GRIK3 (glutamate ionotropic receptor kainate type subunit 3)

2017-08-01  

Identity

HGNC
GRIK3
LOCATION
1p34.3
LOCUSID
2899
ALIAS
EAA5,GLR7,GLUR7,GluK3,GluR7a
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 2899
MIM: 138243
HGNC: 4581
Ensembl: ENSG00000163873

Variants:

dbSNP: 2899
ClinVar: 2899
TCGA: ENSG00000163873
COSMIC: GRIK3

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000163873ENST00000373091Q13003
ENSG00000163873ENST00000373093Q13003

Expression (GTEx)

0
5
10
15
20
25
30
35
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Neuroactive ligand-receptor interactionKEGGko04080
Neuroactive ligand-receptor interactionKEGGhsa04080
Glutamatergic synapseKEGGko04724
Glutamatergic synapseKEGGhsa04724
Neuronal SystemREACTOMER-HSA-112316
Transmission across Chemical SynapsesREACTOMER-HSA-112315
Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic CellREACTOMER-HSA-112314
Activation of Kainate Receptors upon glutamate bindingREACTOMER-HSA-451326
Ionotropic activity of Kainate ReceptorsREACTOMER-HSA-451306
Activation of Ca-permeable Kainate ReceptorREACTOMER-HSA-451308
Presynaptic function of Kainate receptorsREACTOMER-HSA-500657

PharmGKB

Entity IDNameTypeEvidenceAssociationPKPDPMIDs
PA443937Drug ToxicityDiseaseVariantAnnotationassociatedPD27272046
PA447215Psychotic DisordersDiseaseClinicalAnnotation, VariantAnnotationassociatedPD27272046
PA452233antipsychoticsChemicalClinicalAnnotation, VariantAnnotationassociatedPD27272046

References

Pubmed IDYearTitleCitations
203796142010Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.62
190860532009Identification of new putative susceptibility genes for several psychiatric disorders by association analysis of regulatory and non-synonymous SNPs of 306 genes involved in neurotransmission and neurodevelopment.34
150944792004Frequency and transmission of glutamate receptors GRIK2 and GRIK3 polymorphisms in patients with obsessive compulsive disorder.27
150944792004Frequency and transmission of glutamate receptors GRIK2 and GRIK3 polymorphisms in patients with obsessive compulsive disorder.27
193206262009Association of markers in the 3' region of the GluR5 kainate receptor subunit gene to alcohol dependence.27
169580292007Association of the human kainate receptor GluR7 gene (GRIK3) with recurrent major depressive disorder.23
169580292007Association of the human kainate receptor GluR7 gene (GRIK3) with recurrent major depressive disorder.23
200526092010Association of existing and new candidate genes for anxiety, depression and personality traits in older people.15
119869862002Association between the ionotropic glutamate receptor kainate 3 (GRIK3) ser310ala polymorphism and schizophrenia.13
119869862002Association between the ionotropic glutamate receptor kainate 3 (GRIK3) ser310ala polymorphism and schizophrenia.13

Citation

Dessen P

GRIK3 (glutamate ionotropic receptor kainate type subunit 3)

Atlas Genet Cytogenet Oncol Haematol. 2017-08-01

Online version: http://atlasgeneticsoncology.org/gene/56991/grik3