Atlas of Genetics and Cytogenetics in Oncology and Haematology


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GRIK1 (glutamate receptor, ionotropic, kainate 1)

Identity

Alias_namesGLUR5
glutamate receptor, ionotropic, kainate 1
Alias_symbol (synonym)GluK1
Other aliasEAA3
EEA3
GLR5
HGNC (Hugo) GRIK1
LocusID (NCBI) 2897
Atlas_Id 64039
Location 21q21.3  [Link to chromosome band 21q21]
Location_base_pair Starts at 30925866 and ends at 31312282 bp from pter ( according to hg19-Feb_2009)
Fusion genes
(updated 2016)
ATP6V1E2 (2p21) / GRIK1 (21q21.3)CHTOP (1q21.3) / GRIK1 (21q21.3)HLCS (21q22.13) / GRIK1 (21q21.3)
NCAM2 (21q21.1) / GRIK1 (21q21.3)TRAPPC10 (21q22.3) / GRIK1 (21q21.3)ATP6V1E2 GRIK1
HLCS GRIK1TRAPPC10 GRIK1

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)GRIK1   4579
Cards
Entrez_Gene (NCBI)GRIK1  2897  glutamate receptor, ionotropic, kainate 1
AliasesEAA3; EEA3; GLR5; GLUR5; 
GluK1
GeneCards (Weizmann)GRIK1
Ensembl hg19 (Hinxton)ENSG00000171189 [Gene_View]  chr21:30925866-31312282 [Contig_View]  GRIK1 [Vega]
Ensembl hg38 (Hinxton)ENSG00000171189 [Gene_View]  chr21:30925866-31312282 [Contig_View]  GRIK1 [Vega]
ICGC DataPortalENSG00000171189
TCGA cBioPortalGRIK1
AceView (NCBI)GRIK1
Genatlas (Paris)GRIK1
WikiGenes2897
SOURCE (Princeton)GRIK1
Genetics Home Reference (NIH)GRIK1
Genomic and cartography
GoldenPath hg19 (UCSC)GRIK1  -     chr21:30925866-31312282 -  21q21.3   [Description]    (hg19-Feb_2009)
GoldenPath hg38 (UCSC)GRIK1  -     21q21.3   [Description]    (hg38-Dec_2013)
EnsemblGRIK1 - 21q21.3 [CytoView hg19]  GRIK1 - 21q21.3 [CytoView hg38]
Mapping of homologs : NCBIGRIK1 [Mapview hg19]  GRIK1 [Mapview hg38]
OMIM138245   
Gene and transcription
Genbank (Entrez)AA404271 AJ249208 AK294353 AK296404 BC028238
RefSeq transcript (Entrez)NM_000830 NM_175611
RefSeq genomic (Entrez)NC_000021 NC_018932 NT_011512 NW_004929426
Consensus coding sequences : CCDS (NCBI)GRIK1
Cluster EST : UnigeneHs.670516 [ NCBI ]
CGAP (NCI)Hs.670516
Alternative Splicing GalleryENSG00000171189
Gene ExpressionGRIK1 [ NCBI-GEO ]   GRIK1 [ EBI - ARRAY_EXPRESS ]   GRIK1 [ SEEK ]   GRIK1 [ MEM ]
Gene Expression Viewer (FireBrowse)GRIK1 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)2897
GTEX Portal (Tissue expression)GRIK1
Protein : pattern, domain, 3D structure
UniProt/SwissProtP39086   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtP39086  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProP39086
Splice isoforms : SwissVarP39086
PhosPhoSitePlusP39086
Domains : Interpro (EBI)ANF_lig-bd_rcpt    Glu/Gly-bd    Iono_rcpt_met    Iontro_rcpt    Peripla_BP_I   
Domain families : Pfam (Sanger)ANF_receptor (PF01094)    Lig_chan (PF00060)    Lig_chan-Glu_bd (PF10613)   
Domain families : Pfam (NCBI)pfam01094    pfam00060    pfam10613   
Domain families : Smart (EMBL)Lig_chan-Glu_bd (SM00918)  PBPe (SM00079)  
Conserved Domain (NCBI)GRIK1
DMDM Disease mutations2897
Blocks (Seattle)GRIK1
PDB (SRS)2ZNS    2ZNT    2ZNU    3FUZ    3FV1    3FV2    3FVG    3FVK    3FVN    3FVO    4MF3   
PDB (PDBSum)2ZNS    2ZNT    2ZNU    3FUZ    3FV1    3FV2    3FVG    3FVK    3FVN    3FVO    4MF3   
PDB (IMB)2ZNS    2ZNT    2ZNU    3FUZ    3FV1    3FV2    3FVG    3FVK    3FVN    3FVO    4MF3   
PDB (RSDB)2ZNS    2ZNT    2ZNU    3FUZ    3FV1    3FV2    3FVG    3FVK    3FVN    3FVO    4MF3   
Structural Biology KnowledgeBase2ZNS    2ZNT    2ZNU    3FUZ    3FV1    3FV2    3FVG    3FVK    3FVN    3FVO    4MF3   
SCOP (Structural Classification of Proteins)2ZNS    2ZNT    2ZNU    3FUZ    3FV1    3FV2    3FVG    3FVK    3FVN    3FVO    4MF3   
CATH (Classification of proteins structures)2ZNS    2ZNT    2ZNU    3FUZ    3FV1    3FV2    3FVG    3FVK    3FVN    3FVO    4MF3   
SuperfamilyP39086
Human Protein AtlasENSG00000171189
Peptide AtlasP39086
HPRD00693
IPIIPI00937051   IPI00783047   IPI01013593   IPI01010383   IPI00790891   IPI00790860   IPI00791455   IPI00792018   IPI00792601   
Protein Interaction databases
DIP (DOE-UCLA)P39086
IntAct (EBI)P39086
FunCoupENSG00000171189
BioGRIDGRIK1
STRING (EMBL)GRIK1
ZODIACGRIK1
Ontologies - Pathways
QuickGOP39086
