Atlas of Genetics and Cytogenetics in Oncology and Haematology


Home   Genes   Leukemias   Solid Tumors   Cancer-Prone   Deep Insight   Case Reports   Journals  Portal   Teaching   

X Y 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 NA

GRHL3 (grainyhead like transcription factor 3)

Identity

Alias_namesTFCP2L4
transcription factor CP2-like 4
grainyhead-like 3 (Drosophila)
Alias_symbol (synonym)SOM
Other aliasVWS2
HGNC (Hugo) GRHL3
LocusID (NCBI) 57822
Atlas_Id 50516
Location 1p36.11  [Link to chromosome band 1p36]
Location_base_pair Starts at 24319566 and ends at 24355318 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2016)
CLIC4 (1p36.11) / GRHL3 (1p36.11)SLC2A1 (1p34.2) / GRHL3 (1p36.11)CLIC4 1p36.11 / GRHL3 1p36.11
SLC2A1 1p34.2 / GRHL3 1p36.11

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)GRHL3   25839
Cards
Entrez_Gene (NCBI)GRHL3  57822  grainyhead like transcription factor 3
AliasesSOM; TFCP2L4; VWS2
GeneCards (Weizmann)GRHL3
Ensembl hg19 (Hinxton)ENSG00000158055 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000158055 [Gene_View]  chr1:24319566-24355318 [Contig_View]  GRHL3 [Vega]
ICGC DataPortalENSG00000158055
TCGA cBioPortalGRHL3
AceView (NCBI)GRHL3
Genatlas (Paris)GRHL3
WikiGenes57822
SOURCE (Princeton)GRHL3
Genetics Home Reference (NIH)GRHL3
Genomic and cartography
GoldenPath hg38 (UCSC)GRHL3  -     chr1:24319566-24355318 +  1p36.11   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)GRHL3  -     1p36.11   [Description]    (hg19-Feb_2009)
EnsemblGRHL3 - 1p36.11 [CytoView hg19]  GRHL3 - 1p36.11 [CytoView hg38]
Mapping of homologs : NCBIGRHL3 [Mapview hg19]  GRHL3 [Mapview hg38]
OMIM606713   608317   
Gene and transcription
Genbank (Entrez)AK074386 AK315164 AL137763 AY231160 AY231161
RefSeq transcript (Entrez)NM_001195010 NM_021180 NM_198173 NM_198174
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)GRHL3
Cluster EST : UnigeneHs.657920 [ NCBI ]
CGAP (NCI)Hs.657920
Alternative Splicing GalleryENSG00000158055
Gene ExpressionGRHL3 [ NCBI-GEO ]   GRHL3 [ EBI - ARRAY_EXPRESS ]   GRHL3 [ SEEK ]   GRHL3 [ MEM ]
Gene Expression Viewer (FireBrowse)GRHL3 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)57822
GTEX Portal (Tissue expression)GRHL3
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ8TE85   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ8TE85  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ8TE85
Splice isoforms : SwissVarQ8TE85
PhosPhoSitePlusQ8TE85
Domains : Interpro (EBI)CP2   
Domain families : Pfam (Sanger)CP2 (PF04516)   
Domain families : Pfam (NCBI)pfam04516   
Conserved Domain (NCBI)GRHL3
DMDM Disease mutations57822
Blocks (Seattle)GRHL3
SuperfamilyQ8TE85
Human Protein AtlasENSG00000158055
Peptide AtlasQ8TE85
HPRD12210
IPIIPI00152668   IPI00375532   IPI00377073   IPI00983521   IPI00414555   IPI01009876   IPI00976843   
Protein Interaction databases
DIP (DOE-UCLA)Q8TE85
IntAct (EBI)Q8TE85
FunCoupENSG00000158055
BioGRIDGRHL3
STRING (EMBL)GRHL3
ZODIACGRHL3
Ontologies - Pathways
QuickGOQ8TE85
Ontology : AmiGOtranscriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding  establishment of planar polarity  neural tube closure  protein binding  nucleus  nucleoplasm  transcription from RNA polymerase II promoter  pattern specification process  ectoderm development  central nervous system development  epidermis development  chromatin DNA binding  regulation of actin cytoskeleton organization  wound healing  positive regulation of GTPase activity  sequence-specific DNA binding  positive regulation of transcription from RNA polymerase II promoter  eyelid development in camera-type eye  establishment of skin barrier  cochlea morphogenesis  planar cell polarity pathway involved in neural tube closure  
