Atlas of Genetics and Cytogenetics in Oncology and Haematology

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GRIA4 (glutamate ionotropic receptor AMPA type subunit 4)

Identity

Alias_namesGLUR4
glutamate receptor, ionotrophic, AMPA 4
Alias_symbol (synonym)GluA4
GLURD
Other aliasGLUR4C
HGNC (Hugo) GRIA4
LocusID (NCBI) 2893
Atlas_Id 64035
Location 11q22.3  [Link to chromosome band 11q22]
Location_base_pair Starts at 105610073 and ends at 105982092 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)		Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
GRIA4 (11q22.3) / NAALAD2 (11q14.3)TMEM126B (11q14.1) / GRIA4 (11q22.3)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 

External links

Nomenclature
HGNC (Hugo)GRIA4   4574
Cards
Entrez_Gene (NCBI)GRIA4  2893  glutamate ionotropic receptor AMPA type subunit 4
AliasesGLUR4; GLUR4C; GLURD; GluA4
GeneCards (Weizmann)GRIA4
Ensembl hg19 (Hinxton)ENSG00000152578 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000152578 [Gene_View]  ENSG00000152578 [Sequence]  chr11:105610073-105982092 [Contig_View]  GRIA4 [Vega]
ICGC DataPortalENSG00000152578
TCGA cBioPortalGRIA4
AceView (NCBI)GRIA4
Genatlas (Paris)GRIA4
WikiGenes2893
SOURCE (Princeton)GRIA4
Genetics Home Reference (NIH)GRIA4
Genomic and cartography
GoldenPath hg38 (UCSC)GRIA4  -     chr11:105610073-105982092 +  11q22.3   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)GRIA4  -     11q22.3   [Description]    (hg19-Feb_2009)
GoldenPathGRIA4 - 11q22.3 [CytoView hg19]  GRIA4 - 11q22.3 [CytoView hg38]
ImmunoBaseENSG00000152578
Mapping of homologs : NCBIGRIA4 [Mapview hg19]  GRIA4 [Mapview hg38]
OMIM138246   
Gene and transcription
Genbank (Entrez)AB115416 AB209092 AK311193 BC015199 BC035610
RefSeq transcript (Entrez)NM_000829 NM_001077243 NM_001077244 NM_001112812
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)GRIA4
Cluster EST : UnigeneHs.503743 [ NCBI ]
CGAP (NCI)Hs.503743
Alternative Splicing GalleryENSG00000152578
Gene ExpressionGRIA4 [ NCBI-GEO ]   GRIA4 [ EBI - ARRAY_EXPRESS ]   GRIA4 [ SEEK ]   GRIA4 [ MEM ]
Gene Expression Viewer (FireBrowse)GRIA4 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevestigatorExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)2893
GTEX Portal (Tissue expression)GRIA4
Human Protein AtlasENSG00000152578-GRIA4 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtP48058   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtP48058  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProP48058
Splice isoforms : SwissVarP48058
PhosPhoSitePlusP48058
Domains : Interpro (EBI)ANF_lig-bd_rcpt    Glu/Gly-bd    Iono_rcpt_met    Iontro_rcpt    Peripla_BP_I   
Domain families : Pfam (Sanger)ANF_receptor (PF01094)    Lig_chan (PF00060)    Lig_chan-Glu_bd (PF10613)   
Domain families : Pfam (NCBI)pfam01094    pfam00060    pfam10613   
Domain families : Smart (EMBL)Lig_chan-Glu_bd (SM00918)  PBPe (SM00079)  
Conserved Domain (NCBI)GRIA4
DMDM Disease mutations2893
Blocks (Seattle)GRIA4
SuperfamilyP48058
Human Protein Atlas [tissue]ENSG00000152578-GRIA4 [tissue]
Peptide AtlasP48058
HPRD00694
IPIIPI00007632   IPI00973100   IPI00980961   IPI00791228   IPI00979622   IPI00982859   IPI00718977   
Protein Interaction databases
DIP (DOE-UCLA)P48058
IntAct (EBI)P48058
FunCoupENSG00000152578
BioGRIDGRIA4
STRING (EMBL)GRIA4
ZODIACGRIA4
Ontologies - Pathways
QuickGOP48058
Ontology : AmiGOionotropic glutamate receptor activity  AMPA glutamate receptor activity  excitatory extracellular ligand-gated ion channel activity  extracellular-glutamate-gated ion channel activity  plasma membrane  transport  glutamate receptor signaling pathway  cell junction  dendrite  endocytic vesicle membrane  AMPA glutamate receptor complex  AMPA glutamate receptor complex  ion transmembrane transport  ionotropic glutamate receptor signaling pathway  postsynaptic membrane  excitatory postsynaptic potential  extracellular vesicle  
Ontology : EGO-EBIionotropic glutamate receptor activity  AMPA glutamate receptor activity  excitatory extracellular ligand-gated ion channel activity  extracellular-glutamate-gated ion channel activity  plasma membrane  transport  glutamate receptor signaling pathway  cell junction  dendrite  endocytic vesicle membrane  AMPA glutamate receptor complex  AMPA glutamate receptor complex  ion transmembrane transport  ionotropic glutamate receptor signaling pathway  postsynaptic membrane  excitatory postsynaptic potential  extracellular vesicle  
Pathways : KEGGNeuroactive ligand-receptor interaction   
NDEx NetworkGRIA4
Atlas of Cancer Signalling NetworkGRIA4
Wikipedia pathwaysGRIA4
Orthology - Evolution
OrthoDB2893
GeneTree (enSembl)ENSG00000152578
Phylogenetic Trees/Animal Genes : TreeFamGRIA4
HOGENOMP48058
Homologs : HomoloGeneGRIA4
Homology/Alignments : Family Browser (UCSC)GRIA4
Gene fusions - Rearrangements
Fusion : QuiverGRIA4
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerGRIA4 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)GRIA4
dbVarGRIA4
ClinVarGRIA4
1000_GenomesGRIA4 
Exome Variant ServerGRIA4
ExAC (Exome Aggregation Consortium)ENSG00000152578
GNOMAD BrowserENSG00000152578
Varsome BrowserGRIA4
Genetic variants : HAPMAP2893
Genomic Variants (DGV)GRIA4 [DGVbeta]
DECIPHERGRIA4 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisGRIA4 
Mutations
ICGC Data PortalGRIA4 
TCGA Data PortalGRIA4 
Broad Tumor PortalGRIA4
OASIS PortalGRIA4 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICGRIA4  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDGRIA4
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch GRIA4
DgiDB (Drug Gene Interaction Database)GRIA4
DoCM (Curated mutations)GRIA4 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)GRIA4 (select a term)
intoGenGRIA4
Cancer3DGRIA4(select the gene name)
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM138246   
Orphanet
DisGeNETGRIA4
MedgenGRIA4
Genetic Testing Registry GRIA4
NextProtP48058 [Medical]
TSGene2893
GENETestsGRIA4
Target ValidationGRIA4
Huge Navigator GRIA4 [HugePedia]
snp3D : Map Gene to Disease2893
BioCentury BCIQGRIA4
ClinGenGRIA4
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD2893
Chemical/Pharm GKB GenePA28969
Clinical trialGRIA4
Miscellaneous
canSAR (ICR)GRIA4 (select the gene name)
DataMed IndexGRIA4
Probes
Litterature
PubMed54 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineGRIA4
EVEXGRIA4
GoPubMedGRIA4
iHOPGRIA4
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Fri Jun 7 17:19:25 CEST 2019
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