GRIA2 (glutamate ionotropic receptor AMPA type subunit 2)

2012-09-01  

Identity

HGNC
LOCATION
4q32.1
LOCUSID
ALIAS
GLUR2,GLURB,GluA2,GluR-K2,HBGR2,NEDLIB,gluR-2,gluR-B
FUSION GENES

Other Information

Locus ID:

NCBI: 2891
MIM: 138247
HGNC: 4572
Ensembl: ENSG00000120251

Variants:

dbSNP: 2891
ClinVar: 2891
TCGA: ENSG00000120251
COSMIC: GRIA2

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000120251ENST00000264426P42262
ENSG00000120251ENST00000296526P42262
ENSG00000120251ENST00000323661F8W7L6
ENSG00000120251ENST00000393815P42262
ENSG00000120251ENST00000503437D6REK8
ENSG00000120251ENST00000505888D6R9Z0
ENSG00000120251ENST00000506284D6RFM6
ENSG00000120251ENST00000507898P42262
ENSG00000120251ENST00000509417D6RDX5
ENSG00000120251ENST00000510854H0Y972
ENSG00000120251ENST00000512774D6RBV7
ENSG00000120251ENST00000645636P42262

Expression (GTEx)

0
10
20
30
40
50
60
70
80

Pathways

PathwaySourceExternal ID
Neuroactive ligand-receptor interactionKEGGko04080
Long-term potentiationKEGGko04720
Long-term depressionKEGGko04730
Amyotrophic lateral sclerosis (ALS)KEGGko05014
Neuroactive ligand-receptor interactionKEGGhsa04080
Long-term potentiationKEGGhsa04720
Long-term depressionKEGGhsa04730
Amyotrophic lateral sclerosis (ALS)KEGGhsa05014
Glutamatergic synapseKEGGko04724
Glutamatergic synapseKEGGhsa04724
Dopaminergic synapseKEGGko04728
Dopaminergic synapseKEGGhsa04728
Retrograde endocannabinoid signalingKEGGhsa04723
Retrograde endocannabinoid signalingKEGGko04723
Cocaine addictionKEGGhsa05030
Cocaine addictionKEGGko05030
Amphetamine addictionKEGGhsa05031
Amphetamine addictionKEGGko05031
Nicotine addictionKEGGhsa05033
Nicotine addictionKEGGko05033
Circadian entrainmentKEGGhsa04713
Circadian entrainmentKEGGko04713
cAMP signaling pathwayKEGGhsa04024
cAMP signaling pathwayKEGGko04024
Neuronal SystemREACTOMER-HSA-112316
Transmission across Chemical SynapsesREACTOMER-HSA-112315
Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic CellREACTOMER-HSA-112314
Glutamate Binding, Activation of AMPA Receptors and Synaptic PlasticityREACTOMER-HSA-399721
Trafficking of AMPA receptorsREACTOMER-HSA-399719
Trafficking of GluR2-containing AMPA receptorsREACTOMER-HSA-416993
Activation of AMPA receptorsREACTOMER-HSA-399710
Activation of NMDA receptor upon glutamate binding and postsynaptic eventsREACTOMER-HSA-442755
Unblocking of NMDA receptor, glutamate binding and activationREACTOMER-HSA-438066

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
149857492004Glutamate receptors: RNA editing and death of motor neurons.151
194481892009A genomewide association study of response to lithium for prevention of recurrence in bipolar disorder.47
199337742010Glutamatergic (N-methyl-D-aspartate receptor) hypofrontality in schizophrenia: too little juice or a miswired brain?47
191561682009Pharmacogenetics of antipsychotic response in the CATIE trial: a candidate gene analysis.46
196511382009Crystal structure of the GluR2 amino-terminal domain provides insights into the architecture and assembly of ionotropic glutamate receptors.44
184036312008Calcium-permeable AMPA receptors containing Q/R-unedited GluR2 direct human neural progenitor cell differentiation to neurons.37
218564332011AMPA receptor regulation during synaptic plasticity in hippocampus and neocortex.35
190860532009Identification of new putative susceptibility genes for several psychiatric disorders by association analysis of regulatory and non-synonymous SNPs of 306 genes involved in neurotransmission and neurodevelopment.34
203472652010MicroRNAs and target site screening reveals a pre-microRNA-30e variant associated with schizophrenia.34
203989082010Comprehensive copy number variant (CNV) analysis of neuronal pathways genes in psychiatric disorders identifies rare variants within patients.32

Citation

Dessen P

GRIA2 (glutamate ionotropic receptor AMPA type subunit 2)

Atlas Genet Cytogenet Oncol Haematol. 2012-09-01

Online version: http://atlasgeneticsoncology.org/gene/52897/gria2