Atlas of Genetics and Cytogenetics in Oncology and Haematology


Home   Genes   Leukemias   Solid Tumors   Cancer-Prone   Deep Insight   Case Reports   Journals  Portal   Teaching   

X Y 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 NA

GREM1 (gremlin 1, DAN family BMP antagonist)

Identity

Alias_namesCKTSF1B1
CRAC1
cysteine knot superfamily 1, BMP antagonist 1
gremlin 1, cysteine knot superfamily, homolog (Xenopus laevis)
gremlin 1
colorectal adenoma and carcinoma 1
Alias_symbol (synonym)DRM
gremlin
DAND2
HMPS
Other aliasC15DUPq
CRCS4
DUP15q
GREMLIN
HMPS1
IHG-2
MPSH
PIG2
HGNC (Hugo) GREM1
LocusID (NCBI) 26585
Atlas_Id 43901
Location 15q13.3  [Link to chromosome band 15q13]
Location_base_pair Starts at 32718004 and ends at 32734669 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2016)
GREM1 (15q13.3) / TP53RK (20q13.12)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)GREM1   2001
Cards
Entrez_Gene (NCBI)GREM1  26585  gremlin 1, DAN family BMP antagonist
AliasesC15DUPq; CKTSF1B1; CRAC1; CRCS4; 
DAND2; DRM; DUP15q; GREMLIN; HMPS; HMPS1; IHG-2; MPSH; PIG2
GeneCards (Weizmann)GREM1
Ensembl hg19 (Hinxton)ENSG00000166923 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000166923 [Gene_View]  chr15:32718004-32734669 [Contig_View]  GREM1 [Vega]
ICGC DataPortalENSG00000166923
TCGA cBioPortalGREM1
AceView (NCBI)GREM1
Genatlas (Paris)GREM1
WikiGenes26585
SOURCE (Princeton)GREM1
Genetics Home Reference (NIH)GREM1
Genomic and cartography
GoldenPath hg38 (UCSC)GREM1  -     chr15:32718004-32734669 +  15q13.3   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)GREM1  -     15q13.3   [Description]    (hg19-Feb_2009)
EnsemblGREM1 - 15q13.3 [CytoView hg19]  GREM1 - 15q13.3 [CytoView hg38]
Mapping of homologs : NCBIGREM1 [Mapview hg19]  GREM1 [Mapview hg38]
OMIM603054   
Gene and transcription
Genbank (Entrez)AF045800 AF110137 AF154054 AK095741 AK095890
RefSeq transcript (Entrez)NM_001191322 NM_001191323 NM_013372
RefSeq genomic (Entrez)NC_000015 NC_018926 NG_033791 NT_187660 NW_011332701 NW_012132920
Consensus coding sequences : CCDS (NCBI)GREM1
Cluster EST : UnigeneHs.40098 [ NCBI ]
CGAP (NCI)Hs.40098
Alternative Splicing GalleryENSG00000166923
Gene ExpressionGREM1 [ NCBI-GEO ]   GREM1 [ EBI - ARRAY_EXPRESS ]   GREM1 [ SEEK ]   GREM1 [ MEM ]
Gene Expression Viewer (FireBrowse)GREM1 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)26585
GTEX Portal (Tissue expression)GREM1
Protein : pattern, domain, 3D structure
UniProt/SwissProtO60565   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtO60565  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProO60565
Splice isoforms : SwissVarO60565
PhosPhoSitePlusO60565
Domains : Interpro (EBI)Cys_knot_C    DAN    Gremlin-1/2   
Domain families : Pfam (Sanger)DAN (PF03045)   
Domain families : Pfam (NCBI)pfam03045   
Domain families : Smart (EMBL)CT (SM00041)  
Conserved Domain (NCBI)GREM1
DMDM Disease mutations26585
Blocks (Seattle)GREM1
PDB (SRS)5AEJ   
PDB (PDBSum)5AEJ   
PDB (IMB)5AEJ   
PDB (RSDB)5AEJ   
Structural Biology KnowledgeBase5AEJ   
SCOP (Structural Classification of Proteins)5AEJ   
CATH (Classification of proteins structures)5AEJ   
SuperfamilyO60565
Human Protein AtlasENSG00000166923
Peptide AtlasO60565
HPRD07048
IPIIPI00298476   IPI00747935   IPI00902753   
Protein Interaction databases
DIP (DOE-UCLA)O60565
IntAct (EBI)O60565
FunCoupENSG00000166923
BioGRIDGREM1
STRING (EMBL)GREM1
ZODIACGREM1
Ontologies - Pathways
QuickGOO60565
Ontology : AmiGOcell morphogenesis  branching involved in ureteric bud morphogenesis  cell migration involved in sprouting angiogenesis  positive regulation of receptor internalization  positive regulation of transcription from RNA polymerase II promoter involved in myocardial precursor cell differentiation  mesenchymal to epithelial transition involved in metanephros morphogenesis  cytokine activity  protein binding  extracellular space  apoptotic process  signal transduction  activation of transmembrane receptor protein tyrosine kinase activity  cell-cell signaling  positive regulation of cell proliferation  proximal/distal pattern formation  cell surface  regulation of epithelial to mesenchymal transition  morphogen activity  collagen fibril organization  transmembrane receptor protein tyrosine kinase activator activity  negative regulation of cell growth  embryonic limb morphogenesis  negative regulation of bone mineralization  negative regulation of BMP signaling pathway  negative regulation of BMP signaling pathway  negative regulation of chondrocyte differentiation  regulation of stress-activated MAPK cascade  negative regulation of osteoblast proliferation  BMP binding  positive regulation of NF-kappaB import into nucleus  negative regulation of apoptotic process  vascular endothelial growth factor receptor 2 binding  positive regulation of angiogenesis  negative regulation of transcription, DNA-templated  positive regulation of transcription from RNA polymerase II promoter  negative regulation of bone remodeling  receptor agonist activity  determination of dorsal identity  positive regulation of NF-kappaB transcription factor activity  regulation of focal adhesion assembly  positive regulation of telomerase activity  limb development  negative regulation of pathway-restricted SMAD protein phosphorylation  ureteric bud formation  positive regulation of protein tyrosine kinase activity  signal transduction by p53 class mediator  negative regulation of monocyte chemotaxis  negative regulation of canonical Wnt signaling pathway  positive regulation of branching involved in ureteric bud morphogenesis  negative regulation of branching involved in ureteric bud morphogenesis  negative regulation of osteoclast proliferation  positive regulation of peptidyl-tyrosine autophosphorylation  negative regulation of bone trabecula formation  negative regulation of bone mineralization involved in bone maturation  positive regulation of receptor activity  positive regulation of cardiac muscle cell differentiation  