Ontology : EGO-EBItranscriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding  establishment of planar polarity  neural tube closure  protein binding  nucleus  nucleoplasm  transcription from RNA polymerase II promoter  pattern specification process  ectoderm development  central nervous system development  epidermis development  chromatin DNA binding  regulation of actin cytoskeleton organization  wound healing  positive regulation of GTPase activity  sequence-specific DNA binding  positive regulation of transcription from RNA polymerase II promoter  eyelid development in camera-type eye  establishment of skin barrier  cochlea morphogenesis  planar cell polarity pathway involved in neural tube closure  
NDEx NetworkGRHL3
Atlas of Cancer Signalling NetworkGRHL3
Wikipedia pathwaysGRHL3
Orthology - Evolution
OrthoDB57822
GeneTree (enSembl)ENSG00000158055
Phylogenetic Trees/Animal Genes : TreeFamGRHL3
HOVERGENQ8TE85
HOGENOMQ8TE85
Homologs : HomoloGeneGRHL3
Homology/Alignments : Family Browser (UCSC)GRHL3
Gene fusions - Rearrangements
Fusion : MitelmanCLIC4/GRHL3 [1p36.11/1p36.11]  [t(1;1)(p36;p36)]  
Fusion : MitelmanSLC2A1/GRHL3 [1p34.2/1p36.11]  [t(1;1)(p34;p36)]  
Fusion: TCGACLIC4 1p36.11 GRHL3 1p36.11 LUAD
Fusion: TCGASLC2A1 1p34.2 GRHL3 1p36.11 BRCA
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerGRHL3 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)GRHL3
dbVarGRHL3
ClinVarGRHL3
1000_GenomesGRHL3 
Exome Variant ServerGRHL3
ExAC (Exome Aggregation Consortium)GRHL3 (select the gene name)
Genetic variants : HAPMAP57822
Genomic Variants (DGV)GRHL3 [DGVbeta]
DECIPHERGRHL3 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisGRHL3 
Mutations
ICGC Data PortalGRHL3 
TCGA Data PortalGRHL3 
Broad Tumor PortalGRHL3
OASIS PortalGRHL3 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICGRHL3  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDGRHL3
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch GRHL3
DgiDB (Drug Gene Interaction Database)GRHL3
DoCM (Curated mutations)GRHL3 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)GRHL3 (select a term)
intoGenGRHL3
Cancer3DGRHL3(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM606713    608317   
Orphanet967   
MedgenGRHL3
Genetic Testing Registry GRHL3
NextProtQ8TE85 [Medical]
TSGene57822
GENETestsGRHL3
Huge Navigator GRHL3 [HugePedia]
snp3D : Map Gene to Disease57822
BioCentury BCIQGRHL3
ClinGenGRHL3
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD57822
Chemical/Pharm GKB GenePA134987320
Clinical trialGRHL3
Miscellaneous
canSAR (ICR)GRHL3 (select the gene name)
Probes
Litterature
PubMed25 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineGRHL3
EVEXGRHL3
GoPubMedGRHL3
iHOPGRHL3
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

Search in all EBI   NCBI

© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Fri May 19 12:17:57 CEST 2017

Home   Genes   Leukemias   Solid Tumors   Cancer-Prone   Deep Insight   Case Reports   Journals  Portal   Teaching   

For comments and suggestions or contributions, please contact us

jlhuret@AtlasGeneticsOncology.org.