Atlas of Genetics and Cytogenetics in Oncology and Haematology


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GRIK3 (glutamate ionotropic receptor kainate type subunit 3)

Identity

Other aliasEAA5
GLR7
GLUR7
GluK3
GluR7a
HGNC (Hugo) GRIK3
LocusID (NCBI) 2899
Atlas_Id 56991
Location 1p34.3  [Link to chromosome band 1p34]
Location_base_pair Starts at 36795527 and ends at 37034243 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2016)
CDCA8 (1p34.3) / GRIK3 (1p34.3)LRBA (4q31.3) / GRIK3 (1p34.3)MACF1 (1p34.3) / GRIK3 (1p34.3)
RERGL (12p12.3) / GRIK3 (1p34.3)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)GRIK3   4581
Cards
Entrez_Gene (NCBI)GRIK3  2899  glutamate ionotropic receptor kainate type subunit 3
AliasesEAA5; GLR7; GLUR7; GluK3; 
GluR7a
GeneCards (Weizmann)GRIK3
Ensembl hg19 (Hinxton) [Gene_View]
Ensembl hg38 (Hinxton) [Gene_View]  chr1:36795527-37034243 [Contig_View]  GRIK3 [Vega]
TCGA cBioPortalGRIK3
AceView (NCBI)GRIK3
Genatlas (Paris)GRIK3
WikiGenes2899
SOURCE (Princeton)GRIK3
Genetics Home Reference (NIH)GRIK3
Genomic and cartography
GoldenPath hg38 (UCSC)GRIK3  -     chr1:36795527-37034243 -  1p34.3   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)GRIK3  -     1p34.3   [Description]    (hg19-Feb_2009)
EnsemblGRIK3 - 1p34.3 [CytoView hg19]  GRIK3 - 1p34.3 [CytoView hg38]
Mapping of homologs : NCBIGRIK3 [Mapview hg19]  GRIK3 [Mapview hg38]
OMIM138243   
Gene and transcription
Genbank (Entrez)AJ249210 AJ299451 AW898512 BC156721 BG057125
RefSeq transcript (Entrez)NM_000831
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)GRIK3
Cluster EST : UnigeneHs.128848 [ NCBI ]
CGAP (NCI)Hs.128848
Gene ExpressionGRIK3 [ NCBI-GEO ]   GRIK3 [ EBI - ARRAY_EXPRESS ]   GRIK3 [ SEEK ]   GRIK3 [ MEM ]
Gene Expression Viewer (FireBrowse)GRIK3 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)2899
GTEX Portal (Tissue expression)GRIK3
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ13003   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ13003  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ13003
Splice isoforms : SwissVarQ13003
PhosPhoSitePlusQ13003
Domains : Interpro (EBI)ANF_lig-bd_rcpt    Glu/Gly-bd    Iono_rcpt_met    Iontro_rcpt    Peripla_BP_I   
Domain families : Pfam (Sanger)ANF_receptor (PF01094)    Lig_chan (PF00060)    Lig_chan-Glu_bd (PF10613)   
Domain families : Pfam (NCBI)pfam01094    pfam00060    pfam10613   
Domain families : Smart (EMBL)Lig_chan-Glu_bd (SM00918)  PBPe (SM00079)  
Conserved Domain (NCBI)GRIK3
DMDM Disease mutations2899
Blocks (Seattle)GRIK3
SuperfamilyQ13003
Peptide AtlasQ13003
IPIIPI00011397   IPI00382765   IPI00646850   
Protein Interaction databases
DIP (DOE-UCLA)Q13003
IntAct (EBI)Q13003
BioGRIDGRIK3
STRING (EMBL)GRIK3
ZODIACGRIK3
Ontologies - Pathways
QuickGOQ13003
Ontology : AmiGOadenylate cyclase inhibiting G-protein coupled glutamate receptor activity  G-protein coupled receptor binding  ionotropic glutamate receptor activity  ionotropic glutamate receptor activity  extracellular-glutamate-gated ion channel activity  plasma membrane  integral component of plasma membrane  adenylate cyclase-inhibiting G-protein coupled glutamate receptor signaling pathway  glutamate receptor signaling pathway  G-protein coupled glutamate receptor signaling pathway  glutamate receptor activity  ligand-gated ion channel activity  kainate selective glutamate receptor activity  cell junction  axon  dendrite  dendrite cytoplasm  ionotropic glutamate receptor signaling pathway  sodium ion transmembrane transport  regulation of membrane potential  regulation of membrane potential  terminal bouton  perikaryon  postsynaptic membrane  negative regulation of synaptic transmission, glutamatergic  excitatory postsynaptic potential  potassium ion transmembrane transport  
