Atlas of Genetics and Cytogenetics in Oncology and Haematology


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GRIK4 (glutamate ionotropic receptor kainate type subunit 4)

Identity

Alias_namesGRIK
glutamate receptor, ionotropic, kainate 4
Alias_symbol (synonym)GluK4
KA1
Other aliasEAA1
HGNC (Hugo) GRIK4
LocusID (NCBI) 2900
Atlas_Id 64044
Location 11q23.3  [Link to chromosome band 11q23]
Location_base_pair Starts at 120564436 and ends at 120988804 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2016)
GRIK4 (11q23.3) / TMPRSS4 (11q23.3)MLIP (6p12.1) / GRIK4 (11q23.3)TENM4 (11q14.1) / GRIK4 (11q23.3)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)GRIK4   4582
LRG (Locus Reference Genomic)LRG_1012
Cards
Entrez_Gene (NCBI)GRIK4  2900  glutamate ionotropic receptor kainate type subunit 4
AliasesEAA1; GRIK; GluK4; KA1
GeneCards (Weizmann)GRIK4
Ensembl hg19 (Hinxton)ENSG00000149403 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000149403 [Gene_View]  chr11:120564436-120988804 [Contig_View]  GRIK4 [Vega]
ICGC DataPortalENSG00000149403
TCGA cBioPortalGRIK4
AceView (NCBI)GRIK4
Genatlas (Paris)GRIK4
WikiGenes2900
SOURCE (Princeton)GRIK4
Genetics Home Reference (NIH)GRIK4
Genomic and cartography
GoldenPath hg38 (UCSC)GRIK4  -     chr11:120564436-120988804 +  11q23.3   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)GRIK4  -     11q23.3   [Description]    (hg19-Feb_2009)
EnsemblGRIK4 - 11q23.3 [CytoView hg19]  GRIK4 - 11q23.3 [CytoView hg38]
Mapping of homologs : NCBIGRIK4 [Mapview hg19]  GRIK4 [Mapview hg38]
OMIM600282   
Gene and transcription
Genbank (Entrez)AB231709 AK292726 AK314284 AW016926 BC146652
RefSeq transcript (Entrez)NM_001282470 NM_001282473 NM_014619
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)GRIK4
Cluster EST : UnigeneHs.568901 [ NCBI ]
CGAP (NCI)Hs.568901
Alternative Splicing GalleryENSG00000149403
Gene ExpressionGRIK4 [ NCBI-GEO ]   GRIK4 [ EBI - ARRAY_EXPRESS ]   GRIK4 [ SEEK ]   GRIK4 [ MEM ]
Gene Expression Viewer (FireBrowse)GRIK4 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)2900
GTEX Portal (Tissue expression)GRIK4
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ16099   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ16099  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ16099
Splice isoforms : SwissVarQ16099
PhosPhoSitePlusQ16099
Domains : Interpro (EBI)ANF_lig-bd_rcpt    Glu/Gly-bd    Iono_rcpt_met    Iontro_rcpt    Peripla_BP_I   
Domain families : Pfam (Sanger)ANF_receptor (PF01094)    Lig_chan (PF00060)    Lig_chan-Glu_bd (PF10613)   
Domain families : Pfam (NCBI)pfam01094    pfam00060    pfam10613   
Domain families : Smart (EMBL)Lig_chan-Glu_bd (SM00918)  PBPe (SM00079)  
Conserved Domain (NCBI)GRIK4
DMDM Disease mutations2900
Blocks (Seattle)GRIK4
SuperfamilyQ16099
Human Protein AtlasENSG00000149403
Peptide AtlasQ16099
HPRD02613
IPIIPI00292269   IPI00847212   
Protein Interaction databases
DIP (DOE-UCLA)Q16099
IntAct (EBI)Q16099
FunCoupENSG00000149403
BioGRIDGRIK4
STRING (EMBL)GRIK4
ZODIACGRIK4
Ontologies - Pathways
QuickGOQ16099
Ontology : AmiGOextracellular-glutamate-gated ion channel activity  plasma membrane  integral component of plasma membrane  transport  glutamate receptor signaling pathway  chemical synaptic transmission  ligand-gated ion channel activity  kainate selective glutamate receptor activity  cell junction  kainate selective glutamate receptor complex  ionotropic glutamate receptor signaling pathway  sodium ion transmembrane transport  presynaptic membrane  postsynaptic membrane  excitatory postsynaptic potential  potassium ion transmembrane transport  
Ontology : EGO-EBIextracellular-glutamate-gated ion channel activity  plasma membrane  integral component of plasma membrane  transport  glutamate receptor signaling pathway  chemical synaptic transmission  ligand-gated ion channel activity  kainate selective glutamate receptor activity  cell junction  kainate selective glutamate receptor complex  ionotropic glutamate receptor signaling pathway  sodium ion transmembrane transport  presynaptic membrane  postsynaptic membrane  excitatory postsynaptic potential  potassium ion transmembrane transport  
Pathways : KEGGNeuroactive ligand-receptor interaction    Glutamatergic synapse   
NDEx NetworkGRIK4
Atlas of Cancer Signalling NetworkGRIK4
Wikipedia pathwaysGRIK4
Orthology - Evolution
OrthoDB2900
GeneTree (enSembl)ENSG00000149403
Phylogenetic Trees/Animal Genes : TreeFamGRIK4
HOVERGENQ16099
HOGENOMQ16099
Homologs : HomoloGeneGRIK4
Homology/Alignments : Family Browser (UCSC)GRIK4
Gene fusions - Rearrangements
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerGRIK4 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)GRIK4
dbVarGRIK4
ClinVarGRIK4
1000_GenomesGRIK4 
Exome Variant ServerGRIK4
ExAC (Exome Aggregation Consortium)GRIK4 (select the gene name)
Genetic variants : HAPMAP2900
Genomic Variants (DGV)GRIK4 [DGVbeta]
DECIPHERGRIK4 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisGRIK4 
Mutations
ICGC Data PortalGRIK4 
TCGA Data PortalGRIK4 
Broad Tumor PortalGRIK4
OASIS PortalGRIK4 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICGRIK4  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDGRIK4
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch GRIK4
DgiDB (Drug Gene Interaction Database)GRIK4
DoCM (Curated mutations)GRIK4 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)GRIK4 (select a term)
intoGenGRIK4
Cancer3DGRIK4(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM600282   
Orphanet
MedgenGRIK4
Genetic Testing Registry GRIK4
NextProtQ16099 [Medical]
TSGene2900
GENETestsGRIK4
Target ValidationGRIK4
Huge Navigator GRIK4 [HugePedia]
snp3D : Map Gene to Disease2900
BioCentury BCIQGRIK4
ClinGenGRIK4
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD2900
Chemical/Pharm GKB GenePA28976
Clinical trialGRIK4
Miscellaneous
canSAR (ICR)GRIK4 (select the gene name)
Probes
Litterature
PubMed29 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineGRIK4
EVEXGRIK4
GoPubMedGRIK4
iHOPGRIK4
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Wed Jun 7 15:51:28 CEST 2017

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