Identity
HGNC
LOCATION
22q13.1
LOCUSID
ALIAS
GADS,GRAP-2,GRB2L,GRBLG,GRID,GRPL,GrbX,Grf40,Mona,P38
FUSION GENES
Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool
Other Information
Locus ID:
NCBI: 9402
MIM: 604518
HGNC: 4563
Ensembl: ENSG00000100351
Variants:
dbSNP: 9402
ClinVar: 9402
TCGA: ENSG00000100351
COSMIC: GRAP2
RNA/Proteins
Expression (GTEx)
Pathways
Protein levels (Protein atlas)
References
| Pubmed ID | Year | Title | Citations |
|---|---|---|---|
| 27927989 | 2017 | Crystal Structures and Thermodynamic Analysis Reveal Distinct Mechanisms of CD28 Phosphopeptide Binding to the Src Homology 2 (SH2) Domains of Three Adaptor Proteins. | 6 |
| 28289074 | 2017 | T Cell Costimulation by CD6 Is Dependent on Bivalent Binding of a GADS/SLP-76 Complex. | 23 |
| 27927989 | 2017 | Crystal Structures and Thermodynamic Analysis Reveal Distinct Mechanisms of CD28 Phosphopeptide Binding to the Src Homology 2 (SH2) Domains of Three Adaptor Proteins. | 6 |
| 28289074 | 2017 | T Cell Costimulation by CD6 Is Dependent on Bivalent Binding of a GADS/SLP-76 Complex. | 23 |
| 25452106 | 2015 | Modulation of TCR responsiveness by the Grb2-family adaptor, Gads. | 7 |
| 25636200 | 2015 | GADS is required for TCR-mediated calcium influx and cytokine release, but not cellular adhesion, in human T cells. | 12 |
| 25452106 | 2015 | Modulation of TCR responsiveness by the Grb2-family adaptor, Gads. | 7 |
| 25636200 | 2015 | GADS is required for TCR-mediated calcium influx and cytokine release, but not cellular adhesion, in human T cells. | 12 |
| 23399893 | 2013 | Gads (Grb2-related adaptor downstream of Shc) is required for BCR-ABL-mediated lymphoid leukemia. | 4 |
| 23399893 | 2013 | Gads (Grb2-related adaptor downstream of Shc) is required for BCR-ABL-mediated lymphoid leukemia. | 4 |
| 20079431 | 2010 | The Bcr-Abl kinase regulates the actin cytoskeleton via a GADS/Slp-76/Nck1 adaptor protein pathway. | 8 |
| 20237496 | 2010 | New genetic associations detected in a host response study to hepatitis B vaccine. | 37 |
| 20379614 | 2010 | Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. | 78 |
| 21179510 | 2010 | Histidine domain-protein tyrosine phosphatase interacts with Grb2 and GrpL. | 6 |
| 20079431 | 2010 | The Bcr-Abl kinase regulates the actin cytoskeleton via a GADS/Slp-76/Nck1 adaptor protein pathway. | 8 |
Citation
Dessen P
GRAP2 (GRB2 related adaptor protein 2)
Atlas Genet Cytogenet Oncol Haematol. 2007-12-01
Online version: http://atlasgeneticsoncology.org/gene/49932/grap2