Ontology : EGO-EBIadenylate cyclase inhibiting G-protein coupled glutamate receptor activity  G-protein coupled receptor binding  ionotropic glutamate receptor activity  ionotropic glutamate receptor activity  extracellular-glutamate-gated ion channel activity  plasma membrane  integral component of plasma membrane  adenylate cyclase-inhibiting G-protein coupled glutamate receptor signaling pathway  glutamate receptor signaling pathway  G-protein coupled glutamate receptor signaling pathway  glutamate receptor activity  ligand-gated ion channel activity  kainate selective glutamate receptor activity  cell junction  axon  dendrite  dendrite cytoplasm  ionotropic glutamate receptor signaling pathway  sodium ion transmembrane transport  regulation of membrane potential  regulation of membrane potential  terminal bouton  perikaryon  postsynaptic membrane  negative regulation of synaptic transmission, glutamatergic  excitatory postsynaptic potential  potassium ion transmembrane transport  
Pathways : KEGGNeuroactive ligand-receptor interaction    Glutamatergic synapse   
NDEx NetworkGRIK3
Atlas of Cancer Signalling NetworkGRIK3
Wikipedia pathwaysGRIK3
Orthology - Evolution
OrthoDB2899
Phylogenetic Trees/Animal Genes : TreeFamGRIK3
HOVERGENQ13003
HOGENOMQ13003
Homologs : HomoloGeneGRIK3
Homology/Alignments : Family Browser (UCSC)GRIK3
Gene fusions - Rearrangements
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerGRIK3 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)GRIK3
dbVarGRIK3
ClinVarGRIK3
1000_GenomesGRIK3 
Exome Variant ServerGRIK3
ExAC (Exome Aggregation Consortium)GRIK3 (select the gene name)
Genetic variants : HAPMAP2899
Genomic Variants (DGV)GRIK3 [DGVbeta]
DECIPHERGRIK3 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisGRIK3 
Mutations
ICGC Data PortalGRIK3 
TCGA Data PortalGRIK3 
Broad Tumor PortalGRIK3
OASIS PortalGRIK3 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICGRIK3  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDGRIK3
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch GRIK3
DgiDB (Drug Gene Interaction Database)GRIK3
DoCM (Curated mutations)GRIK3 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)GRIK3 (select a term)
intoGenGRIK3
Cancer3DGRIK3(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM138243   
Orphanet
MedgenGRIK3
Genetic Testing Registry GRIK3
NextProtQ13003 [Medical]
TSGene2899
GENETestsGRIK3
Target ValidationGRIK3
Huge Navigator GRIK3 [HugePedia]
snp3D : Map Gene to Disease2899
BioCentury BCIQGRIK3
ClinGenGRIK3
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD2899
Chemical/Pharm GKB GenePA28975
Clinical trialGRIK3
Miscellaneous
canSAR (ICR)GRIK3 (select the gene name)
Probes
Litterature
PubMed35 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineGRIK3
EVEXGRIK3
GoPubMedGRIK3
iHOP4/A><+Td>GRIK3
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Mon Sep 18 13:54:45 CEST 2017

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