  
Ontology : EGO-EBInon-membrane spanning protein tyrosine kinase activity  SH3/SH2 adaptor activity  receptor binding  protein binding  nucleus  cytoplasm  endosome  cytosol  transmembrane receptor protein tyrosine kinase signaling pathway  Ras protein signal transduction  cell-cell signaling  positive regulation of signal transduction  cell migration  cell differentiation  extrinsic component of cytoplasmic side of plasma membrane  T cell costimulation  peptidyl-tyrosine autophosphorylation  Fc-epsilon receptor signaling pathway  regulation of cell proliferation  innate immune response  T cell receptor signaling pathway  
Pathways : KEGGT cell receptor signaling pathway   
NDEx NetworkGRAP2
Atlas of Cancer Signalling NetworkGRAP2
Wikipedia pathwaysGRAP2
Orthology - Evolution
OrthoDB9402
GeneTree (enSembl)ENSG00000100351
Phylogenetic Trees/Animal Genes : TreeFamGRAP2
HOVERGENO75791
HOGENOMO75791
Homologs : HomoloGeneGRAP2
Homology/Alignments : Family Browser (UCSC)GRAP2
Gene fusions - Rearrangements
Fusion : MitelmanNF2/GRAP2 [22q12.2/22q13.1]  [t(22;22)(q12;q13)]  
Fusion : MitelmanTBC1D22A/GRAP2 [22q13.31/22q13.1]  [t(22;22)(q13;q13)]  
Fusion: TCGANF2 22q12.2 GRAP2 22q13.1 BRCA
Fusion: TCGATBC1D22A 22q13.31 GRAP2 22q13.1 LUAD
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerGRAP2 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)GRAP2
dbVarGRAP2
ClinVarGRAP2
1000_GenomesGRAP2 
Exome Variant ServerGRAP2
ExAC (Exome Aggregation Consortium)GRAP2 (select the gene name)
Genetic variants : HAPMAP9402
Genomic Variants (DGV)GRAP2 [DGVbeta]
DECIPHERGRAP2 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisGRAP2 
Mutations
ICGC Data PortalGRAP2 
TCGA Data PortalGRAP2 
Broad Tumor PortalGRAP2
OASIS PortalGRAP2 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICGRAP2  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDGRAP2
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch GRAP2
DgiDB (Drug Gene Interaction Database)GRAP2
DoCM (Curated mutations)GRAP2 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)GRAP2 (select a term)
intoGenGRAP2
Cancer3DGRAP2(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM604518   
Orphanet
MedgenGRAP2
Genetic Testing Registry GRAP2
NextProtO75791 [Medical]
TSGene9402
GENETestsGRAP2
Huge Navigator GRAP2 [HugePedia]
snp3D : Map Gene to Disease9402
BioCentury BCIQGRAP2
ClinGenGRAP2
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD9402
Chemical/Pharm GKB GenePA28959
Clinical trialGRAP2
Miscellaneous
canSAR (ICR)GRAP2 (select the gene name)
Probes
Litterature
PubMed69 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineGRAP2
EVEXGRAP2
GoPubMedGRAP2
iHOPGRAP2
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Fri May 19 12:17:55 CEST 2017

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