Atlas of Genetics and Cytogenetics in Oncology and Haematology


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GRIK5 (glutamate ionotropic receptor kainate type subunit 5)

Identity

Alias_namesGRIK2
glutamate receptor
Alias_symbol (synonym)GluK5
KA2
Other aliasEAA2
HGNC (Hugo) GRIK5
LocusID (NCBI) 2901
Atlas_Id 56078
Location 19q13.2  [Link to chromosome band 19q13]
Location_base_pair Starts at 42001789 and ends at 42065815 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2016)
TSC22D3 (Xq22.3) / GRIK5 (19q13.2)ZNF577 (19q13.41) / GRIK5 (19q13.2)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)GRIK5   4583
Cards
Entrez_Gene (NCBI)GRIK5  2901  glutamate ionotropic receptor kainate type subunit 5
AliasesEAA2; GRIK2; GluK5; KA2
GeneCards (Weizmann)GRIK5
Ensembl hg19 (Hinxton)ENSG00000105737 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000105737 [Gene_View]  chr19:42001789-42065815 [Contig_View]  GRIK5 [Vega]
ICGC DataPortalENSG00000105737
TCGA cBioPortalGRIK5
AceView (NCBI)GRIK5
Genatlas (Paris)GRIK5
WikiGenes2901
SOURCE (Princeton)GRIK5
Genetics Home Reference (NIH)GRIK5
Genomic and cartography
GoldenPath hg38 (UCSC)GRIK5  -     chr19:42001789-42065815 -  19q13.2   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)GRIK5  -     19q13.2   [Description]    (hg19-Feb_2009)
EnsemblGRIK5 - 19q13.2 [CytoView hg19]  GRIK5 - 19q13.2 [CytoView hg38]
Mapping of homologs : NCBIGRIK5 [Mapview hg19]  GRIK5 [Mapview hg38]
OMIM600283   
Gene and transcription
Genbank (Entrez)AJ249209 BC037358 BC052975 BC131717 BC168375
RefSeq transcript (Entrez)NM_001301030 NM_002088
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)GRIK5
Cluster EST : UnigeneHs.367799 [ NCBI ]
CGAP (NCI)Hs.367799
Alternative Splicing GalleryENSG00000105737
Gene ExpressionGRIK5 [ NCBI-GEO ]   GRIK5 [ EBI - ARRAY_EXPRESS ]   GRIK5 [ SEEK ]   GRIK5 [ MEM ]
Gene Expression Viewer (FireBrowse)GRIK5 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)2901
GTEX Portal (Tissue expression)GRIK5
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ16478   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ16478  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ16478
Splice isoforms : SwissVarQ16478
PhosPhoSitePlusQ16478
Domains : Interpro (EBI)ANF_lig-bd_rcpt    Glu/Gly-bd    Iono_rcpt_met    Iontro_rcpt    Peripla_BP_I   
Domain families : Pfam (Sanger)ANF_receptor (PF01094)    Lig_chan (PF00060)    Lig_chan-Glu_bd (PF10613)   
Domain families : Pfam (NCBI)pfam01094    pfam00060    pfam10613   
Domain families : Smart (EMBL)Lig_chan-Glu_bd (SM00918)  PBPe (SM00079)  
Conserved Domain (NCBI)GRIK5
DMDM Disease mutations2901
Blocks (Seattle)GRIK5
SuperfamilyQ16478
Human Protein AtlasENSG00000105737
Peptide AtlasQ16478
HPRD02614
IPIIPI00293288   IPI00103335   
Protein Interaction databases
DIP (DOE-UCLA)Q16478
IntAct (EBI)Q16478
FunCoupENSG00000105737
BioGRIDGRIK5
STRING (EMBL)GRIK5
ZODIACGRIK5
Ontologies - Pathways
QuickGOQ16478
Ontology : AmiGOextracellular-glutamate-gated ion channel activity  endoplasmic reticulum  plasma membrane  protein retention in ER lumen  postsynaptic density  ligand-gated ion channel activity  kainate selective glutamate receptor activity  SH3 domain binding  cell junction  PDZ domain binding  dendrite  regulation of synaptic vesicle fusion to presynaptic active zone membrane  kainate selective glutamate receptor complex  ionotropic glutamate receptor signaling pathway  synaptic transmission, glutamatergic  sodium ion transmembrane transport  presynaptic membrane  identical protein binding  receptor clustering  terminal bouton  perikaryon  positive regulation of neuron apoptotic process  postsynaptic membrane  establishment of localization in cell  excitatory postsynaptic potential  cellular response to glucose stimulus  potassium ion transmembrane transport  
Ontology : EGO-EBIextracellular-glutamate-gated ion channel activity  endoplasmic reticulum  plasma membrane  protein retention in ER lumen  postsynaptic density  ligand-gated ion channel activity  kainate selective glutamate receptor activity  SH3 domain binding  cell junction  PDZ domain binding  dendrite  regulation of synaptic vesicle fusion to presynaptic active zone membrane  kainate selective glutamate receptor complex  ionotropic glutamate receptor signaling pathway  synaptic transmission, glutamatergic  sodium ion transmembrane transport  presynaptic membrane  identical protein binding  receptor clustering  terminal bouton  perikaryon  positive regulation of neuron apoptotic process  postsynaptic membrane  establishment of localization in cell  excitatory postsynaptic potential  cellular response to glucose stimulus  potassium ion transmembrane transport  
Pathways : KEGGNeuroactive ligand-receptor interaction    Glutamatergic synapse   
NDEx NetworkGRIK5
Atlas of Cancer Signalling NetworkGRIK5
Wikipedia pathwaysGRIK5
Orthology - Evolution
OrthoDB2901
GeneTree (enSembl)ENSG00000105737
Phylogenetic Trees/Animal Genes : TreeFamGRIK5
HOVERGENQ16478
HOGENOMQ16478
Homologs : HomoloGeneGRIK5
Homology/Alignments : Family Browser (UCSC)GRIK5
Gene fusions - Rearrangements
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerGRIK5 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)GRIK5
dbVarGRIK5
ClinVarGRIK5
1000_GenomesGRIK5 
Exome Variant ServerGRIK5
ExAC (Exome Aggregation Consortium)GRIK5 (select the gene name)
Genetic variants : HAPMAP2901
Genomic Variants (DGV)GRIK5 [DGVbeta]
DECIPHERGRIK5 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisGRIK5 
Mutations
ICGC Data PortalGRIK5 
TCGA Data PortalGRIK5 
Broad Tumor PortalGRIK5
OASIS PortalGRIK5 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICGRIK5  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDGRIK5
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch GRIK5
DgiDB (Drug Gene Interaction Database)GRIK5
DoCM (Curated mutations)GRIK5 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)GRIK5 (select a term)
intoGenGRIK5
Cancer3DGRIK5(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM600283   
Orphanet
MedgenGRIK5
Genetic Testing Registry GRIK5
NextProtQ16478 [Medical]
TSGene2901
GENETestsGRIK5
Target ValidationGRIK5
Huge Navigator GRIK5 [HugePedia]
snp3D : Map Gene to Disease2901
BioCentury BCIQGRIK5
ClinGenGRIK5
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD2901
Chemical/Pharm GKB GenePA28977
Clinical trialGRIK5
Miscellaneous
canSAR (ICR)GRIK5 (select the gene name)
Probes
Litterature
PubMed20 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineGRIK5
EVEXGRIK5
GoPubMedGRIK5
iHOPGRIK5
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Mon Sep 25 19:10:36 CEST 2017

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