Atlas of Genetics and Cytogenetics in Oncology and Haematology

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GRID1 (glutamate ionotropic receptor delta type subunit 1)

Identity

Alias_namesglutamate receptor
Alias_symbol (synonym)GluD1
KIAA1220
Other alias
HGNC (Hugo) GRID1
LocusID (NCBI) 2894
Atlas_Id 40752
Location 10q23.1  [Link to chromosome band 10q23]
Location_base_pair Starts at 85599555 and ends at 86366493 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)		Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
COL1A1 (17q21.33) / GRID1 (10q23.1)CYTH3 (7p22.1) / GRID1 (10q23.1)DPM1 (20q13.13) / GRID1 (10q23.1)
GRID1 (10q23.1) / HECTD2 (10q23.32)GRID1 (10q23.1) / NFIC (19p13.3)GRID1 (10q23.1) / PGPEP1L (15q26.3)
GRID1 (10q23.1) / WAPL (10q23.2)SGMS1 (10q11.23) / GRID1 (10q23.1)TRAPPC10 (21q22.3) / GRID1 (10q23.1)
CYTH3 7p22.1 / GRID1 10q23.1DPM1 20q13.13 / GRID1 10q23.1GRID1 10q23.1 / HECTD2 10q23.32
GRID1 10q23.1 / PGPEP1L 15q26.3SGMS1 10q11.23 / GRID1 10q23.1TRAPPC10 21q22.3 / GRID1 10q23.1

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 

Other Leukemias implicated (Data extracted from papers in the Atlas) [ 2 ]
  t(10;20)(q23;q13) DPM1/GRID1
t(10;20)(q23;q13) GRID1/DPM1

Other Solid tumors implicated (Data extracted from papers in the Atlas) [ 5 ]
  t(7;10)(p22;q23) CYTH3/GRID1
t(10;10)(q11;q23) SGMS1/GRID1
GRID1/HECTD2 (10q23)
t(10;15)(q23;q26) GRID1/PGPEP1L
t(10;21)(q23;q22) TRAPPC10/GRID1

