Atlas of Genetics and Cytogenetics in Oncology and Haematology


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GRIA1 (glutamate ionotropic receptor AMPA type subunit 1)

Identity

Alias_namesGLUR1
glutamate receptor
Alias_symbol (synonym)GluA1
GLURA
Other aliasGLUH1
HBGR1
HGNC (Hugo) GRIA1
LocusID (NCBI) 2890
Atlas_Id 50538
Location 5q33.2  [Link to chromosome band 5q33]
Location_base_pair Starts at 153490524 and ends at 153813869 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2016)
GRIA1 (5q33.2) / GRIA1 (5q33.2)SQSTM1 (5q35.3) / GRIA1 (5q33.2)SQSTM1 5q35.3 / GRIA1 5q33.2

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)GRIA1   4571
Cards
Entrez_Gene (NCBI)GRIA1  2890  glutamate ionotropic receptor AMPA type subunit 1
AliasesGLUH1; GLUR1; GLURA; GluA1; 
HBGR1
GeneCards (Weizmann)GRIA1
Ensembl hg19 (Hinxton)ENSG00000155511 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000155511 [Gene_View]  chr5:153490524-153813869 [Contig_View]  GRIA1 [Vega]
ICGC DataPortalENSG00000155511
TCGA cBioPortalGRIA1
AceView (NCBI)GRIA1
Genatlas (Paris)GRIA1
WikiGenes2890
SOURCE (Princeton)GRIA1
Genetics Home Reference (NIH)GRIA1
Genomic and cartography
GoldenPath hg38 (UCSC)GRIA1  -     chr5:153490524-153813869 +  5q33.2   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)GRIA1  -     5q33.2   [Description]    (hg19-Feb_2009)
EnsemblGRIA1 - 5q33.2 [CytoView hg19]  GRIA1 - 5q33.2 [CytoView hg38]
Mapping of homologs : NCBIGRIA1 [Mapview hg19]  GRIA1 [Mapview hg38]
OMIM138248   
Gene and transcription
Genbank (Entrez)AB209094 AK289565 AK294011 AK294773 AK295039
RefSeq transcript (Entrez)NM_000827 NM_001114183 NM_001258019 NM_001258020 NM_001258021 NM_001258022 NM_001258023
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)GRIA1
Cluster EST : UnigeneHs.737709 [ NCBI ]
CGAP (NCI)Hs.737709
Alternative Splicing GalleryENSG00000155511
Gene ExpressionGRIA1 [ NCBI-GEO ]   GRIA1 [ EBI - ARRAY_EXPRESS ]   GRIA1 [ SEEK ]   GRIA1 [ MEM ]
Gene Expression Viewer (FireBrowse)GRIA1 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)2890
GTEX Portal (Tissue expression)GRIA1
Protein : pattern, domain, 3D structure
UniProt/SwissProtP42261   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtP42261  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProP42261
Splice isoforms : SwissVarP42261
PhosPhoSitePlusP42261
Domains : Interpro (EBI)ANF_lig-bd_rcpt    Glu/Gly-bd    Iono_rcpt_met    Iontro_rcpt    Peripla_BP_I   
Domain families : Pfam (Sanger)ANF_receptor (PF01094)    Lig_chan (PF00060)    Lig_chan-Glu_bd (PF10613)   
Domain families : Pfam (NCBI)pfam01094    pfam00060    pfam10613   
Domain families : Smart (EMBL)Lig_chan-Glu_bd (SM00918)  PBPe (SM00079)  
Conserved Domain (NCBI)GRIA1
DMDM Disease mutations2890
Blocks (Seattle)GRIA1
SuperfamilyP42261
Human Protein AtlasENSG00000155511
Peptide AtlasP42261
HPRD00695
IPIIPI00030880   IPI00219124   IPI00956375   IPI01014502   IPI00976787   IPI00978580   IPI00977433   
Protein Interaction databases
DIP (DOE-UCLA)P42261
IntAct (EBI)P42261
FunCoupENSG00000155511
BioGRIDGRIA1
STRING (EMBL)GRIA1
ZODIACGRIA1
Ontologies - Pathways
QuickGOP42261
Ontology : AmiGOGolgi membrane  AMPA glutamate receptor activity  excitatory extracellular ligand-gated ion channel activity  extracellular-glutamate-gated ion channel activity  protein binding  endoplasmic reticulum membrane  plasma membrane  ER to Golgi vesicle-mediated transport  signal transduction  chemical synaptic transmission  long-term memory  synaptic vesicle  glutamate receptor activity  cell surface  ER to Golgi transport vesicle membrane  postsynaptic density  cell junction  PDZ domain binding  dendrite  endocytic vesicle membrane  receptor internalization  AMPA glutamate receptor complex  AMPA glutamate receptor complex  dendritic spine membrane  endoplasmic reticulum-Golgi intermediate compartment membrane  ion transmembrane transport  ionotropic glutamate receptor signaling pathway  neuronal cell body  dendritic spine  axonal spine  neuron spine  COPII vesicle coating  recycling endosome  excitatory postsynaptic potential  long term synaptic depression  postsynaptic density membrane  regulation of postsynaptic cytosolic calcium ion concentration  neurotransmitter receptor activity involved in regulation of postsynaptic cytosolic calcium ion concentration  transmitter-gated ion channel activity involved in regulation of postsynaptic membrane potential  
