Atlas of Genetics and Cytogenetics in Oncology and Haematology


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GRHPR (glyoxylate reductase/hydroxypyruvate reductase)

Identity

Alias_namesGLXR
glyoxylate reductase/hydroxypyruvate reductase
glyoxylate reductase and hydroxypyruvate reductase
Alias_symbol (synonym)PH2
HGNC (Hugo) GRHPR
LocusID (NCBI) 9380
Atlas_Id 44026
Location 9p13.2  [Link to chromosome band 9p13]
Location_base_pair Starts at 37422707 and ends at 37436986 bp from pter ( according to hg19-Feb_2009)
Fusion genes
(updated 2016)
GRHPR (9p13.2) / BCL6 (3q27.3)GRHPR (9p13.2) / C3 (19p13.3)GRHPR (9p13.2) / DVL2 (17p13.1)
GRHPR (9p13.2) / LCLAT1 (2p23.1)GRHPR (9p13.2) / PNO1 (2p14)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


Other Leukemias implicated (Data extracted from papers in the Atlas) [ 1 ]
  t(3;9)(q27;p13) GRHPR/BCL6


External links

Nomenclature
HGNC (Hugo)GRHPR   4570
Cards
Entrez_Gene (NCBI)GRHPR  9380  glyoxylate reductase/hydroxypyruvate reductase
AliasesGLXR; GLYD; PH2
GeneCards (Weizmann)GRHPR
Ensembl hg19 (Hinxton)ENSG00000137106 [Gene_View]  chr9:37422707-37436986 [Contig_View]  GRHPR [Vega]
Ensembl hg38 (Hinxton)ENSG00000137106 [Gene_View]  chr9:37422707-37436986 [Contig_View]  GRHPR [Vega]
ICGC DataPortalENSG00000137106
TCGA cBioPortalGRHPR
AceView (NCBI)GRHPR
Genatlas (Paris)GRHPR
WikiGenes9380
SOURCE (Princeton)GRHPR
Genetics Home Reference (NIH)GRHPR
Genomic and cartography
GoldenPath hg19 (UCSC)GRHPR  -     chr9:37422707-37436986 +  9p13.2   [Description]    (hg19-Feb_2009)
GoldenPath hg38 (UCSC)GRHPR  -     9p13.2   [Description]    (hg38-Dec_2013)
EnsemblGRHPR - 9p13.2 [CytoView hg19]  GRHPR - 9p13.2 [CytoView hg38]
Mapping of homologs : NCBIGRHPR [Mapview hg19]  GRHPR [Mapview hg38]
OMIM260000   604296   
Gene and transcription
Genbank (Entrez)AF113215 AF113251 AF134895 AF146018 AK024386
RefSeq transcript (Entrez)NM_012203
RefSeq genomic (Entrez)NC_000009 NC_018920 NG_008135 NT_008413 NW_004929342
Consensus coding sequences : CCDS (NCBI)GRHPR
Cluster EST : UnigeneHs.155742 [ NCBI ]
CGAP (NCI)Hs.155742
Alternative Splicing GalleryENSG00000137106
Gene ExpressionGRHPR [ NCBI-GEO ]   GRHPR [ EBI - ARRAY_EXPRESS ]   GRHPR [ SEEK ]   GRHPR [ MEM ]
Gene Expression Viewer (FireBrowse)GRHPR [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)9380
GTEX Portal (Tissue expression)GRHPR
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ9UBQ7   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ9UBQ7  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ9UBQ7
Splice isoforms : SwissVarQ9UBQ7
Catalytic activity : Enzyme1.1.1.79 [ Enzyme-Expasy ]   1.1.1.791.1.1.79 [ IntEnz-EBI ]   1.1.1.79 [ BRENDA ]   1.1.1.79 [ KEGG ]   
PhosPhoSitePlusQ9UBQ7
Domaine pattern : Prosite (Expaxy)D_2_HYDROXYACID_DH_3 (PS00671)   
Domains : Interpro (EBI)D-isomer_2_OHA_DH_cat_dom    D-isomer_DH_CS    D-isomer_DH_NAD-bd    NAD(P)-bd_dom   
Domain families : Pfam (Sanger)2-Hacid_dh (PF00389)    2-Hacid_dh_C (PF02826)   
Domain families : Pfam (NCBI)pfam00389    pfam02826   
Conserved Domain (NCBI)GRHPR
DMDM Disease mutations9380
Blocks (Seattle)GRHPR
PDB (SRS)2GCG    2H1S    2Q50    2WWR   
PDB (PDBSum)2GCG    2H1S    2Q50    2WWR   
PDB (IMB)2GCG    2H1S    2Q50    2WWR   
PDB (RSDB)2GCG    2H1S    2Q50    2WWR   
Structural Biology KnowledgeBase2GCG    2H1S    2Q50    2WWR   
SCOP (Structural Classification of Proteins)2GCG    2H1S    2Q50    2WWR   
CATH (Classification of proteins structures)2GCG    2H1S    2Q50    2WWR   