External links

Nomenclature
HGNC (Hugo)GRID1   4575
Cards
Entrez_Gene (NCBI)GRID1  2894  glutamate ionotropic receptor delta type subunit 1
AliasesGluD1
GeneCards (Weizmann)GRID1
Ensembl hg19 (Hinxton)ENSG00000182771 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000182771 [Gene_View]  ENSG00000182771 [Sequence]  chr10:85599555-86366493 [Contig_View]  GRID1 [Vega]
ICGC DataPortalENSG00000182771
TCGA cBioPortalGRID1
AceView (NCBI)GRID1
Genatlas (Paris)GRID1
WikiGenes2894
SOURCE (Princeton)GRID1
Genetics Home Reference (NIH)GRID1
Genomic and cartography
GoldenPath hg38 (UCSC)GRID1  -     chr10:85599555-86366493 -  10q23.1   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)GRID1  -     10q23.1   [Description]    (hg19-Feb_2009)
GoldenPathGRID1 - 10q23.1 [CytoView hg19]  GRID1 - 10q23.1 [CytoView hg38]
ImmunoBaseENSG00000182771
Mapping of homologs : NCBIGRID1 [Mapview hg19]  GRID1 [Mapview hg38]
OMIM610659   
Gene and transcription
Genbank (Entrez)AB033046 AK127168 AK293104 AK302192 BC039263
RefSeq transcript (Entrez)NM_017551
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)GRID1
Cluster EST : UnigeneHs.530653 [ NCBI ]
CGAP (NCI)Hs.530653
Alternative Splicing GalleryENSG00000182771
Gene ExpressionGRID1 [ NCBI-GEO ]   GRID1 [ EBI - ARRAY_EXPRESS ]   GRID1 [ SEEK ]   GRID1 [ MEM ]
Gene Expression Viewer (FireBrowse)GRID1 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevestigatorExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)2894
GTEX Portal (Tissue expression)GRID1
Human Protein AtlasENSG00000182771-GRID1 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ9ULK0   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ9ULK0  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ9ULK0
Splice isoforms : SwissVarQ9ULK0
PhosPhoSitePlusQ9ULK0
Domains : Interpro (EBI)ANF_lig-bd_rcpt    Glu/Gly-bd    Iono_rcpt_met    Iontro_rcpt    Peripla_BP_I   
Domain families : Pfam (Sanger)ANF_receptor (PF01094)    Lig_chan (PF00060)    Lig_chan-Glu_bd (PF10613)   
Domain families : Pfam (NCBI)pfam01094    pfam00060    pfam10613   
Domain families : Smart (EMBL)Lig_chan-Glu_bd (SM00918)  PBPe (SM00079)  
Conserved Domain (NCBI)GRID1
DMDM Disease mutations2894
Blocks (Seattle)GRID1
SuperfamilyQ9ULK0
Human Protein Atlas [tissue]ENSG00000182771-GRID1 [tissue]
Peptide AtlasQ9ULK0
HPRD17078
IPIIPI00374337   IPI01012961   IPI00979547   
Protein Interaction databases
DIP (DOE-UCLA)Q9ULK0
IntAct (EBI)Q9ULK0
FunCoupENSG00000182771
BioGRIDGRID1
STRING (EMBL)GRID1
ZODIACGRID1
Ontologies - Pathways
QuickGOQ9ULK0
Ontology : AmiGOionotropic glutamate receptor activity  plasma membrane  glutamate receptor activity  cell junction  ion transmembrane transport  social behavior  ionotropic glutamate receptor signaling pathway  synaptic transmission, glutamatergic  postsynaptic membrane  modulation of chemical synaptic transmission  extracellular exosome  glutamatergic synapse  integral component of postsynaptic density membrane  transmitter-gated ion channel activity involved in regulation of postsynaptic membrane potential  
Ontology : EGO-EBIionotropic glutamate receptor activity  plasma membrane  glutamate receptor activity  cell junction  ion transmembrane transport  social behavior  ionotropic glutamate receptor signaling pathway  synaptic transmission, glutamatergic  postsynaptic membrane  modulation of chemical synaptic transmission  extracellular exosome  glutamatergic synapse  integral component of postsynaptic density membrane  transmitter-gated ion channel activity involved in regulation of postsynaptic membrane potential  
Pathways : KEGGNeuroactive ligand-receptor interaction   
NDEx NetworkGRID1
Atlas of Cancer Signalling NetworkGRID1
Wikipedia pathwaysGRID1
Orthology - Evolution
OrthoDB2894
GeneTree (enSembl)ENSG00000182771
Phylogenetic Trees/Animal Genes : TreeFamGRID1
HOGENOMQ9ULK0
Homologs : HomoloGeneGRID1
Homology/Alignments : Family Browser (UCSC)GRID1
Gene fusions - Rearrangements
Fusion : MitelmanCYTH3/GRID1 [7p22.1/10q23.1]  [t(7;10)(p22;q23)]  
Fusion : MitelmanDPM1/GRID1 [20q13.13/10q23.1]  [t(10;20)(q23;q13)]  
Fusion : MitelmanGRID1/HECTD2 [10q23.1/10q23.32]  [t(10;10)(q23;q23)]  
Fusion : MitelmanGRID1/PGPEP1L [10q23.1/15q26.3]  [t(10;15)(q23;q26)]  
Fusion : MitelmanSGMS1/GRID1 [10q11.23/10q23.1]  [t(10;10)(q11;q23)]  
Fusion : MitelmanTRAPPC10/GRID1 [21q22.3/10q23.1]  [t(10;21)(q23;q22)]  
Fusion PortalCYTH3 7p22.1 GRID1 10q23.1 SKCM
Fusion PortalDPM1 20q13.13 GRID1 10q23.1 LAML
Fusion PortalGRID1 10q23.1 HECTD2 10q23.32 SKCM
Fusion PortalGRID1 10q23.1 PGPEP1L 15q26.3 BRCA
Fusion PortalSGMS1 10q11.23 GRID1 10q23.1 HNSC
Fusion PortalTRAPPC10 21q22.3 GRID1 10q23.1 OV
Fusion : QuiverGRID1
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerGRID1 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)GRID1
dbVarGRID1
ClinVarGRID1
1000_GenomesGRID1 
Exome Variant ServerGRID1
ExAC (Exome Aggregation Consortium)ENSG00000182771
GNOMAD BrowserENSG00000182771
Varsome BrowserGRID1
Genetic variants : HAPMAP2894
Genomic Variants (DGV)GRID1 [DGVbeta]
DECIPHERGRID1 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisGRID1 
Mutations
ICGC Data PortalGRID1 
TCGA Data PortalGRID1 
Broad Tumor PortalGRID1
OASIS PortalGRID1 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICGRID1  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDGRID1
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch GRID1
DgiDB (Drug Gene Interaction Database)GRID1
DoCM (Curated mutations)GRID1 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)GRID1 (select a term)
intoGenGRID1
Cancer3DGRID1(select the gene name)
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM610659   
Orphanet
DisGeNETGRID1
MedgenGRID1
Genetic Testing Registry GRID1
NextProtQ9ULK0 [Medical]
TSGene2894
GENETestsGRID1
Target ValidationGRID1
Huge Navigator GRID1 [HugePedia]
snp3D : Map Gene to Disease2894
BioCentury BCIQGRID1
ClinGenGRID1 (curated)
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD2894
Chemical/Pharm GKB GenePA28970
Clinical trialGRID1
Miscellaneous
canSAR (ICR)GRID1 (select the gene name)
DataMed IndexGRID1
Probes
Litterature
PubMed26 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineGRID1
EVEXGRID1
GoPubMedGRID1
iHOPGRID1
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Mon Jul 8 11:22:14 CEST 2019
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