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GRIA2 (glutamate ionotropic receptor AMPA type subunit 2)

Identity

Alias_namesGLUR2
glutamate receptor
Alias_symbol (synonym)GluA2
GLURB
Other aliasGluR-K2
HBGR2
HGNC (Hugo) GRIA2
LocusID (NCBI) 2891
Atlas_Id 52897
Location 4q32.1  [Link to chromosome band 4q32]
Location_base_pair Starts at 158141736 and ends at 158287226 bp from pter ( according to hg19-Feb_2009)
Fusion genes
(updated 2016)
ARPC4-TTLL3 (3p25.3) / GRIA2 (4q32.1)ETV6 (12p13.2) / GRIA2 (4q32.1)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)GRIA2   4572
Cards
Entrez_Gene (NCBI)GRIA2  2891  glutamate ionotropic receptor AMPA type subunit 2
AliasesGLUR2; GLURB; GluA2; GluR-K2; 
HBGR2
GeneCards (Weizmann)GRIA2
Ensembl hg19 (Hinxton)ENSG00000120251 [Gene_View]  chr4:158141736-158287226 [Contig_View]  GRIA2 [Vega]
Ensembl hg38 (Hinxton)ENSG00000120251 [Gene_View]  chr4:158141736-158287226 [Contig_View]  GRIA2 [Vega]
ICGC DataPortalENSG00000120251
TCGA cBioPortalGRIA2
AceView (NCBI)GRIA2
Genatlas (Paris)GRIA2
WikiGenes2891
SOURCE (Princeton)GRIA2
Genetics Home Reference (NIH)GRIA2
Genomic and cartography
GoldenPath hg19 (UCSC)GRIA2  -     chr4:158141736-158287226 +  4q32.1   [Description]    (hg19-Feb_2009)
GoldenPath hg38 (UCSC)GRIA2  -     4q32.1   [Description]    (hg38-Dec_2013)
EnsemblGRIA2 - 4q32.1 [CytoView hg19]  GRIA2 - 4q32.1 [CytoView hg38]
Mapping of homologs : NCBIGRIA2 [Mapview hg19]  GRIA2 [Mapview hg38]
OMIM138247   
Gene and transcription
Genbank (Entrez)AB209567 AK294458 AK308775 AK309067 AL708924
RefSeq transcript (Entrez)NM_000826 NM_001083619 NM_001083620
RefSeq genomic (Entrez)NC_000004 NC_018915 NT_016354 NW_004929320
Consensus coding sequences : CCDS (NCBI)GRIA2
Cluster EST : UnigeneHs.32763 [ NCBI ]
CGAP (NCI)Hs.32763
Alternative Splicing GalleryENSG00000120251
Gene ExpressionGRIA2 [ NCBI-GEO ]   GRIA2 [ EBI - ARRAY_EXPRESS ]   GRIA2 [ SEEK ]   GRIA2 [ MEM ]
Gene Expression Viewer (FireBrowse)GRIA2 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)2891
GTEX Portal (Tissue expression)GRIA2
Protein : pattern, domain, 3D structure
UniProt/SwissProtP42262   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtP42262  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProP42262
Splice isoforms : SwissVarP42262
PhosPhoSitePlusP42262
Domains : Interpro (EBI)ANF_lig-bd_rcpt    Glu/Gly-bd    Iono_rcpt_met    Iontro_rcpt    Peripla_BP_I   
Domain families : Pfam (Sanger)ANF_receptor (PF01094)    Lig_chan (PF00060)    Lig_chan-Glu_bd (PF10613)   
Domain families : Pfam (NCBI)pfam01094    pfam00060    pfam10613   
Domain families : Smart (EMBL)Lig_chan-Glu_bd (SM00918)  PBPe (SM00079)  
Conserved Domain (NCBI)GRIA2
DMDM Disease mutations2891
Blocks (Seattle)GRIA2
PDB (SRS)2WJW    2WJX    2XHD    3R7X    3RN8    3RNN    3UA8   
PDB (PDBSum)2WJW    2WJX    2XHD    3R7X    3RN8    3RNN    3UA8   
PDB (IMB)2WJW    2WJX    2XHD    3R7X    3RN8    3RNN    3UA8   
PDB (RSDB)2WJW    2WJX    2XHD    3R7X    3RN8    3RNN    3UA8   
Structural Biology KnowledgeBase2WJW    2WJX    2XHD    3R7X    3RN8    3RNN    3UA8   
SCOP (Structural Classification of Proteins)2WJW    2WJX    2XHD    3R7X    3RN8    3RNN    3UA8   
CATH (Classification of proteins structures)2WJW    2WJX    2XHD    3R7X    3RN8    3RNN    3UA8   
SuperfamilyP42262
Human Protein AtlasENSG00000120251
Peptide AtlasP42262
HPRD04726
IPIIPI00030882   IPI00219216   IPI00871510   IPI00156955   IPI01013900   IPI00967519   IPI00789563   IPI01012058   IPI00964942   IPI00965707   IPI00965457   IPI00963828   IPI00965203   IPI00966512   
Protein Interaction databases
