GRIA2 (glutamate ionotropic receptor AMPA type subunit 2)

2012-09-01  

Identity

HGNC
GRIA2
LOCATION
4q32.1
LOCUSID
2891
ALIAS
GLUR2,GLURB,GluA2,GluR-K2,HBGR2,NEDLIB,gluR-2,gluR-B
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 2891
MIM: 138247
HGNC: 4572
Ensembl: ENSG00000120251

Variants:

dbSNP: 2891
ClinVar: 2891
TCGA: ENSG00000120251
COSMIC: GRIA2

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000120251ENST00000264426P42262
ENSG00000120251ENST00000296526P42262
ENSG00000120251ENST00000323661F8W7L6
ENSG00000120251ENST00000393815P42262
ENSG00000120251ENST00000503437D6REK8
ENSG00000120251ENST00000505888D6R9Z0
ENSG00000120251ENST00000506284D6RFM6
ENSG00000120251ENST00000507898P42262
ENSG00000120251ENST00000509417D6RDX5
ENSG00000120251ENST00000510854H0Y972
ENSG00000120251ENST00000512774D6RBV7
ENSG00000120251ENST00000645636P42262

Expression (GTEx)

0
10
20
30
40
50
60
70
80
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Neuroactive ligand-receptor interactionKEGGko04080
Long-term potentiationKEGGko04720
Long-term depressionKEGGko04730
Amyotrophic lateral sclerosis (ALS)KEGGko05014
Neuroactive ligand-receptor interactionKEGGhsa04080
Long-term potentiationKEGGhsa04720
Long-term depressionKEGGhsa04730
Amyotrophic lateral sclerosis (ALS)KEGGhsa05014
Glutamatergic synapseKEGGko04724
Glutamatergic synapseKEGGhsa04724
Dopaminergic synapseKEGGko04728
Dopaminergic synapseKEGGhsa04728
Retrograde endocannabinoid signalingKEGGhsa04723
Retrograde endocannabinoid signalingKEGGko04723
Cocaine addictionKEGGhsa05030
Cocaine addictionKEGGko05030
Amphetamine addictionKEGGhsa05031
Amphetamine addictionKEGGko05031
Nicotine addictionKEGGhsa05033
Nicotine addictionKEGGko05033
Circadian entrainmentKEGGhsa04713
Circadian entrainmentKEGGko04713
cAMP signaling pathwayKEGGhsa04024
cAMP signaling pathwayKEGGko04024
Neuronal SystemREACTOMER-HSA-112316
Transmission across Chemical SynapsesREACTOMER-HSA-112315
Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic CellREACTOMER-HSA-112314
Glutamate Binding, Activation of AMPA Receptors and Synaptic PlasticityREACTOMER-HSA-399721
Trafficking of AMPA receptorsREACTOMER-HSA-399719
Trafficking of GluR2-containing AMPA receptorsREACTOMER-HSA-416993
Activation of AMPA receptorsREACTOMER-HSA-399710
Activation of NMDA receptor upon glutamate binding and postsynaptic eventsREACTOMER-HSA-442755
Unblocking of NMDA receptor, glutamate binding and activationREACTOMER-HSA-438066

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
325811552020Internalization of AMPA-type Glutamate Receptor in the MIN6 Pancreatic β-cell Line.2
325811552020Internalization of AMPA-type Glutamate Receptor in the MIN6 Pancreatic β-cell Line.2
310534082019Nanoscale Mobility of the Apo State and TARP Stoichiometry Dictate the Gating Behavior of Alternatively Spliced AMPA Receptors.16
313006572019AMPA receptor GluA2 subunit defects are a cause of neurodevelopmental disorders.100
314543622019Inhibition and assessment of the biophysical gating properties of GluA2 and GluA2/A3 AMPA receptors using curcumin derivatives.7
310534082019Nanoscale Mobility of the Apo State and TARP Stoichiometry Dictate the Gating Behavior of Alternatively Spliced AMPA Receptors.16
313006572019AMPA receptor GluA2 subunit defects are a cause of neurodevelopmental disorders.100
314543622019Inhibition and assessment of the biophysical gating properties of GluA2 and GluA2/A3 AMPA receptors using curcumin derivatives.7
293395352018Functional changes of AMPA responses in human induced pluripotent stem cell-derived neural progenitors in fragile X syndrome.33
296180042018The antidepressant tianeptine reverts synaptic AMPA receptor defects caused by deficiency of CDKL5.16
293395352018Functional changes of AMPA responses in human induced pluripotent stem cell-derived neural progenitors in fragile X syndrome.33
296180042018The antidepressant tianeptine reverts synaptic AMPA receptor defects caused by deficiency of CDKL5.16
281953082017Ca(2+) -permeable AMPA receptors associated with epileptogenesis of hypothalamic hamartoma.7
286087432017Obsessive-compulsive disorder, which genes? Which functions? Which pathways? An integrated holistic view regarding OCD and its complex genetic etiology.7
281953082017Ca(2+) -permeable AMPA receptors associated with epileptogenesis of hypothalamic hamartoma.7

Citation

Dessen P

GRIA2 (glutamate ionotropic receptor AMPA type subunit 2)

Atlas Genet Cytogenet Oncol Haematol. 2012-09-01

Online version: http://atlasgeneticsoncology.org/gene/52897/gria2