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GRHPR (glyoxylate reductase/hydroxypyruvate reductase)

Identity

Other namesGLXR
GLYD
PH2
HGNC (Hugo) GRHPR
LocusID (NCBI) 9380
Location 9p13.2
Location_base_pair Starts at 37422707 and ends at 37436986 bp from pter ( according to hg19-Feb_2009)
Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 

Other Leukemias implicated (Data extracted from papers in the Atlas)

Leukemias 11q23ChildAMLID1615

External links

Nomenclature
HGNC (Hugo)GRHPR   4570
Cards
Entrez_Gene (NCBI)GRHPR  9380  glyoxylate reductase/hydroxypyruvate reductase
GeneCards (Weizmann)GRHPR
Ensembl hg19 (Hinxton)ENSG00000137106 [Gene_View]  chr9:37422707-37436986 [Contig_View]  GRHPR [Vega]
Ensembl hg38 (Hinxton)ENSG00000137106 [Gene_View]  chr9:37422707-37436986 [Contig_View]  GRHPR [Vega]
ICGC DataPortalENSG00000137106
cBioPortalGRHPR
AceView (NCBI)GRHPR
Genatlas (Paris)GRHPR
WikiGenes9380
SOURCE (Princeton)GRHPR
Genomic and cartography
GoldenPath hg19 (UCSC)GRHPR  -     chr9:37422707-37436986 +  9p13.2   [Description]    (hg19-Feb_2009)
GoldenPath hg38 (UCSC)GRHPR  -     9p13.2   [Description]    (hg38-Dec_2013)
EnsemblGRHPR - 9p13.2 [CytoView hg19]  GRHPR - 9p13.2 [CytoView hg38]
Mapping of homologs : NCBIGRHPR [Mapview hg19]  GRHPR [Mapview hg38]
OMIM260000   604296   
Gene and transcription
Genbank (Entrez)AF113215 AF113251 AF134895 AF146018 AK024386
RefSeq transcript (Entrez)NM_012203
RefSeq genomic (Entrez)AC_000141 NC_000009 NC_018920 NG_008135 NT_008413 NW_001839151 NW_004929342
Consensus coding sequences : CCDS (NCBI)GRHPR
Cluster EST : UnigeneHs.155742 [ NCBI ]
CGAP (NCI)Hs.155742
Alternative Splicing : Fast-db (Paris)GSHG0030123
Alternative Splicing GalleryENSG00000137106
Gene ExpressionGRHPR [ NCBI-GEO ]     GRHPR [ SEEK ]   GRHPR [ MEM ]
SOURCE (Princeton)Expression in : [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ9UBQ7 (Uniprot)
NextProtQ9UBQ7  [Medical]
With graphics : InterProQ9UBQ7
Splice isoforms : SwissVarQ9UBQ7 (Swissvar)
Catalytic activity : Enzyme1.1.1.79 [ Enzyme-Expasy ]   1.1.1.791.1.1.79 [ IntEnz-EBI ]   1.1.1.79 [ BRENDA ]   1.1.1.79 [ KEGG ]   
Domaine pattern : Prosite (Expaxy)D_2_HYDROXYACID_DH_3 (PS00671)   
Domains : Interpro (EBI)D-isomer_2_OHA_DH_cat_dom    D-isomer_2_OHA_DH_NAD-bd    NAD(P)-bd_dom   
Related proteins : CluSTrQ9UBQ7
Domain families : Pfam (Sanger)2-Hacid_dh (PF00389)    2-Hacid_dh_C (PF02826)   
Domain families : Pfam (NCBI)pfam00389    pfam02826   
DMDM Disease mutations9380
Blocks (Seattle)Q9UBQ7
PDB (SRS)2GCG    2H1S    2Q50    2WWR   
PDB (PDBSum)2GCG    2H1S    2Q50    2WWR   
PDB (IMB)2GCG    2H1S    2Q50    2WWR   
PDB (RSDB)2GCG    2H1S    2Q50    2WWR   
Human Protein AtlasENSG00000137106
Peptide AtlasQ9UBQ7
HPRD05052
IPIIPI00037448   IPI00550682   IPI00514020   IPI00026486   
Protein Interaction databases
DIP (DOE-UCLA)Q9UBQ7
IntAct (EBI)Q9UBQ7
FunCoupENSG00000137106
