GRID2 (glutamate ionotropic receptor delta type subunit 2)

2003-05-01  

Identity

HGNC
LOCATION
4q22.1
LOCUSID
ALIAS
GluD2,SCAR18
FUSION GENES

Other Information

Locus ID:

NCBI: 2895
MIM: 602368
HGNC: 4576
Ensembl: ENSG00000152208

Variants:

dbSNP: 2895
ClinVar: 2895
TCGA: ENSG00000152208
COSMIC: GRID2

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000152208ENST00000282020O43424
ENSG00000152208ENST00000502699D6R9W8
ENSG00000152208ENST00000510992O43424
ENSG00000152208ENST00000512631D6R976
ENSG00000152208ENST00000513976H0YA12
ENSG00000152208ENST00000611049A0A087X043
ENSG00000152208ENST00000637838A0A1B0GW49

Expression (GTEx)

0
5
10
15

Pathways

PathwaySourceExternal ID
Neuroactive ligand-receptor interactionKEGGko04080
Long-term depressionKEGGko04730
Neuroactive ligand-receptor interactionKEGGhsa04080
Long-term depressionKEGGhsa04730

Protein levels (Protein atlas)

Not detected
Low
Medium
High

PharmGKB

Entity IDNameTypeEvidenceAssociationPKPDPMIDs
PA451257risperidoneChemicalClinicalAnnotationassociatedPD26905411

References

Pubmed IDYearTitleCitations
203796142010Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.62
235121052013Confirming genes influencing risk to cleft lip with/without cleft palate in a case-parent trio study.39
213680482011Glutamate receptor δ2 is essential for input pathway-dependent regulation of synaptic AMPAR contents in cerebellar Purkinje cells.29
240787372013Deletions in GRID2 lead to a recessive syndrome of cerebellar ataxia and tonic upgaze in humans.27
243576602014Type 1 metabotropic glutamate receptors (mGlu1) trigger the gating of GluD2 delta glutamate receptors.27
182562672008Differential regulation of synaptic plasticity and cerebellar motor learning by the C-terminal PDZ-binding motif of GluRdelta2.26
204875062010A whole genome association study of mother-to-child transmission of HIV in Malawi.26
258410242015GRID2 mutations span from congenital to mild adult-onset cerebellar ataxia.22
251221452015Early-onset autosomal recessive cerebellar ataxia associated with retinal dystrophy: new human hotfoot phenotype caused by homozygous GRID2 deletion.16
269054112016Antipsychotic pharmacogenomics in first episode psychosis: a role for glutamate genes.15

Citation

Dessen P

GRID2 (glutamate ionotropic receptor delta type subunit 2)

Atlas Genet Cytogenet Oncol Haematol. 2003-05-01

Online version: http://atlasgeneticsoncology.org/gene/40753/grid2