Ontology : EGO-EBIcell morphogenesis  branching involved in ureteric bud morphogenesis  cell migration involved in sprouting angiogenesis  positive regulation of receptor internalization  positive regulation of transcription from RNA polymerase II promoter involved in myocardial precursor cell differentiation  mesenchymal to epithelial transition involved in metanephros morphogenesis  cytokine activity  protein binding  extracellular space  apoptotic process  signal transduction  activation of transmembrane receptor protein tyrosine kinase activity  cell-cell signaling  positive regulation of cell proliferation  proximal/distal pattern formation  cell surface  regulation of epithelial to mesenchymal transition  morphogen activity  collagen fibril organization  transmembrane receptor protein tyrosine kinase activator activity  negative regulation of cell growth  embryonic limb morphogenesis  negative regulation of bone mineralization  negative regulation of BMP signaling pathway  negative regulation of BMP signaling pathway  negative regulation of chondrocyte differentiation  regulation of stress-activated MAPK cascade  negative regulation of osteoblast proliferation  BMP binding  positive regulation of NF-kappaB import into nucleus  negative regulation of apoptotic process  vascular endothelial growth factor receptor 2 binding  positive regulation of angiogenesis  negative regulation of transcription, DNA-templated  positive regulation of transcription from RNA polymerase II promoter  negative regulation of bone remodeling  receptor agonist activity  determination of dorsal identity  positive regulation of NF-kappaB transcription factor activity  regulation of focal adhesion assembly  positive regulation of telomerase activity  limb development  negative regulation of pathway-restricted SMAD protein phosphorylation  ureteric bud formation  positive regulation of protein tyrosine kinase activity  signal transduction by p53 class mediator  negative regulation of monocyte chemotaxis  negative regulation of canonical Wnt signaling pathway  positive regulation of branching involved in ureteric bud morphogenesis  negative regulation of branching involved in ureteric bud morphogenesis  negative regulation of osteoclast proliferation  positive regulation of peptidyl-tyrosine autophosphorylation  negative regulation of bone trabecula formation  negative regulation of bone mineralization involved in bone maturation  positive regulation of receptor activity  positive regulation of cardiac muscle cell differentiation  
NDEx NetworkGREM1
Atlas of Cancer Signalling NetworkGREM1
Wikipedia pathwaysGREM1
Orthology - Evolution
OrthoDB26585
GeneTree (enSembl)ENSG00000166923
Phylogenetic Trees/Animal Genes : TreeFamGREM1
HOVERGENO60565
HOGENOMO60565
Homologs : HomoloGeneGREM1
Homology/Alignments : Family Browser (UCSC)GREM1
Gene fusions - Rearrangements
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerGREM1 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)GREM1
dbVarGREM1
ClinVarGREM1
1000_GenomesGREM1 
Exome Variant ServerGREM1
ExAC (Exome Aggregation Consortium)GREM1 (select the gene name)
Genetic variants : HAPMAP26585
Genomic Variants (DGV)GREM1 [DGVbeta]
DECIPHERGREM1 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisGREM1 
Mutations
ICGC Data PortalGREM1 
TCGA Data PortalGREM1 
Broad Tumor PortalGREM1
OASIS PortalGREM1 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICGREM1  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDGREM1
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch GREM1
DgiDB (Drug Gene Interaction Database)GREM1
DoCM (Curated mutations)GREM1 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)GREM1 (select a term)
intoGenGREM1
Cancer3DGREM1(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM603054   
Orphanet17145   
MedgenGREM1
Genetic Testing Registry GREM1
NextProtO60565 [Medical]
TSGene26585
GENETestsGREM1
Target ValidationGREM1
Huge Navigator GREM1 [HugePedia]
snp3D : Map Gene to Disease26585
BioCentury BCIQGREM1
ClinGenGREM1
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD26585
Chemical/Pharm GKB GenePA26537
Clinical trialGREM1
Miscellaneous
canSAR (ICR)GREM1 (select the gene name)
Probes
Litterature
PubMed96 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineGREM1
EVEXGREM1
GoPubMedGREM1
iHOPGREM1
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

Search in all EBI   NCBI

© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Wed Jun 7 12:35:58 CEST 2017

Home   Genes   Leukemias   Solid Tumors   Cancer-Prone   Deep Insight   Case Reports   Journals  Portal   Teaching   

For comments and suggestions or contributions, please contact us

jlhuret@AtlasGeneticsOncology.org.