BioGRIDGRHPR
IntegromeDBGRHPR
STRING (EMBL)GRHPR
Ontologies - Pathways
QuickGOQ9UBQ7
Ontology : AmiGOcytoplasm  peroxisomal matrix  cytosol  excretion  metabolic process  glycerate dehydrogenase activity  hydroxypyruvate reductase activity  glyoxylate reductase (NADP) activity  glyoxylate reductase (NADP) activity  carboxylic acid binding  cellular nitrogen compound metabolic process  protein homodimerization activity  dicarboxylic acid metabolic process  small molecule metabolic process  glyoxylate metabolic process  protein oligomerization  NAD binding  oxidation-reduction process  extracellular vesicular exosome  NADPH binding  
Ontology : EGO-EBIcytoplasm  peroxisomal matrix  cytosol  excretion  metabolic process  glycerate dehydrogenase activity  hydroxypyruvate reductase activity  glyoxylate reductase (NADP) activity  glyoxylate reductase (NADP) activity  carboxylic acid binding  cellular nitrogen compound metabolic process  protein homodimerization activity  dicarboxylic acid metabolic process  small molecule metabolic process  glyoxylate metabolic process  protein oligomerization  NAD binding  oxidation-reduction process  extracellular vesicular exosome  NADPH binding  
Pathways : KEGGGlycine, serine and threonine metabolism    Pyruvate metabolism    Glyoxylate and dicarboxylate metabolism   
Protein Interaction DatabaseGRHPR
DoCM (Curated mutations)GRHPR
Wikipedia pathwaysGRHPR
Gene fusion - rearrangements
Polymorphisms : SNP, variants
NCBI Variation ViewerGRHPR [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)GRHPR
dbVarGRHPR
ClinVarGRHPR
1000_GenomesGRHPR 
Exome Variant ServerGRHPR
SNP (GeneSNP Utah)GRHPR
SNP : HGBaseGRHPR
Genetic variants : HAPMAPGRHPR
Genomic VariantsGRHPR  GRHPR [DGVbeta]
Mutations
ICGC Data PortalENSG00000137106 
Somatic Mutations in Cancer : COSMICGRHPR 
CONAN: Copy Number AnalysisGRHPR 
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] 
Diseases
DECIPHER (Syndromes)9:37422707-37436986
Mutations and Diseases : HGMDGRHPR
OMIM260000    604296   
MedgenGRHPR
NextProtQ9UBQ7 [Medical]
GENETestsGRHPR
Disease Genetic AssociationGRHPR
Huge Navigator GRHPR [HugePedia]  GRHPR [HugeCancerGEM]
snp3D : Map Gene to Disease9380
DGIdb (Drug Gene Interaction db)GRHPR
General knowledge
Homologs : HomoloGeneGRHPR
Homology/Alignments : Family Browser (UCSC)GRHPR
Phylogenetic Trees/Animal Genes : TreeFamGRHPR
Chemical/Protein Interactions : CTD9380
Chemical/Pharm GKB GenePA28965
Clinical trialGRHPR
Cancer Resource (Charite)ENSG00000137106
Other databases
Probes
Litterature
PubMed28 Pubmed reference(s) in Entrez
CoreMineGRHPR
GoPubMedGRHPR
iHOPGRHPR
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

Search in all EBI   NCBI

Contributor(s)

Written09-2002Dessen P, Le Minor S
Updated12-2014Dessen P

© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Sat Dec 20 21:53:00 CET 2014

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