Atlas of Genetics and Cytogenetics in Oncology and Haematology


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GRHL3 (grainyhead like transcription factor 3)

Identity

Alias (NCBI)SOM
TFCP2L4
VWS2
HGNC (Hugo) GRHL3
HGNC Alias symbSOM
HGNC Alias namesister-of-mammalian grainyhead
HGNC Previous nameTFCP2L4
HGNC Previous nametranscription factor CP2-like 4
 grainyhead-like 3 (Drosophila)
LocusID (NCBI) 57822
Atlas_Id 50516
Location 1p36.11  [Link to chromosome band 1p36]
Location_base_pair Starts at 24319357 and ends at 24364480 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
CLIC4 (1p36.11) / GRHL3 (1p36.11)SLC2A1 (1p34.2) / GRHL3 (1p36.11)CLIC4 1p36.11 / GRHL3 1p36.11
SLC2A1 1p34.2 / GRHL3 1p36.11

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 



External links

 

Nomenclature
HGNC (Hugo)GRHL3   25839
Cards
Entrez_Gene (NCBI)GRHL3    grainyhead like transcription factor 3
AliasesSOM; TFCP2L4; VWS2
GeneCards (Weizmann)GRHL3
Ensembl hg19 (Hinxton)ENSG00000158055 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000158055 [Gene_View]  ENSG00000158055 [Sequence]  chr1:24319357-24364480 [Contig_View]  GRHL3 [Vega]
ICGC DataPortalENSG00000158055
TCGA cBioPortalGRHL3
AceView (NCBI)GRHL3
Genatlas (Paris)GRHL3
SOURCE (Princeton)GRHL3
Genetics Home Reference (NIH)GRHL3
Genomic and cartography
GoldenPath hg38 (UCSC)GRHL3  -     chr1:24319357-24364480 +  1p36.11   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)GRHL3  -     1p36.11   [Description]    (hg19-Feb_2009)
GoldenPathGRHL3 - 1p36.11 [CytoView hg19]  GRHL3 - 1p36.11 [CytoView hg38]
ImmunoBaseENSG00000158055
Genome Data Viewer NCBIGRHL3 [Mapview hg19]  
OMIM606713   608317   
Gene and transcription
Genbank (Entrez)AK074386 AK315164 AL137763 AY231160 AY231161
RefSeq transcript (Entrez)NM_001195010 NM_021180 NM_198173 NM_198174
Consensus coding sequences : CCDS (NCBI)GRHL3
Gene ExpressionGRHL3 [ NCBI-GEO ]   GRHL3 [ EBI - ARRAY_EXPRESS ]   GRHL3 [ SEEK ]   GRHL3 [ MEM ]
Gene Expression Viewer (FireBrowse)GRHL3 [ Firebrowse - Broad ]
GenevisibleExpression of GRHL3 in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)57822
GTEX Portal (Tissue expression)GRHL3
Human Protein AtlasENSG00000158055-GRHL3 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ8TE85   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ8TE85  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ8TE85
PhosPhoSitePlusQ8TE85
Domains : Interpro (EBI)CP2   
Domain families : Pfam (Sanger)CP2 (PF04516)   
Domain families : Pfam (NCBI)pfam04516   
Conserved Domain (NCBI)GRHL3
SuperfamilyQ8TE85
AlphaFold pdb e-kbQ8TE85   
Human Protein Atlas [tissue]ENSG00000158055-GRHL3 [tissue]
HPRD12210
Protein Interaction databases
DIP (DOE-UCLA)Q8TE85
IntAct (EBI)Q8TE85
BioGRIDGRHL3
STRING (EMBL)GRHL3
ZODIACGRHL3
Ontologies - Pathways
QuickGOQ8TE85
Ontology : AmiGOchromatin  RNA polymerase II cis-regulatory region sequence-specific DNA binding  DNA-binding transcription factor activity, RNA polymerase II-specific  DNA-binding transcription activator activity, RNA polymerase II-specific  DNA-binding transcription activator activity, RNA polymerase II-specific  establishment of planar polarity  neural tube closure  protein binding  nucleus  nucleus  nucleoplasm  regulation of transcription by RNA polymerase II  pattern specification process  ectoderm development  central nervous system development  epidermis development  positive regulation of gene expression  chromatin DNA binding  regulation of actin cytoskeleton organization  wound healing  positive regulation of GTPase activity  sequence-specific DNA binding  positive regulation of transcription by RNA polymerase II  eyelid development in camera-type eye  establishment of skin barrier  cochlea morphogenesis  planar cell polarity pathway involved in neural tube closure  