Ontology : EGO-EBIGolgi membrane  AMPA glutamate receptor activity  excitatory extracellular ligand-gated ion channel activity  extracellular-glutamate-gated ion channel activity  protein binding  endoplasmic reticulum membrane  plasma membrane  ER to Golgi vesicle-mediated transport  signal transduction  chemical synaptic transmission  long-term memory  synaptic vesicle  glutamate receptor activity  cell surface  ER to Golgi transport vesicle membrane  postsynaptic density  cell junction  PDZ domain binding  dendrite  endocytic vesicle membrane  receptor internalization  AMPA glutamate receptor complex  AMPA glutamate receptor complex  dendritic spine membrane  endoplasmic reticulum-Golgi intermediate compartment membrane  ion transmembrane transport  ionotropic glutamate receptor signaling pathway  neuronal cell body  dendritic spine  axonal spine  neuron spine  COPII vesicle coating  recycling endosome  excitatory postsynaptic potential  long term synaptic depression  postsynaptic density membrane  regulation of postsynaptic cytosolic calcium ion concentration  neurotransmitter receptor activity involved in regulation of postsynaptic cytosolic calcium ion concentration  transmitter-gated ion channel activity involved in regulation of postsynaptic membrane potential  
Pathways : KEGG   
NDEx NetworkGRIA1
Atlas of Cancer Signalling NetworkGRIA1
Wikipedia pathwaysGRIA1
Orthology - Evolution
OrthoDB2890
GeneTree (enSembl)ENSG00000155511
Phylogenetic Trees/Animal Genes : TreeFamGRIA1
HOVERGENP42261
HOGENOMP42261
Homologs : HomoloGeneGRIA1
Homology/Alignments : Family Browser (UCSC)GRIA1
Gene fusions - Rearrangements
Fusion : MitelmanSQSTM1/GRIA1 [5q35.3/5q33.2]  [t(5;5)(q33;q35)]  
Fusion: TCGASQSTM1 5q35.3 GRIA1 5q33.2 LUAD
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerGRIA1 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)GRIA1
dbVarGRIA1
ClinVarGRIA1
1000_GenomesGRIA1 
Exome Variant ServerGRIA1
ExAC (Exome Aggregation Consortium)GRIA1 (select the gene name)
Genetic variants : HAPMAP2890
Genomic Variants (DGV)GRIA1 [DGVbeta]
DECIPHERGRIA1 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisGRIA1 
Mutations
ICGC Data PortalGRIA1 
TCGA Data PortalGRIA1 
Broad Tumor PortalGRIA1
OASIS PortalGRIA1 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICGRIA1  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDGRIA1
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch GRIA1
DgiDB (Drug Gene Interaction Database)GRIA1
DoCM (Curated mutations)GRIA1 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)GRIA1 (select a term)
intoGenGRIA1
Cancer3DGRIA1(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM138248   
Orphanet
MedgenGRIA1
Genetic Testing Registry GRIA1
NextProtP42261 [Medical]
TSGene2890
GENETestsGRIA1
Target ValidationGRIA1
Huge Navigator GRIA1 [HugePedia]
snp3D : Map Gene to Disease2890
BioCentury BCIQGRIA1
ClinGenGRIA1
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD2890
Chemical/Pharm GKB GenePA28966
Clinical trialGRIA1
Miscellaneous
canSAR (ICR)GRIA1 (select the gene name)
Probes
Litterature
PubMed115 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineGRIA1
EVEXGRIA1
GoPubMedGRIA1
iHOPGRIA1
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Tue Aug 1 17:02:28 CEST 2017

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