Ontology : AmiGOextracellular-glutamate-gated ion channel activity  plasma membrane  plasma membrane  integral component of plasma membrane  transport  glutamate receptor signaling pathway  synaptic transmission  nervous system development  central nervous system development  positive regulation of gamma-aminobutyric acid secretion  kainate selective glutamate receptor activity  cell junction  dendrite  adult behavior  positive regulation of synaptic transmission, GABAergic  kainate selective glutamate receptor complex  ion transmembrane transport  ionotropic glutamate receptor signaling pathway  ionotropic glutamate receptor signaling pathway  ionotropic glutamate receptor signaling pathway  synaptic transmission, glutamatergic  presynaptic membrane  postsynaptic membrane  behavioral response to pain  regulation of synaptic transmission, glutamatergic  negative regulation of synaptic transmission, glutamatergic  regulation of excitatory postsynaptic membrane potential  regulation of inhibitory postsynaptic membrane potential  neuronal postsynaptic density  
Ontology : EGO-EBIextracellular-glutamate-gated ion channel activity  plasma membrane  plasma membrane  integral component of plasma membrane  transport  glutamate receptor signaling pathway  synaptic transmission  nervous system development  central nervous system development  positive regulation of gamma-aminobutyric acid secretion  kainate selective glutamate receptor activity  cell junction  dendrite  adult behavior  positive regulation of synaptic transmission, GABAergic  kainate selective glutamate receptor complex  ion transmembrane transport  ionotropic glutamate receptor signaling pathway  ionotropic glutamate receptor signaling pathway  ionotropic glutamate receptor signaling pathway  synaptic transmission, glutamatergic  presynaptic membrane  postsynaptic membrane  behavioral response to pain  regulation of synaptic transmission, glutamatergic  negative regulation of synaptic transmission, glutamatergic  regulation of excitatory postsynaptic membrane potential  regulation of inhibitory postsynaptic membrane potential  neuronal postsynaptic density  
Pathways : KEGGNeuroactive ligand-receptor interaction    Glutamatergic synapse   
NDEx NetworkGRIK1
Atlas of Cancer Signalling NetworkGRIK1
Wikipedia pathwaysGRIK1
Orthology - Evolution
OrthoDB2897
GeneTree (enSembl)ENSG00000171189
Phylogenetic Trees/Animal Genes : TreeFamGRIK1
HOVERGENP39086
HOGENOMP39086
Homologs : HomoloGeneGRIK1
Homology/Alignments : Family Browser (UCSC)GRIK1
Gene fusions - Rearrangements
Fusion: TCGAATP6V1E2 GRIK1
Fusion: TCGAHLCS GRIK1
Fusion: TCGATRAPPC10 GRIK1
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerGRIK1 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)GRIK1
dbVarGRIK1
ClinVarGRIK1
1000_GenomesGRIK1 
Exome Variant ServerGRIK1
ExAC (Exome Aggregation Consortium)GRIK1 (select the gene name)
Genetic variants : HAPMAP2897
Genomic Variants (DGV)GRIK1 [DGVbeta]
DECIPHER (Syndromes)21:30925866-31312282  ENSG00000171189
CONAN: Copy Number AnalysisGRIK1 
Mutations
ICGC Data PortalGRIK1 
TCGA Data PortalGRIK1 
Broad Tumor PortalGRIK1
OASIS PortalGRIK1 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICGRIK1  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDGRIK1
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch GRIK1
DgiDB (Drug Gene Interaction Database)GRIK1
DoCM (Curated mutations)GRIK1 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)GRIK1 (select a term)
intoGenGRIK1
Cancer3DGRIK1(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM138245   
Orphanet
MedgenGRIK1
Genetic Testing Registry GRIK1
NextProtP39086 [Medical]
TSGene2897
GENETestsGRIK1
Huge Navigator GRIK1 [HugePedia]
snp3D : Map Gene to Disease2897
BioCentury BCIQGRIK1
ClinGenGRIK1
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD2897
Chemical/Pharm GKB GenePA28973
Clinical trialGRIK1
Miscellaneous
canSAR (ICR)GRIK1 (select the gene name)
Probes
Litterature
PubMed56 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineGRIK1
EVEXGRIK1
GoPubMedGRIK1
iHOPGRIK1
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Tue Mar 14 12:06:54 CET 2017

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