Ontology : EGO-EBIchromatin  RNA polymerase II cis-regulatory region sequence-specific DNA binding  DNA-binding transcription factor activity, RNA polymerase II-specific  DNA-binding transcription activator activity, RNA polymerase II-specific  DNA-binding transcription activator activity, RNA polymerase II-specific  establishment of planar polarity  neural tube closure  protein binding  nucleus  nucleus  nucleoplasm  regulation of transcription by RNA polymerase II  pattern specification process  ectoderm development  central nervous system development  epidermis development  positive regulation of gene expression  chromatin DNA binding  regulation of actin cytoskeleton organization  wound healing  positive regulation of GTPase activity  sequence-specific DNA binding  positive regulation of transcription by RNA polymerase II  eyelid development in camera-type eye  establishment of skin barrier  cochlea morphogenesis  planar cell polarity pathway involved in neural tube closure  
NDEx NetworkGRHL3
Atlas of Cancer Signalling NetworkGRHL3
Wikipedia pathwaysGRHL3
Orthology - Evolution
OrthoDB57822
GeneTree (enSembl)ENSG00000158055
Phylogenetic Trees/Animal Genes : TreeFamGRHL3
Homologs : HomoloGeneGRHL3
Homology/Alignments : Family Browser (UCSC)GRHL3
Gene fusions - Rearrangements
Fusion : MitelmanCLIC4/GRHL3 [1p36.11/1p36.11]  
Fusion : MitelmanSLC2A1/GRHL3 [1p34.2/1p36.11]  
Fusion : QuiverGRHL3
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerGRHL3 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)GRHL3
dbVarGRHL3
ClinVarGRHL3
MonarchGRHL3
1000_GenomesGRHL3 
Exome Variant ServerGRHL3
GNOMAD BrowserENSG00000158055
Varsome BrowserGRHL3
ACMGGRHL3 variants
VarityQ8TE85
Genomic Variants (DGV)GRHL3 [DGVbeta]
DECIPHERGRHL3 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisGRHL3 
Mutations
ICGC Data PortalGRHL3 
TCGA Data PortalGRHL3 
Broad Tumor PortalGRHL3
OASIS PortalGRHL3 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICGRHL3  [overview]  [genome browser]  [tissue]  [distribution]  
Somatic Mutations in Cancer : COSMIC3DGRHL3
Mutations and Diseases : HGMDGRHL3
LOVD (Leiden Open Variation Database)[gene] [transcripts] [variants]
BioMutaGRHL3
DgiDB (Drug Gene Interaction Database)GRHL3
DoCM (Curated mutations)GRHL3
CIViC (Clinical Interpretations of Variants in Cancer)GRHL3
Cancer3DGRHL3
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM606713    608317   
Orphanet967   
DisGeNETGRHL3
MedgenGRHL3
Genetic Testing Registry GRHL3
NextProtQ8TE85 [Medical]
GENETestsGRHL3
Target ValidationGRHL3
Huge Navigator GRHL3 [HugePedia]
ClinGenGRHL3
Clinical trials, drugs, therapy
MyCancerGenomeGRHL3
Protein Interactions : CTDGRHL3
Pharm GKB GenePA134987320
PharosQ8TE85
Clinical trialGRHL3
Miscellaneous
canSAR (ICR)GRHL3
HarmonizomeGRHL3
DataMed IndexGRHL3
Probes
Litterature
PubMed44 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
EVEXGRHL3
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Mon Oct 4 15:11:29 CEST 2021

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