SuperfamilyQ9UBQ7
Human Protein AtlasENSG00000137106
Peptide AtlasQ9UBQ7
HPRD05052
IPIIPI00037448   IPI00550682   IPI00514020   IPI00026486   
Protein Interaction databases
DIP (DOE-UCLA)Q9UBQ7
IntAct (EBI)Q9UBQ7
FunCoupENSG00000137106
BioGRIDGRHPR
STRING (EMBL)GRHPR
ZODIACGRHPR
Ontologies - Pathways
QuickGOQ9UBQ7
Ontology : AmiGOcytoplasm  peroxisomal matrix  cytosol  excretion  metabolic process  glycerate dehydrogenase activity  hydroxypyruvate reductase activity  glyoxylate reductase (NADP) activity  glyoxylate reductase (NADP) activity  glyoxylate reductase (NADP) activity  carboxylic acid binding  protein homodimerization activity  dicarboxylic acid metabolic process  glyoxylate metabolic process  protein oligomerization  NAD binding  oxidation-reduction process  extracellular exosome  NADPH binding  
Ontology : EGO-EBIcytoplasm  peroxisomal matrix  cytosol  excretion  metabolic process  glycerate dehydrogenase activity  hydroxypyruvate reductase activity  glyoxylate reductase (NADP) activity  glyoxylate reductase (NADP) activity  glyoxylate reductase (NADP) activity  carboxylic acid binding  protein homodimerization activity  dicarboxylic acid metabolic process  glyoxylate metabolic process  protein oligomerization  NAD binding  oxidation-reduction process  extracellular exosome  NADPH binding  
Pathways : KEGGGlycine, serine and threonine metabolism    Pyruvate metabolism    Glyoxylate and dicarboxylate metabolism   
NDEx NetworkGRHPR
Atlas of Cancer Signalling NetworkGRHPR
Wikipedia pathwaysGRHPR
Orthology - Evolution
OrthoDB9380
GeneTree (enSembl)ENSG00000137106
Phylogenetic Trees/Animal Genes : TreeFamGRHPR
HOVERGENQ9UBQ7
HOGENOMQ9UBQ7
Homologs : HomoloGeneGRHPR
Homology/Alignments : Family Browser (UCSC)GRHPR
Gene fusions - Rearrangements
Fusion : MitelmanGRHPR/BCL6 [9p13.2/3q27.3]  
Fusion : MitelmanGRHPR/C3 [9p13.2/19p13.3]  [t(9;19)(p13;p13)]  
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerGRHPR [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)GRHPR
dbVarGRHPR
ClinVarGRHPR
1000_GenomesGRHPR 
Exome Variant ServerGRHPR
ExAC (Exome Aggregation Consortium)GRHPR (select the gene name)
Genetic variants : HAPMAP9380
Genomic Variants (DGV)GRHPR [DGVbeta]
DECIPHER (Syndromes)9:37422707-37436986  ENSG00000137106
CONAN: Copy Number AnalysisGRHPR 
Mutations
ICGC Data PortalGRHPR 
TCGA Data PortalGRHPR 
Broad Tumor PortalGRHPR
OASIS PortalGRHPR [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICGRHPR  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDGRHPR
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch GRHPR
DgiDB (Drug Gene Interaction Database)GRHPR
DoCM (Curated mutations)GRHPR (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)GRHPR (select a term)
intoGenGRHPR
Cancer3DGRHPR(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM260000    604296   
Orphanet12432   
MedgenGRHPR
Genetic Testing Registry GRHPR
NextProtQ9UBQ7 [Medical]
TSGene9380
GENETestsGRHPR
Huge Navigator GRHPR [HugePedia]
snp3D : Map Gene to Disease9380
BioCentury BCIQGRHPR
ClinGenGRHPR
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD9380
Chemical/Pharm GKB GenePA28965
Clinical trialGRHPR
Miscellaneous
canSAR (ICR)GRHPR (select the gene name)
Probes
Litterature
PubMed30 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineGRHPR
EVEXGRHPR
GoPubMedGRHPR
iHOPGRHPR
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Fri Nov 18 19:38:48 CET 2016

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