GRIK2 (glutamate ionotropic receptor kainate type subunit 2)

2018-07-01  

Identity

HGNC
GRIK2
LOCATION
6q16.3
LOCUSID
2898
ALIAS
EAA4,GLR6,GLUK6,GLUR6,GluK2,MRT6
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 2898
MIM: 138244
HGNC: 4580
Ensembl: ENSG00000164418

Variants:

dbSNP: 2898
ClinVar: 2898
TCGA: ENSG00000164418
COSMIC: GRIK2

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000164418ENST00000318991A0A0A0MR30
ENSG00000164418ENST00000358361G3XAD3
ENSG00000164418ENST00000369134F8WEZ8
ENSG00000164418ENST00000369137A0A0A0MRL4
ENSG00000164418ENST00000369138Q13002
ENSG00000164418ENST00000413795Q13002
ENSG00000164418ENST00000421544Q13002
ENSG00000164418ENST00000436862H7C2P5
ENSG00000164418ENST00000455610H7BZX7

Expression (GTEx)

0
10
20
30
40
50
60
70
80
90
100
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Neuroactive ligand-receptor interactionKEGGko04080
Neuroactive ligand-receptor interactionKEGGhsa04080
Glutamatergic synapseKEGGko04724
Glutamatergic synapseKEGGhsa04724
Neuronal SystemREACTOMER-HSA-112316
Transmission across Chemical SynapsesREACTOMER-HSA-112315
Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic CellREACTOMER-HSA-112314
Activation of Kainate Receptors upon glutamate bindingREACTOMER-HSA-451326
Ionotropic activity of Kainate ReceptorsREACTOMER-HSA-451306
Activation of Na-permeable Kainate ReceptorsREACTOMER-HSA-451307
Activation of Ca-permeable Kainate ReceptorREACTOMER-HSA-451308

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
185198262008Molecular genetics of successful smoking cessation: convergent genome-wide association study results.130
119201572002Linkage and association of the glutamate receptor 6 gene with autism.89
248212232015Genome-wide association study in obsessive-compulsive disorder: results from the OCGAS.84
192682762009Genome-wide association study of smoking initiation and current smoking.77
246629272015Astrocytic abnormalities and global DNA methylation patterns in depression and suicide.65
203796142010Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.62
178470032007A defect in the ionotropic glutamate receptor 6 gene (GRIK2) is associated with autosomal recessive mental retardation.53
190860532009Identification of new putative susceptibility genes for several psychiatric disorders by association analysis of regulatory and non-synonymous SNPs of 306 genes involved in neurotransmission and neurodevelopment.34
192601412009Genome-wide association study of biochemical traits in Korcula Island, Croatia.30
150944792004Frequency and transmission of glutamate receptors GRIK2 and GRIK3 polymorphisms in patients with obsessive compulsive disorder.27

Citation

Dessen P

GRIK2 (glutamate ionotropic receptor kainate type subunit 2)

Atlas Genet Cytogenet Oncol Haematol. 2018-07-01

Online version: http://atlasgeneticsoncology.org/gene/57393/grik2