DIP (DOE-UCLA)P42262
IntAct (EBI)P42262
FunCoupENSG00000120251
BioGRIDGRIA2
STRING (EMBL)GRIA2
ZODIACGRIA2
Ontologies - Pathways
QuickGOP42262
Ontology : AmiGOionotropic glutamate receptor activity  AMPA glutamate receptor activity  excitatory extracellular ligand-gated ion channel activity  extracellular-glutamate-gated ion channel activity  protein binding  endoplasmic reticulum membrane  plasma membrane  integral component of plasma membrane  signal transduction  synaptic transmission  cell junction  endocytic vesicle membrane  AMPA glutamate receptor complex  AMPA glutamate receptor complex  ion transmembrane transport  ion transmembrane transport  ionotropic glutamate receptor signaling pathway  postsynaptic membrane  
Ontology : EGO-EBIionotropic glutamate receptor activity  AMPA glutamate receptor activity  excitatory extracellular ligand-gated ion channel activity  extracellular-glutamate-gated ion channel activity  protein binding  endoplasmic reticulum membrane  plasma membrane  integral component of plasma membrane  signal transduction  synaptic transmission  cell junction  endocytic vesicle membrane  AMPA glutamate receptor complex  AMPA glutamate receptor complex  ion transmembrane transport  ion transmembrane transport  ionotropic glutamate receptor signaling pathway  postsynaptic membrane  
Pathways : BIOCARTAFOSB gene expression and drug abuse [Genes]   
Pathways : KEGGNeuroactive ligand-receptor interaction    Circadian entrainment    Long-term potentiation    Retrograde endocannabinoid signaling    Glutamatergic synapse    Dopaminergic synapse    Long-term depression    Amyotrophic lateral sclerosis (ALS)    Cocaine addiction    Amphetamine addiction    Nicotine addiction   
NDEx NetworkGRIA2
Atlas of Cancer Signalling NetworkGRIA2
Wikipedia pathwaysGRIA2
Orthology - Evolution
OrthoDB2891
GeneTree (enSembl)ENSG00000120251
Phylogenetic Trees/Animal Genes : TreeFamGRIA2
HOVERGENP42262
HOGENOMP42262
Homologs : HomoloGeneGRIA2
Homology/Alignments : Family Browser (UCSC)GRIA2
Gene fusions - Rearrangements
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerGRIA2 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)GRIA2
dbVarGRIA2
ClinVarGRIA2
1000_GenomesGRIA2 
Exome Variant ServerGRIA2
ExAC (Exome Aggregation Consortium)GRIA2 (select the gene name)
Genetic variants : HAPMAP2891
Genomic Variants (DGV)GRIA2 [DGVbeta]
DECIPHER (Syndromes)4:158141736-158287226  ENSG00000120251
CONAN: Copy Number AnalysisGRIA2 
Mutations
ICGC Data PortalGRIA2 
TCGA Data PortalGRIA2 
Broad Tumor PortalGRIA2
OASIS PortalGRIA2 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICGRIA2  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDGRIA2
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch GRIA2
DgiDB (Drug Gene Interaction Database)GRIA2
DoCM (Curated mutations)GRIA2 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)GRIA2 (select a term)
intoGenGRIA2
Cancer3DGRIA2(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM138247   
Orphanet
MedgenGRIA2
Genetic Testing Registry GRIA2
NextProtP42262 [Medical]
TSGene2891
GENETestsGRIA2
Huge Navigator GRIA2 [HugePedia]
snp3D : Map Gene to Disease2891
BioCentury BCIQGRIA2
ClinGenGRIA2
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD2891
Chemical/Pharm GKB GenePA28967
Clinical trialGRIA2
Miscellaneous
canSAR (ICR)GRIA2 (select the gene name)
Probes
Litterature
PubMed104 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineGRIA2
EVEXGRIA2
GoPubMedGRIA2
iHOPGRIA2
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Tue Mar 14 13:08:11 CET 2017

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