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GREM2 (gremlin 2, DAN family BMP antagonist)

Identity

Alias_namesgremlin 2, cysteine knot superfamily, homolog (Xenopus laevis)
gremlin 2
Alias_symbol (synonym)Prdc
FLJ21195
CKTSF1B2
DAND3
Other aliasPRDC
HGNC (Hugo) GREM2
LocusID (NCBI) 64388
Atlas_Id 64033
Location 1q43  [Link to chromosome band 1q43]
Location_base_pair Starts at 240652873 and ends at 240775462 bp from pter ( according to hg19-Feb_2009)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)GREM2   17655
Cards
Entrez_Gene (NCBI)GREM2  64388  gremlin 2, DAN family BMP antagonist
AliasesCKTSF1B2; DAND3; PRDC
GeneCards (Weizmann)GREM2
Ensembl hg19 (Hinxton)ENSG00000180875 [Gene_View]  chr1:240652873-240775462 [Contig_View]  GREM2 [Vega]
Ensembl hg38 (Hinxton)ENSG00000180875 [Gene_View]  chr1:240652873-240775462 [Contig_View]  GREM2 [Vega]
ICGC DataPortalENSG00000180875
TCGA cBioPortalGREM2
AceView (NCBI)GREM2
Genatlas (Paris)GREM2
WikiGenes64388
SOURCE (Princeton)GREM2
Genetics Home Reference (NIH)GREM2
Genomic and cartography
GoldenPath hg19 (UCSC)GREM2  -     chr1:240652873-240775462 -  1q43   [Description]    (hg19-Feb_2009)
GoldenPath hg38 (UCSC)GREM2  -     1q43   [Description]    (hg38-Dec_2013)
EnsemblGREM2 - 1q43 [CytoView hg19]  GREM2 - 1q43 [CytoView hg38]
Mapping of homologs : NCBIGREM2 [Mapview hg19]  GREM2 [Mapview hg38]
OMIM608832   
Gene and transcription
Genbank (Entrez)AK024848 BC046632 BQ005641
RefSeq transcript (Entrez)NM_022469
RefSeq genomic (Entrez)NC_000001 NC_018912 NT_167186 NW_004929294
Consensus coding sequences : CCDS (NCBI)GREM2
Cluster EST : UnigeneHs.98206 [ NCBI ]
CGAP (NCI)Hs.98206
Alternative Splicing GalleryENSG00000180875
Gene ExpressionGREM2 [ NCBI-GEO ]   GREM2 [ EBI - ARRAY_EXPRESS ]   GREM2 [ SEEK ]   GREM2 [ MEM ]
Gene Expression Viewer (FireBrowse)GREM2 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)64388
GTEX Portal (Tissue expression)GREM2
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ9H772   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ9H772  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ9H772
Splice isoforms : SwissVarQ9H772
PhosPhoSitePlusQ9H772
Domaine pattern : Prosite (Expaxy)CTCK_2 (PS01225)   
Domains : Interpro (EBI)Cys_knot_C    DAN    Gremlin-1/2   
Domain families : Pfam (Sanger)DAN (PF03045)   
Domain families : Pfam (NCBI)pfam03045   
Domain families : Smart (EMBL)CT (SM00041)  
Conserved Domain (NCBI)GREM2
DMDM Disease mutations64388
Blocks (Seattle)GREM2
SuperfamilyQ9H772
Human Protein AtlasENSG00000180875
Peptide AtlasQ9H772
HPRD16390
IPIIPI00328709   
Protein Interaction databases
DIP (DOE-UCLA)Q9H772
IntAct (EBI)Q9H772
FunCoupENSG00000180875
BioGRIDGREM2
STRING (EMBL)GREM2
ZODIACGREM2
Ontologies - Pathways
QuickGOQ9H772
Ontology : AmiGOcytokine activity  extracellular region  extracellular space  heparin binding  embryonic body morphogenesis  cytokine-mediated signaling pathway  BMP signaling pathway  BMP binding  sequestering of BMP from receptor via BMP binding  protein homodimerization activity  determination of dorsal identity  regulation of cytokine activity  
Ontology : EGO-EBIcytokine activity  extracellular region  extracellular space  heparin binding  embryonic body morphogenesis  cytokine-mediated signaling pathway  BMP signaling pathway  BMP binding  sequestering of BMP from receptor via BMP binding  protein homodimerization activity  determination of dorsal identity  regulation of cytokine activity  
NDEx NetworkGREM2
Atlas of Cancer Signalling NetworkGREM2
Wikipedia pathwaysGREM2
Orthology - Evolution
OrthoDB64388
GeneTree (enSembl)ENSG00000180875
Phylogenetic Trees/Animal Genes : TreeFamGREM2
HOVERGENQ9H772
HOGENOMQ9H772
Homologs : HomoloGeneGREM2
Homology/Alignments : Family Browser (UCSC)GREM2
Gene fusions - Rearrangements
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerGREM2 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)GREM2
dbVarGREM2
ClinVarGREM2
1000_GenomesGREM2 
Exome Variant ServerGREM2
ExAC (Exome Aggregation Consortium)GREM2 (select the gene name)
Genetic variants : HAPMAP64388
Genomic Variants (DGV)GREM2 [DGVbeta]
DECIPHER (Syndromes)1:240652873-240775462  ENSG00000180875
CONAN: Copy Number AnalysisGREM2 
Mutations
ICGC Data PortalGREM2 
TCGA Data PortalGREM2 
Broad Tumor PortalGREM2
OASIS PortalGREM2 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICGREM2  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDGREM2
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch GREM2
DgiDB (Drug Gene Interaction Database)GREM2
DoCM (Curated mutations)GREM2 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)GREM2 (select a term)
intoGenGREM2
Cancer3DGREM2(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM608832   
Orphanet
MedgenGREM2
Genetic Testing Registry GREM2
NextProtQ9H772 [Medical]
TSGene64388
GENETestsGREM2
Huge Navigator GREM2 [HugePedia]
snp3D : Map Gene to Disease64388
BioCentury BCIQGREM2
ClinGenGREM2
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD64388
Chemical/Pharm GKB GenePA134968998
Clinical trialGREM2
Miscellaneous
canSAR (ICR)GREM2 (select the gene name)
Probes
Litterature
PubMed16 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineGREM2
EVEXGREM2
GoPubMedGREM2
iHOPGREM2
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

Search in all EBI   NCBI

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indexed on : Tue Mar 14 12:06:53 CET 2017

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